The continuing challenge of treatment for non-Hodgkin's lymphoma in children

British Journal of Haematology

Volumn 107, Issue 2, 1999, Pages 220-234

  Pinkerton, C R ^a  

^a NONE

Author keywords

Children; Non Hodgkin's lymphoma therapy

Indexed keywords

ACICLOVIR; ALPHA INTERFERON; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; ASPARAGINASE; BLEOMYCIN; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; DAUNORUBICIN; DOXORUBICIN; ETOPOSIDE; GALLIUM; GANCICLOVIR; LOMUSTINE; METHOTREXATE; METHYLPREDNISOLONE; MONOCLONAL ANTIBODY; PREDNISOLONE; PREDNISONE; PROCARBAZINE; VINBLASTINE; VINCRISTINE;

B CELL LYMPHOMA; CANCER CLASSIFICATION; CANCER COMBINATION CHEMOTHERAPY; CANCER SURVIVAL; CHILD; CHILDHOOD CANCER; DRUG INDUCED DISEASE; FOLLICULAR LYMPHOMA; HUMAN; INTRATHECAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LARGE CELL LYMPHOMA; LYMPHOPROLIFERATIVE DISEASE; NEUTROPENIA; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; REVIEW; TREATMENT OUTCOME; VIRUS INFECTION;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHILD; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOCOMPROMISED HOST; LYMPHOMA, NON-HODGKIN;

EID: 0032708125     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1999.01524.x     Document Type: Review

References (109)

1. Anderson, J.R., Jenkin, R.D.T., Wilson, J.F., Kjeldsberg, C.R., Sposto, R., Chilcote, R.R., Coccia, P.F., Exelby, P.R., Siegel, S. & Meadows, A.T. (1993) Long-term follow-up of patients treated with COMP or LSA2L2 therapy for childhood non-Hodgkin's lymphoma: a report of CCG-55 1 from the Children's Cancer Group. Journal of Clinical Oncology, 11, 1124-1132.
2. Anderson, J.R., Wilson, J.S., Jenkins, D.T., Meadows, A.T., Kersey, J., Chilcote, R.R., Coccia, P., Exelby, P., Kushner, J., Siegel, S. & Hammond, D. (1983) Childhood non-Hodgkin's lymphoma: the results of a randomized therapeutic trial comparing a four-drug regimen (COMP) with a ten-drug regimen (LSA2-L2). New England Journal of Medicine. 308, 559-565.
3. Armitage, J.O. & Weisenburger, D.D. (1998) New approach to classifying non-Hodgkin's lymphomas: clinical features of the major histological subtypes. Journal of Clinical Oncology, 16, 2780-2795.
4. Atra, A., Gerrard, M., Hobson, R., Imeson, J.D., Ashley, S. & Pinkerton, C.R. (1998a) Improved cure rate in children with B cell acute lymphoblastic leukaemia (B ALL) and stage IV B cell non-Hodgkin's lymphoma (B NHL): results of the UKCCSG 9003 protocol. British Journal of Cancer, 77, 2281-2285.
5. Atra, A., Meller, S.T., Stevens, R.F., Hobson, R., Grundy, R., Carter, R.L. & Pinkerton, C.R. (1998b) Conservative management of follicular non-Hodgkin's lymphoma in childhood. British Journal of Haematology. 103, 220-223.
6. Benkerrou, M., Jais, J.-P., Leblond, V., Durandy, A., Sutton, L., Bordigoni, P., Garnier, J.L., Le Bidois, J., LeDeist, F., Blanche, S. & Fischer, A. (1998) Anti B cell monoclonal antibody treatment of severe post transplant B lymphoproliferative disorder: prognostic factors and long term outcome. Blood, 9, 3137-3147.
7. Bowman, W.P., Shuster, J.J., Cook, B., Behm, F., Pullen, J., Link, M., Head, D., Carroll, A., Berard, C. & Murphy, S. (1996) Improved survival for children with B cell acute lymphoblastic leukemia and stage IV non cleaved lymphomas: a Pediatric Oncology Group study. Journal of Clinical Oncology. 14, 1252-1261.
8. Brada, M., Hjiyannakis, D., Hines, F., Traish, D. & Ashley, S. (1998) Short intensive primary chemotherapy and radiotherapy in sporadic primary CNS lymphoma. International Journal of Radiation Oncology. Biology and Physics, 40, 1157-1162.
9. Brecher, M.L., Schwenn, M.R., Coppes, M.J., Bowman, W.P., Link, M.P., Berard, C.W., Shuster, J.J. & Murphy, S.B. (1997) Fractionated cyclophosphamide and back to back high dose methotrexate and cytosine arabinoside improves the outcome in patients with stage III high grade small non cleaved cell lymphomas: a randomised trial of the Pediatric Oncology Group. Medical and Pediatric Oncology, 29, 526-533.
10. Brugieres, L., Caillaud, J.M., Patte, C., Rodary, C., Bernard, A., Kalifa, C., Hartmann, O. & Lemerle, J. (1989) Malignant histiocytosis: therapeutic results in 27 children treated with a single polychemotherapy regimen. Medical and Pediatric Oncology, 17, 193-196.
11. + anaplastic large cell lymphoma in children: analysis of 83 patients enrolled in two consecutive studies of the French Society of Pediatric Oncology. Blood, 92, 3591-3598.
12. Bunin, N.J., Hvizdala, E., Link, M., Callihao, T.R., Hustu, H.O., Moody, W., Warnke, R.A., Berard, C.W. & Murphy, S.B. (1986) Mediastinal non lymphoblastic lymphomas in children: a clinico-pathological study. Journal of Clinical Oncology, 4, 154-159.
13. Bureo, E., Ortega, J.J., Munoz, A., Cubells, J., Madero, L., Verdaguer, A., Baro, J., Olive, T., Maldonado, M.S. & Pardo, J. (1995) Bone marrow transplantation in 46 pediatric patients with non-Hodgkin's lymphoma. Spanish Working Party for Bone Marrow Transplantation in Children. Bone Marrow Transplantation, 15, 353-359.
14. Cairo, M.S., Krailo, M., Hutchison, R., Harris, R., Meadows, A. & Bleyer, W.A. (1994) Results of a phase II trial of 'French' (F) (LMB-86) or 'orange' (O) (CCG-hybrid) in children with advanced non-lymphoblastic non-Hodgkin's lymphoma: an improvement in survival. (Abstract). Proceedings of the American Society of Clinical Oncology, 13, 392.
15. Chessells, J.M. (1998) Relapsed lymphoblastic leukaemia in children: a continuing challenge. British Journal of Haematology, 102, 423-438.
16. Coppes, M.J., Patte, C., Couanet, D., Caillaud, J.M., Salloum, E., Brugieres, L., Hartmann, O., Kalifa, C., Bernard, A. & Lemerle, J. (1991) Childhood malignant lymphoma of bone. Medical and Pediatric Oncology, 19, 22-27.
17. Dahl, G.V., Rivera, G., Pui, C., Mirro, J.M., Ochs, J.O., Kalwinski, D.K., Abromowitch, M., Look, T. & Murphy, S.B. (1985) A novel treatment of childhood lymphoblastic non-Hodgkin's lymphoma: early and intermittent use of teniposide plus cytarabine. Blood, 322, 1169-1174.
18. Davis, C.L., Wood, B.L., Sabath, D.E., Stehman-Breen, C. & Broudy, V.C. (1998) Interferon alpha treatment of post transplant lymphoproliferative disorder in recipients of solid organ transplants. Transplantation, 66, 1770-1779.
19. DeAngelis, L.M., Yahalom, J., Thaler, H.T. & Kher, U. (1992) Combined modality therapy for primary CNS lymphoma. Journal of Clinical Oncology, 10, 635-643.
20. DeMario, M.D. & Liebowitz, D.N. (1998) Lymphomas in the immunocompromised patient. Seminars in Oncology, 4, 492-502.
21. Dobkin, S.F., Brem, A.S. & Caldamone, A.A. (1991) Primary renal lymphoma. Journal of Urology, 146, 1588-1590.
22. Downing, J., Shurtleff, S., Zielenska, M., Curcio-Brint, A.M., Behm, F.G., Head, D.R., Sandlund, J.T., Weisenberger, D., Kossakovska, A.E., Thorner, P., Lorenzana, A., Ladanyi, M. & Morris, S. (1996) Molecular detection of the t(2;5) (p23;q35) translocation of non-Hodgkin's lymphoma by reverse transcriptase-polymerase chain reaction. Blood, 85, 3416-3422.
23. Eden, O., Hann, I., Imeson, J., Cotterill, S., Gerrard, M. & Pinkerton, C.R. (1992) Treatment of advanced-stage T-cell lymphoblastic lymphoma: results of the United Kingdom Children's Cancer Study Group (UKCCSG) protocol 8503. British Journal of Haematology, 82, 310-316.
24. Eden, O.B., Hann, I., Imeson, J. & Pinkerton, C.R. (1996) Treatment of T cell lymphoma without cranial irradiation, UKCCSG. Proceedings of the Sixth International Conference on Malignant Lymphoma. June 1996. Lugano, Switzerland, abstract 99.
25. Egeler, R.M., Schmitz, L., Sonneveld, P., Mannival, C. & Nesbit, M.E. (1995) Malignant histiocytosis: a reassessment of cases formally classified as histiocytic malignancies and review of the literature. Medical and Pediatric Oncology, 25, 1-7.
26. Evans, J., Gibb, D.M., Holland, F.J., Tookey, P.A., Pritchard, J. & Ades, A.E. (1997) Malignancies in UK children with HIV infection acquired from mother to child transmission. Archives of Diseases in Childhood, 76, 330-333.
27. Ferreri, A.J., Reni, M., Ceresoli, G.L. & Villa, E. (1998) Therapeutic management with adriamycin containing chemotherapy and radiotherapy of monostotic and polyostotic primary non-Hodgkin's lymphoma of bone in adults. Cancer Investigations, 16, 554-561.
28. Ferster, A., Brock, P., Rohrlich, P., Mazingue, F., Plantaz, D., Plouvier, E., Pacquement, H., Rialland, X., Chantraine, J.M., Guilhot, F. & Otten, J. (1997) Cutaneous involvement in children with acute lymphoblastic leukemia or lymphoblastic lymphoma. The Childrens Cooperative Group of the EORTC. Pediatrics, 100, 60-64.
29. Finlay, J.L., Anderson, J.R., Cecalupo, A.J., Hutchinson, RJ., Kadin, M.E., Kjeldsberg, C.R., Provisor, A.J., Woods, W.G. & Meadows, A.T. (1994) Disseminated nonlymphoblastic lymphoma of childhood: a Children's Cancer Group study, CCG-552. Medical and Pediatric Oncology, 23, 453-463.
30. Finlay, J.L., Trigg, M.E., Link, M.P. & Frierdich, S. (1989) Poor risk non lymphoblastic lymphoma of childhood: results of an intensive pilot study. Medical and Pediatric Oncology, 17, 29-38.
31. Fernandez-Acenero, M.J., Galindo, M., Bengoechea, O., Reina, J.J. & Carapeto, R. (1998) Primary malignant lymphoma of the kidney: case report and literature review. General Diagnostic Pathology, 143, 317-320.
32. Forman-Forsyth, P.A. & DeAngelis, L.M. (1996) Biology and management of AID associated prmary CNS lymphomas. Haematology Clinics of North America, 10, 1125-1134.
33. Frizzera, G. & Murphy, S.B. (1979) Follicular (nodular) lymphoma in childhood: a rare clinicopathological entity, report of eight cases from four cancer centres. Cancer, 44, 2218-2235.
34. Garett, T.J., Chadburn, A., Barr, M.L., Drusin, R.E., Chen, J.M., Schulmann, L.L., Smith, C.R., Reison, D.S., Rose, E.A., Michler, R.E. & Knowles, D.M. (1993) Post transplant lymphoproliferative disorder treated with cyclophosphamide, doxorubicin, vincristine, prednisone chemotherapy. Cancer, 72, 2782-2785.
35. Gerrard, M., Pinkerton, C.R. & Hann, I. (1990) Excellent outcome for children with localised non-Hodgkin's lymphoma treated with short duration chemotherapy: where now with therapy? Medical and Pediatric Oncology, 18, 397.
36. Gasparini, M., Rottoli, L., Massimino, M., Gianni, M.C., Ballerini, E., Ravagnani, F., Pupa, S. & Fossati-Bellani, F. (1993) Curability of advanced Burkitt's lymphoma in children by intensive short-term chemotherapy. European Journal of Cancer, 29A, 692-698.
37. Gentet, J.C., Patte, C., Quintana, E., Bergeron, C., Rubie, H., Pein, F., Demaille, M.C., Philip, T. & Raybaud, C. (1990) Phase II study of cytarabine and etoposide in children with refractory or relapsed non-Hodgkin's lymphoma: a study of the SFOP. Journal of Clinical Oncology, 8, 661-665.
38. Gordon, B.G., Phyllis, I., Weisenberger, D.D., Vose, J.M., Sanger, W.G., Strandjord, S.E., Anderson, J.A., Verdirami, J.D., Bierman, P.J., Armitage, J.A. & Coccia, P.F. (1992) Bone marrow transplantation for peripheral T cell lymphoma in children and adolescents. Blood, 80, 2938-2942.
39. Haddy, T.B., Adde, M. & Magrath, I.T. (1991) CNS involvement in small noncleaved-cell lymphomas: is CNS disease per se a poor prognostic sign? Journal of Clinical Oncology, 9, 1973-1982.
40. Haddy, T.B., Keenan, A.M., Jaffe, E.S. & Magrath, I.T. (1988) Bone involvement in young patients with non Hodgkins lymphoma: efficacy of chemotherapy without local radiotherapy. Blood, 72, 1141-1147.
41. Hann, I.M., Eden, O.B., Barnes, J. & Pinkerton, C.R. (1988) MACHO chemotherapy for stage IV B cell lymphoma and a cell acute lymphoblastic leukaemia of childhood. British Journal of Haematology, 76, 359-364.
42. Harris, N.L., Jaffe, E.S., Stein, H., Banks, P.M., Cahn, J.K., Cleary, M.L., Delsol, G., De Wolf-Peeters, C., Falini, B. & Gatter, K.C. (1994) A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood, 84, 1361-1392.
43. Heslop, H.E., Ng, C.Y., Li, C., Smith, C.A., Loftin, S.K., Krance, R.A., Brenner, M.K. & Rooney, C.M. (1996) Long term restoration of immunity against EB virus infection by adoptive transfer of gene modified virus specific T lymphocytes. Nature Medicine, 2, 551-555.
44. Hutchinson, R.E., Berard, C.W., Shuster, J.J., Link, M.P., Pick, T.E. & Murphy, S.B. (1995) B cell lineage confers a favorable outcome among children and adolescents with large cell lymphoma: a Pediatric Oncology Group study. Journal of Clinical Oncology, 13, 2023-2032.
45. Hvizdala, E.V., Berard, C., Callihan, T., Falletta, J., Sabio, H., Shuster, J.J., Sullivan, M. & Wharam, M.D. (1988) Lymphoblastic lymphoma in children: a randomized trial comparing LSA2-L2 with A-COP+ therapeutic regimen. A Pediatric Oncology Group study. Journal of Clinical Oncology, 6, 26-33.
46. Jenkin, R.D.T., Anderson, J., Chilcote, R.R., Coccia, P.F., Exelby, P.R., Kersey, J.H., Kushner, J.H., Meadows, A.T., Siegel, S.F., Sposto, R., Wilson, J.F. & Hammond, G.D. (1984) The treatment of localised non-Hodgkin lymphomas in children: a report from the Children's Cancer Study Group. Journal of Clinical Oncology, 2, 88-97.
47. Kadin, M.E. (1991) Ki-1-positive anaplastic large-cell lymphoma: a clinicopathologic entity? Journal of Clinical Oncology, 9, 533-536.
48. Kellie, S.J., Pui, C.H. & Murphy, S.B. (1989) Childhood non-Hodgkin's lymphoma involving the testis: clinical features and treatment outcome. Journal of Clinical Oncology, 7, 1066-1070.
49. Lazzarino, M., Orlandi, E., Paullli, M., Strater, J., Klersy, C., Gianelli, U. & Gargantini, N. (1997) Treatment outcome and prognostic factors for primary medistinal (thymic) B cell lymphoma: a multicentre study of 106 patients. Journal of Clinical Oncology, 15, 1646-1653.
50. Leach, M., Parsons, R.M., Reilly, J.T. & Winfield, D.A. (1998) Efficacy of urate oxidase (uricozyme) in tumour lysis induced urate nephropathy. Clinical and Laboratory Haematology, 20, 169-172.
51. Levine, A.M., Sullivan-Haley, J., Pike, M.C., Bernstein-Singer, M., Willson, E., Brynes, R., Parker, J., Rasheed, S. & Gill, P.S. (1991) Human immunodeficiency virus related lymphoma: prognostic factors predictive of survival. Cancer, 68, 2466-2472.
52. Link, M.P., Donaldson, S.S., Berard, C.W., Shuster, J.J. & Murphy, S.B. (1990) Results of treatment of childhood localized non-Hodgkin's lymphoma with combination chemotherapy with or without radiotherapy. New England Journal of Medicine, 322, 1169-1174.
53. Link, M.P., Shuster, J., Donaldson, S.S., Berard, C.W. & Murphy, S.B. (1993) Treatment of children with localized non-Hodgkin's lymphoma (NHL) with nine weeks of chemotherapy without radiotherapy. (Abstract). Medical Pediatric Oncology, 21, 532.
54. Link, M.P., Shuster, J.J., Donaldson, S.S., Berard, C.W. & Murphy, S.B. (1997) Treatment of children and young adults with early stage non-Hodgkin's lymphoma. New England Journal of Medicine, 337, 1259-1266.
55. Loefller, J.S., Tarbell N.J., Kosakewich, H., Casssady, J.R. & Weistein, H.J. (1986) Primary lymphoma of bone in children: analysis of treatment results with adriamycin, prednisolone, oncovin (APO) and local radiation therapy. Journal of Clinical Oncology, 4, 496-501.
56. +) with the t(2;5) and other 2p23 abnormalities. Blood, 86, 531a.
57. Magrath, I. (1997) Limiting therapy for limited stage childhood non-Hodgkin's lymphoma. New England Journal of Medicine, 337, 1304-1306.
58. Magrath, I.T., James, C., Edwards, B.K., Spiegel, R., Jaffe, E.S., Berard, C.W., Milauskas, J., Morris, K. & Barnwell, R. (1984) An effective therapy for both undifferentiated (including Burkitt's) lymphomas and lymphoblastic lymphomas in children and young adults. Blood, 63, 1102-1111.
59. Martelli, M.P., Martelli, M., Pescarmona, E., De Sanctis, V., Donato, V., Palombi, F., Todisco, E., Rendina, E.A., Pau, F.M. & Mandelli, F. (1998) MACOPB and involved field radiation therapy is an effective therapy for primary mediastinal large B cell lymphoma with sclerosis. Annals of Oncology, 9, 1027-1029.
60. Massimino, M., Gasparini, M. & Giardini, R. (1995) CD30 anaplastic large cell lymphoma in children. Annals of Oncology, 6, 915-920.
61. McLaughlin, A., Magee, M., Greenough, R., Allman, K.C., Southee, A.F., Meikle, S.R., Hutton, B.F., Joshua, D.E., Bautovich, G.J. & Morris, J.G. (1990) Current role of gallium scanning in the management of lymphoma. European Journal of Nuclear Medicine, 16, 755-771.
62. Meadows, A.T., Sposto, R., Jenkin, R.T., Kersey, J.H., Chilcote, R.R., Siegel, S.E., Coccia, P.F., Rosenstock, J., Pringle, K.C., Stolar, C.J., Kadin, M.E. & Hammond, G.D. (1989) Similar efficacy of 6 and 18 months of therapy with four drugs (COMP) for localized non-Hodgkin's lymphoma of children: a report from the Children's Cancer Study Group. Journal of Clinical Oncology, 7, 92-99.
63. Millot, F., Robert, A., Bertrand, Y., Mechinaud, F., Laureys, G., Ferster, A., Brock, P., Rohrlich, P., Mazingue, F., Plantaz, D., Plouvier, E., Pacqement, H., Behar, C., Rialland, X., Chantraine, J.M., Guilhot, F. & Otten, J. (1997) Cutaneous involvement in children with acute lymphoblastic leukemia or lymphoblastic lymphoma. The Childrens Leukemia Cooperative Group of the European Organisation of Resarch and Treatment of Cancer (EORTC). Pediatrics, 100, 60-64.
64. Moog, F., Bangerter, M., Kotzerke, J., Guhlmann, A., Fricjhofen, N. & Reske, S.N. (1998) 18F fluorodeoxyglucose positron emission tomography as a new approach to detect lymphomatous bone marrow. Journal of Clinical Oncology, 16, 603-609.
65. Mott, M.G., Chessells, J.M., Willoughby, M.L.N., Murin, J.R., Morris Jones, P.H., Malpas, J.S. & Palmer, M.K. (1984) Adjuvant low dose radiation in childhood leukaemia/lymphoma. British Journal of Cancer, 50, 457-462.
66. Murphy, S.B., Bowman, W.P., Abromowitch, M., Mirro, J., Ochs, J., Rivera, G., Pui, C.H., Fairclough, D. & Berand, C.W. (1986) Results of treatment of advanced-stage Burkitt's lymphoma and B cell (Sig+) acute lymphoblastic leukaemia with high-dose fractionated cyclophosphamide and co-ordinated high-dose methotrexate and cytarabine. Journal of Clinical Oncology, 4, 1732-1739.
67. Murphy, S.B., Fairclough, D.L., Hutchinson, R.E. & Berard, C.W. (1989) Non-Hodgkin's lymphomas of childhood: analysis of the histology, staging and response to treatment of 338 cases at a single institution. Journal of Clinical Oncology, 7, 186-193.
68. Papadopoulos, E.B., Ladanyi, M., Emanuel, D., Mackinnon, S., Boulad, F., Carabasi, M.H., Casro-Malspina, H., Childs, B.H., Gillio, A.P., Small, T.N., Young, J.W., Kernan, N.A. & O'Reilly, R.J. (1994) Infusions of donor leukocytes to treat EBV associated lymphoproliferative disorders after allogenic bone marrow transplantation. New England Journal of Medicine, 330, 1185-1191.
69. Parkhurst, J.B., Foster, P., Johnson, S.F. & Leonard, J.C. (1998) Upstaging of non-Hodgkin's lymphoma in a child based on 67 Gallium scintigraphy. Journal of Pediatric Hematology and Oncology, 20, 174-176.
70. Patte, C., Bernard, A., Hartmann, O., Kalifa, C., Flamant, F. & Lemerle, J. (1986a) High-dose methotrexate and continuous infusion ara-C in children's non-Hodgkin's lymphoma: phase II studies and their future use in protocols. Pediatric Hematology/Oncology, 3, 11-18.
71. Patte, C., Kalifa, C., Flamant, F., Hartmann. O., Brugieres, L., Valteau-Couanet, D., Bayle, C., Caillaud, J.M. & Lemerle, J. (1992) Results of the LMT 81 protocol, a modified LS2A2 protocol with high-dose methotrexate, on 84 children with non-B cell lymphoblastic lymphoma. Medical and Pediatric Oncology, 20, 105-113.
72. +) and B-ALL. Medical Pediatric Oncology, 18, 397.
73. Patte, C., Philip, T., Rodary, C., Bernard, A., Zucker, J.M., Bernard, J.L., Robert, A., Rialland, X., Benz-Lemoine, E., Demeocq, F., Bayle, C. & Lemerle, J. (1986b) Improved survival rate in children with stage III and IV B cell non-Hodgkin's lymphoma and leukaemia using multi-agent chemotherapy: results of a study of 114 children from the French Pediatric Oncology Society. Journal of Clinical Oncology, 4, 1219-1226.
74. Patte, C., Philip, T., Rodary, C., Zucker, J.M., Behrendt, H., Gentet, J.C., Lamagnere, J.P., Otten, J., Dufillot, D., Pein, F., Caillou, B. & Lemerle, J. (1991) High survival rate in advanced stage B cell lymphoma and leukaemias without CNS involvement with a short intensive polychemotherapy: results from the French Pediatric Oncology Society of a randomized trial of 216 children. Journal of Clinical Oncology, 9, 123-132.
75. Philip, T., Armitage, O., Spitzer, G., Chauvin, F., Jagannnath, S., Cahn, J.Y., Colombat, P., Goldstone, A.H., Gorin, N.C. & Flesh, M. (1987a) High dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate or high grade non Hodgkins lymphoma. New England Journal of Medicine, 316, 1493-1498.
76. Philip, T., Bergeron, C. & Frappaz, D. (1996) Management of paediatric lymphoma. Baillieres Clinical Haematology, 9, 769-797.
77. Philip, T., Hartmann, O., Pinkerton, R., Zucker, J.M., Gentet, J.C., Lamagnere, J.P., Berhendt, H., Perel, Y., Otten, J. & Lutz, P. (1993) Curability of relapsed childhood B-cell non-Hodgkin's lymphoma after intensive first line therapy: a report from the Société Française d'Oncologie Pédiatrique. Blood, 81, 2003-2006.
78. Philip, T., Pinkerton, C.R., Biron, P., Ladjani, Y., Bouffet, E., Souillet, G., Philippe, N., Frappaz, D., Freycon, F., Chauvin, F. & Brunat-Montigny, M. (1987b) Effective multiagent chemotherapy in children with advanced B-cell lymphoma: who remains the high risk patient? British Journal of Haematology, 65, 159-164.
79. Philip, T., Pinkerton, R., Hartmann, O., Patte, C., Philip, I., Biron, P. & Favrot, M. (1986) The role of massive therapy with autologous bone marrow transplantation in Burkitt's lymphoma. Clinical Hematology, 15, 205-218.
80. Piira, T., Anderson, J.A., Meadows, A.T., Chilcote, R.R., Kadin, M. & Kjeldsberg, C.R. (1995) Primary mediastinal large cell lymphoma in children: a report from the Childrens Cancer Group. Pediatric Pathology and Laboratory Medicine, 15, 561-570.
81. Pinkerton, C.R., Hann, I., Eden, O.B., Gerrard, M., Berry, J. & Mott, M.G. (1991) Outcome in stage III non Hodgkins lymphoma (UKCCSG study NHL, 86): how much treatment is needed? British Journal of Cancer, 64, 583-587.
82. Pinto, A., Hutchinson, R.E., Grant, L.H., Trevenen, C.L. & Berard, C.W. (1990) Follicular lymphomas in pediatric patients. Modern Pathology 3, 308-313.
83. Popat, U., Przepiork, D., Champlin, R., Pugh, W., Amiu, K., Mehra, R. & Rodriguez, J. (1998) High dose chemotherapy for relapsed and refractory diffuse large B cell lymphoma: mediastinal localisation predicts for a favorable outcome. Journal of Clinical Oncology, 16, 63-69.
84. Pui, C.H., Ip, S., Kung, P., Dodge, R.K., Berard, C.W., Crist, W.M. & Murphy, S.B. (1987) High serum IL-2R levels are related to advanced disease and a poor outcome in childhood non-Hodgkin's lymphoma. Blood, 70, 624-628.
85. Pulford, K., Lamant, L., Morris, S.W., Butler, L., Wood, K., Stroud, D., Delsol, G. & Mason, D.Y. (1997) Detection of ALK and NPM-ALK proteins in normal and neoplastic cells with the monoclocal antibody AKL-1. Blood, 89, 1394-1404.
86. Reiter, A., Schrappe, M., Parwaresch, R., Henze, G., Muller-Weirich, S., Sauter, S., Sykora, K.W., Ludwig, W.-D., Gadner, H. & Riehm, H. (1995) Non-Hodgkin's lymphomas of childhood and adolescence: results of a treatment stratified for biologic subtypes and stages. A report of the Berlin-Frankfurt-Munster Group. Journal of Clinical Oncology, 13, 359-372.
87. Reiter, A., Schrappe, M., Tiemann, M., Parwaresch, R., Zimmerman, M., Yakisan, E., Dopfer, R., Bucsky, P., Mann, G., Gadner, H. & Reihm, H. (1994) Successful treatment strategy for Ki-1 anaplastic large-cell lymphoma of childhood: a prospective analysis of 62 patients enrolled in three consecutive Berlin-Frankfurt-Munster group studies. Journal of Clinical Oncology, 12, 899-908.
88. Remick, S.C., McSharry, J.J., Wolf, B.C. Blanchard, C.G., Eastman, A.Y., Wagner, H., Portuese, B., Wrighton, T., Powell, D., Pearson, T., Horton, J. & Ruckdeschel, J.C. (1993) Novel oral combination chemotherapy in the treatment of intermediate and high grade AIDS related NHL. Journal of Clinical Oncology, 11, 1691-1702.
89. Ribeiro, R.C., Pui, C., Murphy, S.B., Shuster, J.J., Hvisdala, E.V., Falletta, J., Link, M.P., Sullivan, M.P., Pick, T.E., Sandlund, J.T., Fairclough, D., Crist, W.M. & Berard, C.W. (1992) Childhood non-Hodgkins lymphomas of uncommon histology. Leukemia, 6, 761-765.
90. Romer, W., Hanauske, A.R., Ziegler, S., Thodmann, R., Weber, W., Fuchs, C., Enne, W., Herz, M., Nerl, C., Garbrecht, M. & Schwaiger, M. (1998) Positron emission tomography in non Hodgkins lymphoma: assessment of chemotherapy with fluorodeoxyglucose. Blood, 91, 4464-4471.
91. Ryalls, M.R., Pinkerton, C.R., Meller, S.T., Talbot, D. & McElwain, T.J. (1992) High dose methylprednisolone sodium succinate as a single agent is relapsed childhood acute lymphoblastic leukaemia. Medical and Pediatric Oncology, 20, 119-123.
92. Sandlund, J., Pui, C., Santana, V., Mahmoud, H., Roberts, W.M., Morris, S., Raimondi, S., Ribiero, R., Crist, W.M., Lin, J.-S., Mao, L., Berard, C.W. & Hutchinson, R.E. (1994a) Clinical features and treatment outcome for children with CD30-1 large-cell non-Hodgkin's lymphoma. Journal of Clinical Oncology, 12, 895-898.
93. Sandlund, J.T., Crist, W.M., Abromowitch, M., Fairclough, D., Berard, C.W., Rafferty, M. & Pui, C.H. (1991) Pleural effusions associated with a poor treatment outcome in stage III small non-cleaved cell lymphoma. Leukaemia, 5, 71-74.
94. Sandlund, J.T., Downing, J.R. & Crist, W.M. (1996) Non-Hodgkin's lymphoma in childhood. New England Journal of Medicine, 334, 1238-1248.
95. Sandlund, J.T., Pui, C.H. & Roberts, W.M. (1994b) Clinicopathologic features and treatment outcome of children with large-cell lymphoma and the t(2;5) (p23;q35). Blood, 84, 2467-2471.
96. Santana, V.M., Abromowitch, M., Sandlund, J.T., Behm, F.G., Ayers, G.D. & Roberson, P.K. (1993) MACOP-B treatment in children and adolescents with advanced diffuse large-cell non-Hodgkin's lymphoma. Leukaemia, 7, 187-191.
97. Schwenn, M.R., Blattner, S.R., Lynch, E., Weinstein, H.J. (1991) HIC-COM: a 2 month intensive chemotherapy regimen for children with stage III and IV Burkitt's lymphoma and B-cell acute lymphoblastic leukaemia. Journal of Clinical Oncology, 9, 133-138.
98. Shepherd, S.F., A'Herne, R.P. & Pinkerton, C.R. (1995) Childhood T cell lymphoblastic lymphoma: does early resolution of mediastinal mass predict for final outcome? British Journal of Cancer, 72, 752-756.
99. Seidermann, K., Meyer, U., Jansen, P., Yaksin, E., Rieske, K., Fuhrer, M., Kremens, B., Schrappe, M. & Reiter, A. (1998) Impaired renal function and tumor lysis syndrome in pediatric patients with non-Hodgkins lymphoma and B ALL: observations from the BFM trials. Klinische Pädiatrie, 210, 279-284.
100. Sparano, J.A., Wiernik, P., Hu, X., Sarto, C., Schwartz, E.L., Soeiro, R., Henry, D.H., Mason, B., Ratech, H. & Dutcher, J.P. (1996) Pilot trial of infusional cyclophosphamide, doxorubicin and etoposide plus didanosine and filgrastim in patients with human immunodeficiency virus associated non-Hodgkin's lymphoma. Journal of Clinical Oncology, 14, 3026-3035.
101. Swinnen, L.J., Mullen, G.M., Carr, T.J., Constanzo, M.R. & Fisher, R.I. (1995) Aggressive treatment of postcardiac transplant lympho-proliferation. Blood, 86, 3333-3340.
102. Sullivan, M.P. & Ramirez, I. (1985) Curability of Burkitt's lymphoma with high-dose cyclophosphamide-high-dose methotrexate therapy and intrathecal chemoprophylaxis. Journal of Clinical Oncology, 3, 627-635.
103. Tubergen, D., Krailo, M.D., Meadows, A.T., Rosenstock, J., Kadin, M., Morse, M., King, D., Steinherz, P.G. & Kersey, J.H. (1995) Comparison of treatment regimens for pediatric lymphoblastic non-Hodgkin's lymphoma: a Children's Cancer Group Study. Journal of Clinical Oncology, 13, 1368-1376.
104. Van den Berg, H., Zsiros, J., Veneberg, A., Schutten, N.J., Slater, R.M. & Behrendt, H. (1998) Favourable outcome after 1 year treatment of childhood T cell lymphoma/T cell acute lymphoblastic leukemia. Medical and Pediatric Oncology, 30, 46-51.
105. +) in childhood. Medical and Pediatric Oncology, 21, 402-410.
106. Vose, J.M. (1998) Current approaches in the management of non-Hodgkin's lymphoma. Seminars in Oncology, 25, 483-491.
107. Wheeler, K.C. & Chessells, J.M. (1990) UKALL X, an effective treatment for stage III mediastinal non Hodgkin's lymphoma. Archives of Diseases in Childhood, 65, 252-254.
108. Wright, D., McKeever, P. & Carter, R. (1997) Childhood non-Hodgkin's lymphoma in the United Kingdom: findings from the UK Childrens Cancer Study Group. Journal of Clinical Pathology, 50, 128-134.
109. Zucker, J.M., Caillaud, J.M., Vanel, D. & Gerard-Marchant, R. (1980) Malignant histiocytosis in childhood: clinical study and therapeutic results in 22 cases. Cancer, 45, 2821-2829.