Grepafloxacin vs pneumococci resistant to fluoroquinolones by a putative efflux mechanism

Drugs

Volumn 58, Issue SUPPL. 2, 1999, Pages 117-118

  Brenwald, Nigel P ^a   Gill, Martin J ^b   Wise, Richard ^a  

^a CITY HOSPITAL   (United Kingdom)

^b UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; CLINAFLOXACIN; GREPAFLOXACIN; LEVOFLOXACIN; NORFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SPARFLOXACIN;

AGAR GEL DIFFUSION; ANTIBIOTIC RESISTANCE; BACTERIAL GENE; BACTERIUM MUTANT; CONFERENCE PAPER; CONTROLLED STUDY; DRUG TRANSPORT; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POLYMERASE CHAIN REACTION; STREPTOCOCCUS PNEUMONIAE;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS PNEUMONIAE;

EID: 0032707944     PISSN: 00126667     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003495-199958002-00025     Document Type: Conference Paper

References (5)

1. Pan X, Ambler J, Mehtar S, et al. Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae. Antimicrob Agents Chemother 1996; 40: 2321-6
2. Perichon B, Tankovic J, Courvalin P. Characterisation of a mutant in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother 1997; 41: 1166-7
3. Brenwald NP, Gill MJ, Wise R. The effect of reserpine, an inhibitor of multi-drug efflux pumps, on the in-vitro susceptibilities of fluoroquinolone-resistant strains of Streptococcus pneumoniae to norfloxacin. J Antimicrob Chemother 1997; 40: 458-60
4. Zeller V, Janoir C, Kitzis M, et al. Active efflux as a mechanism of resistance to ciprofloxacin in Streptococcus pneumoniae. Antimicrob Agents Chemother 1997; 41: 1973-8
5. Gill MJ, Brenwald NP, Wise R. Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother 1999; 43: 187-9