Synthesis of valproate, valerate, and 1-methyl-1, 4-dihydropyridyl-3- carbonyloxy ester derivatives of hantzsch 1,4-dihydropyridines as potential prodrugs and their evaluation as calcium channel antagonist and anticonvulsant agents

Drug Development Research

Volumn 48, Issue 1, 1999, Pages 26-37

  Yiu, Sai Hay ^a   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

1,4 dihydropyridine ester prodrugs; Calcium channel antagonists(anticonvulsants

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 1,4 DIHYDROPYRIDINE DERIVATIVE; 4 AMINOBUTYRIC ACID; CALCIUM CHANNEL BLOCKING AGENT; ESTER DERIVATIVE; FELODIPINE; FLUNARIZINE; NIMODIPINE; PENTETRAZOLE; PHENYTOIN; VALERIC ACID DERIVATIVE; VALPROIC ACID; VALPROIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EPILEPSY; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PARTITION COEFFICIENT; STRUCTURE ACTIVITY RELATION;

EID: 0032706951     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2299(199909)48:1<26::AID-DDR4>3.0.CO;2-M     Document Type: Article

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