Testosterone and testosterone free index in mild ankylosing spondylitis: Relationship with bone mineral density and vertebral fractures

Journal of Rheumatology

Volumn 26, Issue 11, 1999, Pages 2414-2417

  Mitra, Devashis ^a,b   Elvins, David M ^a   Collins, Anthony J ^a  

^a ROYAL NATIONAL HOSPITAL FOR RHEUMATIC DISEASES   (United Kingdom)

^b GREENVILLE HOSPITAL SYSTEM   (United States)

Author keywords

Ankylosing spondylitis; Bone mineral density; Fractures; Testosterone

Indexed keywords

FOLLITROPIN; LUTEINIZING HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; ANKYLOSING SPONDYLITIS; ARTICLE; BONE DENSITY; BONE MINERAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DUAL ENERGY X RAY ABSORPTIOMETRY; HUMAN; HYPOGONADISM; MAJOR CLINICAL STUDY; MALE; OSTEOPENIA; PRIORITY JOURNAL; SPINE RADIOGRAPHY; TESTOSTERONE BLOOD LEVEL; VERTEBRA FRACTURE;

ADULT; BONE DENSITY; FOLLICLE STIMULATING HORMONE; HUMANS; MALE; SEX HORMONE-BINDING GLOBULIN; SPINAL FRACTURES; SPONDYLITIS, ANKYLOSING; TESTOSTERONE;

EID: 0032705666     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Will R, Palmer R, Bhalla AK, Calin A. Osteoporosis in early ankylosing spondylitis: a primary pathological event? Lancet 1989;2:1483-5.
2. Devogelaer JP, Maldague B, Malghem J, de Deuxchaisnes CN. Appendicular and vertebral bone mass in ankylosing spondylitis. Arthritis Rheum 1992;35:1062-7.
3. Mitra D, Ring EFJ, Bhalla AK, Collins AJ. Osteoporosis associated with ankylosing spondylitis. In: Ring EFJ, editor. Current research in osteoporosis and bone mineral measurement. III. London: British Institute of Radiology; 1994;42-3.
4. Mullaji AB, Upadhyay SS, Ho EKW. Bone mineral density in ankylosing spondylitis. J Bone Joint Surg 1994;76B:660-5.
5. Wilkinson M, Bywaters EGL. Clinical features and course of ankylosing spondylitis. Ann Rheum Dis 1958;17:209-28.
6. Hunter T, Dubo H. Spinal fractures complicating ankylosing spondylitis. Ann Intern Med 1978;88:546-9.
7. Hunter T, Dubo HIC. Spinal fractures complicating ankylosing spondylitis: a long term study. Arthritis Rheum 1983;26:751-9.
8. Hanson CA, Shagrin JW, Duncan H. Vertebral osteoporosis in ankylosing spondylitis. Clin Orthop Rel Res 1971;74:59-64.
9. Dilsen N. Romatizmal hastaliklarda vertebral osteoporoz hakkinda [Vertebral osteoporosis in rheumatic diseases]. Turk Tip Cemiyeti Mecumuasi 1964;30:362-70.
10. Ralston SH, Urquhart GDK, Brzeski M, Sturrock RD. Prevalence of vertebral compression fractures due to osteoporosis in ankylosing spondylitis. BMJ 1990;300:563-5.
11. Cooper C, Carbone L, Michel CJ, Atkinson EJ, O'Fallon WM, Melton IJ III. Fracture risk in patients with ankylosing spondylitis: a population based study. J Rheumatol 1994;21:1877-84.
12. Donnelly S, Doyle DV, Denton A, Rolfe I, McCloskey EV, Spector TD. Bone mineral density and vertebral compression fracture rates in ankylosing spondylitis. Ann Rheum Dis 1994;53:117-21.
13. Francis RM, Peacock M, Aaron JE, et al. Osteoporosis in hypogonadal men: role of decreased plasma 1,25-dihydroxyvitamin D, calcium malabsorption and low bone formation. Bone 1986;7:261-8.
14. Winks CS, Felts WJL. Effects of castration on the hone structure of male rats: a model of osteoporosis. Calcif Tissue Int 1980;32:77-82.
15. Jackson JA, Kleerkoper M, Parfitt AM, Rao DS, Villaneuva AR, Frame B. Bone histomorphometry in hypogonadal and eugonadal men with spinal osteoporosis. J Clin Endocrinol Metab 1987;65:53-8.
16. Delmas P, Meunier PJ. L'osteoporose au cours du syndrome de Klinefelter. Nouvelle Presse Med 1981;10:687-90.
17. Smith DAS, Walker MS. Changes in plasma steroids and bone density in Klinefelter's syndrome. Calcif Tissue Res 1977;22S:225-8.
18. Foresta C, Busnardo B, Ruzza G, Zanatta G, Mioni R. Lower calcitonin levels in young hypogonadal men with osteoporosis. Hormone Metabolic Res 1983;15:206-7.
19. Spector TD, Ollier W, Perry LA, Silman AJ, Thompson PW, Edwards A. Free and serum testosterone levels in 276 males: a comparative study of rheumatoid arthritis, ankylosing spondylitis and healthy controls. Clin Rheumatol 1988;8:37-41.
20. Gordon D, Beastall GH, Thomson JA, Sturrock RD. Androgenic status and sexual function in males with rheumatoid arthritis and ankylosing spondylitis. Q J Med 1986;231:671-9.
21. Spector TD, Perry LA, Tubb G, Silman AJ, Huskisson EC. Low free testosterone levels in rheumatoid arthritis. Ann Rheum Dis 1988;47:65-8.
22. Tapia-Serrano R, Jimenez-Balderas FL, Murrieta S, Bravo-Gatica C, Guerra R, Mintz G. Testicular function in active ankylosing spondylitis: therapeutic response to human chorionic gonadotrophin. J Rheumatol 1991;18:841-8.
23. Chevallard M, Angelini M, Ambrosi B. Travaglini P, Carrabba M. Sex hormone concentrations in male patients with ankylosing spondylitis: preliminary report [letter]. Clin Rheumatol 1987;6:609-10.
24. Borbas E, Feher K, Hejj G, Gaal M, Balint G. Steroid hormone levels in peripheral sera of patients with ankylosing spondylitis [abstract]. EULAR symposium, "Seronegative Polyarthritis," Oct. 16-18, 1986, Rome, Italy. Clin Exp Rheumatol 1987;5 Suppl 1:120.
25. Dougados M, Nahoul K, Brasseur B, Amor B. Sex hormone levels in ankylosing spondylitis [abstract]. EULAR symposium, "Seronegative Polyarthritis." Oct. 16-18, 1986, Rome, Italy. Clin Exp Rheumatol 1987;5 Suppl 1:121.
26. Khun MA, van der Linden SM. AS and other spondyloarthropathies. Rheum Dis Clin North Am 1990;16:551-79.
27. Macrae IF, Wright V. Measurement of back movement. Ann Rheum Dis 1969;28:584-93.
28. Taylor HG, Wardle T, Beswick EJ, Dawes PT. The relationship of clinical and laboratory measurements to radiological change in ankylosing spondylitis. Br J Rheumatol 1991;330-5.
29. McCloskey EV, Spector TD, Eyres KS, et al. The assessment of vertebral fracture: a method for use in population studies and clinical trials. Osteoporosis Int 1993;3:138-47.
30. Bremner WJ, Vitiello MV, Prinz PN. Loss of circadian rhythmycity in blood testosterone levels with ageing in normal men. J Clin Endocrinol Metab 1983;56:1278-81.
31. Marhoffer W, Stracke H, Masoud I, et al. Evidence of impaired cartilage/bone turnover in patients with active ankylosing spondylitis. Ann Rheum Dis 1995;54:556-9.
32. Szcjnfeld VL. Monier-Faugere MC, Bognar BJ, Ferraz MB, Malluche HH. Systemic osteopenia and mineralization defect in patients with ankylosing spondylitis. J Rheumatol 1997;24:683-8.
33. Franck H, Keck E. Serum osteocalcin and vitamin D metabolites in patients with ankylosing spondylitis. Ann Rheum Dis 1993;52:343-6.
34. Ekenstain EA, Sverker L, Hallgren R. Serum osteocalcin in rheumatoid arthritis and other inflammatory arthritides: relation between inflammatory activity and the effect of glucortocoids and remission inducing drugs. Ann Rheum Dis 1986;45:484-90.