Measurements of iron status and survival in African iron overload

South African Medical Journal

Volumn 89, Issue 9, 1999, Pages 966-972

  MacPhail, A Patrick ^c   Mandishona, Eberhard M ^c   Bloom, Peter D ^c   Paterson, Alan C ^a   Rouault, Tracey A ^b   Gordeuk, Victor R ^c  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; GAMMA GLUTAMYLTRANSFERASE; IRON; LIVER ENZYME; TRANSFERRIN;

ADULT; AGED; ARTICLE; BEER; CLINICAL ARTICLE; CORRELATION FUNCTION; FEMALE; FERRITIN BLOOD LEVEL; FOLLOW UP; HEPATOMEGALY; HUMAN; HUMAN TISSUE; IRON INTAKE; IRON OVERLOAD; LIVER BIOPSY; LIVER CIRRHOSIS; LIVER FIBROSIS; MALE; SURVIVAL RATE;

ADULT; AFRICAN AMERICANS; AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; BEER; BIOPSY, NEEDLE; BLOOD CHEMICAL ANALYSIS; DATA INTERPRETATION, STATISTICAL; FEMALE; FERRITINS; HEPATOMEGALY; HUMANS; IRON OVERLOAD; IRON, DIETARY; LIVER; MALE; MIDDLE AGED; SOUTH AFRICA; SURVIVAL RATE; TRANSFERRIN;

EID: 0032704555     PISSN: 02569574     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Strachan AS. Haemosiderosis and haemochromatosis in South African natives with a comment on the aetiology of haemochromatosis. MD thesis, University of Glasgow, 1929.
2. Bothwell TH, Bradlow BA. Siderosis in the Bantu. A combined histopathological and chemical study. Archives of Pathology and Laboratory Medicine 1960; 70: 279-292.
3. Isaacson C, Seftel HC, Keeley KJ, Bothwell TH. Siderosis in the Bantu: The relationship between iron overload and cirrhosis. J Lab Clin Med 1961; 58: 845-853.
4. Bothwell TH, Isaacson C. Siderosis in the Bantu, a comparison of incidence in males and females. BMJ 1962; 1: 1522-1524.
5. Seftel HC, Keeley KJ, Isaacson C, Bothwell TH. Siderosis in the Bantu: the clinical incidence of haemochromatosis in diabetic subjects. J Lab Clin Med 1961; 58: 837-844.
6. Lynch SR, Berlowitz I, Seftel HC, et al. Osteoporosis in Johannesburg Bantu males, its relationship to siderosis and ascorbic acid deficiency. Am J Clin Nutr 1967; 20: 799-807.
7. MacPhail AP, Simon MO, Torrance JD, Charlton RW, Bothwell TH, Isaacson C. Changing patterns of dietary iron overload in black South Africans. Am J Clin Nutr 1979; 32: 1272-1278.
8. Swift PJ. Dietary iron overload as a cause of idiopathic cardiomyopathy in South Africa. S Afr Med J 1996; 86: C17-C21.
9. Bothwell TH, Abrahams C, Bradlow PA, Charlton RW. Idiopathic and Bantu siderosis. Archives of Pathology and Laboratory Medicine 1965; 79: 163-168.
10. Brink B, Disler P, Lynch S, Jacobs P, Charlton R, Bothwell T. Patterns of iron storage in dietary iron overload and idiopathic haemochromatosis. J Lab Clin Med 1976; 88: 725-731.
11. Bothwell TH, Seftel H, Jacobs P, Torrance JD, Baumslag N. Iron overload in Bantu subjects. Studies on the availability of iron in Bantu beer. Am J Clin Nutr 1964; 14: 47-51.
12. Buchanan WM. Bantu siderosis with a special reference to Rhodesian Africans. University College of Rhodesia, Faculty of Medicine, Research Lecture Series 1967; 1: 5-30.
13. Gordeuk VR, Boyd RD, Brittenham GM. Dietary iron overload persists in rural sub-Saharan Africa. Lancet 1986; 1: 1310-1313.
14. Gordeuk VR, Mukiibi J, Hasstedt SJ, et al. Iron overload in Africa: interaction between a gene and dietary iron content. N Engl J Med 1992; 326: 95-100.
15. Moyo VM, Mandishona E, Hasstedt SJ, et al. Evidence of genetic transmission in African iron overload. Blood 1998; 91:1076-1082.
16. Gordeuk VR. Hereditary and nutritional iron overload. Balliere's Clin Haematol 1992; 5: 169-186.
17. Finch CA. The detection of iron overload. N Engl J Med 1982; 307: 1702-1703.
18. Boehringer Mannheim. Methods of Biochemical Analysis and Food Analysis. Mannheim, Germany: Boehringer Mannheim GmbH, 1989: 40-42.
19. Scheuer PJ, Williams R, Muir AR. Hepatic pathology in relatives of patients with haemochromatosis. J Path Bact 1962; 84: 53-64.
20. Torrance JD, Bothwell TH. A simple technique for measuring storage iron concentrations in formalinised liver samples. S Afr J Med Sci 1968; 33: 9-11.
21. Bassett ML, Halliday JW, Powell LW. Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatology 1986; 6: 24-29.
22. International Committee for Standardisation in Haematology (Iron Panel). Recommendations for measurement of serum iron in human blood. Br J Haematol 1978; 38: 291-294.
23. International Committee for Standardisation in Haematology (Iron Panel). The measurement of total and unsaturated iron-binding capacity in serum. Br J Haematol 1978; 38: 281-290.
24. Conradie JD, Mbhele BEL. Quantitation of serum ferritin by an enzyme-linked immunosorbent assay (ELISA). S Afr Med J 1980; 57: 282-287.
25. Prieto J, Barry M, Sherlock S. Serum ferritin in patients with iron overload and with acute and chronic liver disease. Gastroenterology 1975; 68: 523-533.
26. Ford C, Wells FE, Rogers JN. Assessment of iron status in association with excess alcohol consumption. Ann Clin Biochem 1995; 32: 527-531.
27. Denson KW, Bowers EF. The determination of ascorbic acid in white blood cells: a comparison of white blood cell ascorbic acid and phenolic acid excretion in elderly patients. Clin Sci 1961; 21: 157-162.
28. Worwood SJ, Jacobs A, Mclaren C, Ricketts C, Economidou J. Binding of serum ferritin to concavalin A: Patients with homozygous ß thalassaemia and transfusional iron overload. Br J Haematol 1980; 46: 409-416.
29. Summers KM, Halliday JW, Powell LW. Identification of homozygous hemochromatosis subjects by measurement of hepatic iron index. Hepatology 1990; 12: 20-25.
30. Sallie RW, Reed WD, Shilkin KB. Confirmation of the efficacy of hepatic tissue iron index in differentiating genetic haemochromatosis from alcoholic liver disease complicated by alcoholic haemosiderosis. Gut 1991; 32: 207-210.
31. Chapman RW, Morgan MY, Laulicht M, et al. Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis. Dig Dis Sci 1982; 27: 909-916.
32. Goldberg DM. Structural, functional, and clinical aspects of gamma-glutamyltransferase. CRC Critical Review Clin Lab Sci 1980; 12: 1-58.
33. Mandishona E, MacPhail AP, Gordeuk VR, et al. Dietary iron overload as a risk factor for hepatocellular carcinoma in black Africans. Hepatology 1998; 27: 1563-1567.
34. Gordeuk VR, McLaren CE, MacPhail AP, Deichsel G, Bothwell TH. Associations of iron overload in Africa with hepatocellular carcinoma and tuberculosis: Strachan's 1929 thesis revisited. Blood 1996; 87: 3470-3476.
35. Nesamvuni AE. Iron status in relation to dietary iron intake in adult Blacks residing in the Cape Peninsula. M.Nutr. thesis, University of the North, 1995.
36. MacPhail AP, Derman DP, Bothwell TH, et al. Serum ferritin concentrations in black miners. S Afr Med J 1979; 55: 758-760.