Altered adaptive behaviour expressed in an open-field paradigm in experimental hepatic encephalopathy

Behavioural Brain Research

Volumn 106, Issue 1-2, 1999, Pages 165-173

  Apelqvist, Gustav ^a   Hindfelt, Bengt ^a   Andersson, Gunnar ^b   Bengtsson, Finn ^a,c  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b Pharmacia Oncology Immunology   (Sweden)

^c LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Hepatic encephalopathy; Locomotion; Open field behaviour; Portacaval shunt; Rearing

Indexed keywords

ADAPTIVE BEHAVIOR; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; EXPLORATORY BEHAVIOR; HABITUATION; HEPATIC ENCEPHALOPATHY; LEARNING; MALE; NONHUMAN; OPEN FIELD BEHAVIOR; PHYSICAL ACTIVITY; PORTOCAVAL SHUNT; PRIORITY JOURNAL; RAT;

ADAPTATION, PSYCHOLOGICAL; ANIMALS; BEHAVIOR, ANIMAL; BODY WEIGHT; CHRONIC DISEASE; EXPLORATORY BEHAVIOR; HABITUATION, PSYCHOPHYSIOLOGIC; HEPATIC ENCEPHALOPATHY; MALE; MOTOR ACTIVITY; PORTACAVAL SHUNT, SURGICAL; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 0032703986     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(99)00104-7     Document Type: Article

References (28)

1. Adams RD, Foley JM. The neurological disorder associated with liver disease. In: Merritt HH, Hare CC, editors. Metabolic and Toxic Disease of the Nervous System, vol. 32. Baltimore, MD: Williams & Wilkins, 1953:198-237.
2. Apelqvist G, Hindfelt B, Andersson G, Bengtsson F. Central versus peripheral spontaneous behavioral abnormalities in experimental hepatic encephalopathy. Physiol Behav 1997;61:851-6.
3. Apelqvist G, Hindfelt B, Andersson G, Bengtsson F. Diurnal and gender effects by chronic portacaval shunting in rats on spontaneous locomotor and rearing activities in an open-field. Behav Brain Res 1998;93:25-32.
4. Atkinson M, Goligher J. Recurrent hepatic coma treated by colectomy and ileorectal anastomosis. Lancet 1960;i:461-4.
5. Bengtsson F. Chronic portal-systemic encephalopathy. An experimental study with special reference to brain serotonin. Thesis Bulletin No. 66, Department of Surgery, Lund University, Lund, Sweden, 1987, 90 pp..
6. Bengtsson F. Neurotransmission failure in hepatic encephalopathy involving the combined action of different brain tryptophanrelated pathology: a speculative synthesis. In: Ishiguro I, Kido R, Nagatsu T, Nagamura Y, Ohta Y, editors. Advances in tryptophan research. Toyoake, Japan: Fujita Health University Press, 1992:303-8.
7. Bengtsson F, Bugge M, Brun A, Falck B, Henriksson KG, Nobin A. The impact of time after portacaval shunt in the rat on behavior, brain serotonin, and brain and muscle histology. J Neurol Sci 1988;83:109-22.
8. Bengtsson F, Nobin A, Falck B, Gage FH, Jeppsson B. Portacaval shunt in the rat: selective alterations in behavior and brain serotonin. Pharmacol Biochem Behav 1986;24:1611-6.
9. Bergqvist PBF. Tryptophan-related neurotransmission in the brain. Disturbances associated with experimental hepatic encephalopathy. Thesis, Department of Clinical Pharmacology, Lund University, Lund, Sweden, 1997:114 pp.
10. Bucci L, Cardelli M, Chiavarelli R, Massotti M, Morisi G. Behavioral, electroencephalographic, and biochemical changes in porta-cava shunted rats. Int J Neurosci 1980;10:129-34.
11. Campbell A, Jeppsson B, James JH, Ziparo V, Fischer JE. Spontaneous motor activity increases after portacaval anastomosis in rats. Pharmacol Biochem Behav 1984;20:875-8.
12. Conn HO, Lieberthal MM. The Hepatic Coma Syndromes and Lactulose. Baltimore: Williams & Wilkins, 1979 360 pp.
13. Elsass P, Lund Y, Ranek L. Encephalopathy in patients with cirrhosis of the liver. A neuropsychological study. Scand J Gastroenterol 1978;13:241-7.
14. Kelley AN. Locomotor activity and exploration. In: Sahgal A, editor. Behavioural Neuroscience. A Practical Approach, vol. 2. Oxford: Oxford University Press, 1993:1-22.
15. Lee SH, Fisher B. Portocaval shunt in the rat. Surgery 1961;50:668-72.
16. Lozeva V, Anttila E, Tuominen RK, Hippeläinen M, Männistö PT, Tuomisto L. Hypothalamic histamine, growth rate, plasma prolactine and growth hormone levels in rats with long-term portacaval anastomosis. Inflamm Res 1999;48:81-5.
17. Martin JR. Discordant motor activity levels of portacaval shunted rats in runway and swim tests. Behav Neurosci 1986;3:427-30.
18. Martin JR, Baettig K, Bircher J. Maze patrolling, open-field behavior and runway activity following experimental portacaval anastomosis in rats. Physiol Behav 1980;25:713-9.
19. Martin JR, Dedek J, Driscoll P. Portacaval anastomosis in rats: effects on behavior and brain serotonin metabolism. Pharmacol Biochem Behav 1983;18:269-72.
20. Martin JR, Oettinger R, Bättig K. Behavioral effects of experimental portacaval anastomosis measured in dashiell and radial tunnel maze configurations. Physiol Behav 1986;38:21-4.
21. Mousseau DD, Butterworth RF. Current theories on the pathogenesis of hepatic encephalopathy. Exp Biol Med 1994;206:329-44.
22. Rehnström S, Siemert G, Hansson G, Vang J. Chronic hepatic encephalopathy. A psychometrical study. Scand J Gastroenterol 1977;12:305-11.
23. Resnick R, Ishihara A, Chalmers T, Schimmel E. The Boston inter-hospital liver group: a controlled trial of colon bypass in chronic hepatic encephalopathy. Gastroenterology 1968;54:1057-69.
24. Rikkers L, Jenko P, Rudman D, Freides D. Subclinical hepatic encephalopathy: detection, prevalence and relationship to nitrogen metabolism. Gastroenterology 1978;75:462-9.
25. Schröder R, Müller O, Bircher J. The portacaval and splenocaval shunt in the normal rat. A morphometric and functional reevaluation. J Hepatol 1985;1:107-23.
26. Simmons F, Goldstein H, Boyle J. A controlled clinical trial of lactulose in hepatic encephalopathy. Gastroenterology 1970;59:827-32.
27. Tarter RE, Hegedus AM, Van Thiel DH. Neuropsychiatric sequelae of portal-systemic encephalopathy: a review. Int J Neurosci 1984;24:203-16.
28. Tricklebank MD, Smart JL, Bloxam DL, Curzon G. Effects of chronic experimental liver dysfunction and L-tryptophan on behavior in the rat. Pharmacol Biochem Behav 1978;9:181-9.