Sodium channels: From mechanisms to medicines?

Brain Research Bulletin

Volumn 50, Issue 5-6, 1999, Pages 309-310

  Waxman, Stephen G ^a,b   Wood, John N ^c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SODIUM CHANNEL;

ACTION POTENTIAL; DORSAL ROOT; NERVE INJURY; NOCICEPTION; NOCICEPTIVE RECEPTOR; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0032701384     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(99)00158-6     Document Type: Review

References (10)

1. Akopian A.N., Sivilotti L., Wood J.N. A tetrodotoxin-resistant sodium channel expressed by C-fibre associated sensory neurons. Nature. 379:1996;257-262.
2. + channel III and SNS gene expression in spinal sensory neurons. NeuroReport. 8:1997;2331-2335.
3. Cummins T.R., Waxman S.G. Down-regulation of tetrodotoxin-resistant sodium currents and upregulations of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury. J. Neurosci. 17:(10):1997;3503-3514.
4. Dib-Hajj S.D., Black J.A., Felts P., Waxman S.G. Down-regulation of transcripts for Na channel α-SNS in spinal sensory neurons following axotomy. Proc. Nat. Acad. Sci. USA. 93:1996;14950-14954.
5. Dib-Hajj S.D., Tyrrell L., Black J.A., Waxman S.G. NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy. Proc. Nat. Acad. Sci. USA. 95:1998;8963-8968.
6. Fitzgerald, E.; Okuse, K.; Dolphin, A.; Wood, J. N.; Moss, S. Cyclic AMP-dependent phosphorylation of the tetrodotoxin-resistant voltage-dependent sodium channel, SNS. J. Physiol. (Lond.) 516(Pt 2):433-446.
7. Fjell J., Cummins T.R., Dib-Hajj S.D., Fried K., Black J.A., Waxman S.G. Differential role of DGNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons. Molec. Brain Res. 67:1999;267-282.
8. Okuse K., Chaplan S.R., McMahon S., Luo Z.D., Calcutt N.A., Scott B.P., Akopian A.N., Wood J.N. Regulation of expression of the sensory neuron specific sodium channel SNS in inflammatory and neuropathic pain. Mol. Cell Neurosci. 10:1997;96-207.
9. Sangameswaran L., Delgado S.G., Fish L.M., Koch B.D., Jakeman L.B., Steward G.R., Sze P., Hunter J.C., Eglen R.M., Herman R.C. Structure and function of a novel voltage-gated tetrodotoxin-resistant sodium channel specific to sensory neurons. J. Biol. Chem. 271:1996;5953-5956.
10. Tate S., Benn S., Hick C., Trezise D., John V., Mannion R.J., Costigan M., Plumpton C., Grose D., Gladwell Z., Kendall G., Dale K., Bountra C., Woolf C.J. Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons. Nature Neurosci. 1:1998;653-655.