Activation of plasma procarboxypeptidase U in different mammalian species points to a conserved pathway of inhibition of fibrinolysis

Thrombosis and Haemostasis

Volumn 82, Issue 6, 1999, Pages 1718-1721

  Schatteman, Katinka A ^a   Goossens, Filip J ^a   Scharpé, Simon S ^a   Hendriks, Dirk F ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Animal species; Carboxypeptidase U; Coagulation; Fibrinolysis

Indexed keywords

CARBOXYPEPTIDASE; ENZYME PRECURSOR; THROMBIN; THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR; THROMBOMODULIN; UNCLASSIFIED DRUG;

ARTICLE; BLOOD CLOT LYSIS; BLOOD CLOTTING; CONTROLLED STUDY; DOG; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBRINOLYSIS; GUINEA PIG; HUMAN; MAMMAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; SPECIES DIFFERENCE; SWINE; TIME;

EID: 0032700758     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1614904     Document Type: Article

References (24)

1. Davie EW, Fujikawa K, Kisiel W. The coagulation cascade: initiation, maintenance, and regulation. Biochemistry 1991; 30: 10363-70.
2. Francis CW, Marder VJ. Concepts of clot lysis. Ann Rev Med 1986; 37: 187-204.
3. 2-plasmin inhibitor and its deficiency states. J Lab Clin Med 1988; 112: 671-8.
4. Rosenberg RD, Damus PS. The purification and mechanism of action of human antithrombin-heparin cofactor. J Biol Chem 1973; 248: 6490-505.
5. Kisiel W. Human plasma protein C. J Clin Invest 1979; 64: 761-9,
6. Hendriks D, Scharpé S, van Sande M, Lommaert MP. Characterisation of a carboxypeptidase in human serum distinct from carboxypeptidase N. J Clin Chem Clin Biochem 1989; 27: 277-85.
7. Hendriks D, Wang W, Scharpé S, Lommaert M, van Sande M. Purification and characterization of a new arginine carboxypeptidase in human serum. Biochim Biophys Acta 1990; 1034: 86-92,
8. Campbell W. Okada H. An arginine specific carboxypeptidase generated in blood during coagulation or inflammation which is unrelated to carboxypeptidase N or its subunits. Biochem Biophys Res Commun 1989; 162: 933-9.
9. Hendriks D, Scharpé S, van Sande M. Partial purification and characterisation of a new arginine carboxypeptidase from human serum. J Clin Chem Clin Biochem 1988; 26: 305.
10. Hendriks D, Scharpé S, van Sande M, Lommaert MP. A labile enzyme in fresh human serum interferes with the assay of carboxypeptidase N. Clin Chem 1989; 35: 177.
11. Eaton D, Malloy B, Tsai S, Henzel W, Drayna D. Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma. J Biol Chem 1991; 266: 21833-8.
12. Bajzar L, Morser J, Nesheim M. TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex. J Biol Chem 1996; 271: 16603-8.
13. Bajzar L, Manuel R, Nesheim M. Purification and characterization of TAFI. a thrombin-activable fibrinolysis inhibitor. J Biol Chem 1995; 270: 14477-84.
14. Bajzar L, Nesheim M, Tracy P. The profibrinolytic effect of protein C in clots formed from plasma is TAFI-dependent. Blood 1996; 88: 2093-100.
15. Redlitz A, Nicolini F, Malycky J, Topol E, Plow E. Inducible carboxypeptidase activity: a role in clot lysis in vivo. Circulation 1996; 93: 1328-30.
16. Minnema M, Friederich P, Levi M, von dem Borne P, Mosnier L, Meijers J, et al. Enhancement of rabbit jugular vein thrombolysis by neulralization of factor XI: in vivo evidence for a role of factor XI as an antifibrinolytic factor. J Clin Invest 1998; 101: 10-4.
17. Broze G, Higuchi D. Coagulation-dependent inhibition of fibrinolysis: Role of carboxypeptidase-U and the premature lysis of clots from hemophilie plasma. Blood 1996; 88: 3815-23.
18. Wang W, Hendriks D, Scharpé S. Carboxypeptidase U: a plasma carhoxypeptidase with high affinity for plasminogen. J Biol Chem 1994; 269: 15937-44.
19. Redlitz A, Tan A, Ealon D, Plow E. Plasma carboxypeptidases as regulators of the plasminogen system. J Clin Invest 1995; 96: 2534-8.
20. Wang W, Boffa M, Bajzar L, Walker J, Nesheim M. A study of the mechanism of inhibition of fibrinolysis by activated thrombin-activable fibrinolysis inhibitor. J Biol Chem 1998; 42: 27176-81.
21. Sakharov D, Plow E, Rijken D. On the mechanism of the antifibrinolytic activity of plasma carboxypeptidase B. J Biol Chem 1997; 272: 14477-82.
22. Pannell R. Black J, Gurewich V. Complementary modes of action of tissue-type plasminogen activator and prourokinase by which their synergistic effect on clot lysis may be explained. J Clin Invest 1988; 81: 853-9.
23. Schatteman K, Goossens F. Scharpé S, Neels H, Hendriks D. Assay of procarboxypeptidase U - a novel determinant of the fibrinolytic cascade -in human plasma. Clin Chem 1999; 45: 807-13.
24. Hendriks D, Scharpé S, van Sande M. Assay of carboxypeptidase N activity in serum by liquid-chromatographic determination of hippuric acid. Clin Chem 1985; 31: 1936-9.