Localization of the histamine H2 receptor, a target for antiulcer drugs, in gastric parietal cells

Digestion

Volumn 60, Issue 6, 1999, Pages 522-527

  Fukushima, Yasushi ^a,d   Ohmachi, Yasushi ^c   Asano, Tomoichiro ^a   Nawano, Masao ^a   Funaki, Makoto ^a   Anai, Motonobu ^a   Ogihara, Takehide ^a   Inukai, Kouichi ^a   Onishi, Yukiko ^a   Sakoda, Hideyuki ^a   Saitoh, Toshihito ^b   Matsuhashi, Nobuyuki ^a   Yazaki, Yoshio ^a   Sugano, Kentaro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Antiulcer drugs; Histamine H2 receptor, localization; Immunohistochemistry

Indexed keywords

ANTIULCER AGENT; HISTAMINE H2 RECEPTOR; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; MEMBRANE RECEPTOR; MONOCLONAL ANTIBODY; RECEPTOR ANTIBODY;

ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; DRUG TARGETING; IMMUNOHISTOCHEMISTRY; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RECEPTOR GENE; STOMACH PARIETAL CELL;

EID: 0032700408     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000007701     Document Type: Article

References (12)

1. 2 receptors. Nature 1972;236: 385-390.
2. Soll AH: The actions of secretagogues on oxygen uptake by isolated mammalian parietal cells. J Clin Invest 1978;61:370-380.
3. Soll AH, Wollin A: Histamine and cyclic AMP in isolated canine parietal cells. Am J Physiol 1979;237:E444-E4450.
4. 14C]aminopyrine accumulation by isolated canine parietal cells. Am J Physiol 1980;238:G366-G375.
5. Mezey E, Palkovits M: Localization of targets for anti-ulcer drugs in cells of the immune system. Science 1992;258:1662-1665.
6. 2 receptor and gene transcripts in rat stomach: Back to parietal cells. Biochem Biophys Res Commun 1994;198:1195-1202.
7. 2 receptor. Proc Natl Acad Sci USA 1991;88: 429-433.
8. 2 receptor signaling, desensitization, and agonist-induced internalization. J Biol Chem 1997;272:19464-19470.
9. Inukai K, Funaki M, Ogihara T, Katagiri H, Kanada A, Anai M, Fukushima Y, Hosaka T, Suzuki M, Shin BC, Takata K, Yazaki Y, Kikuchi M, Oka Y, Asano T: p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin. J Biol Chem 1997;272:7873-7882.
10. 2-receptor gene. Biochem Biophys Res Commun 1991;179:1470-1478.
11. 2 receptor by site-directed mutagenesis: N-glycosylation is not vital for its action. Biochem J 1995;310:553-558.
12. 2 receptors expressed in Sf9 and COS7 cells. FEBS Lett 1997;409:283-286.