Antipsychotic medication for challenging behaviour in people with intellectual disability: A systematic review of randomized controlled trials

Journal of Intellectual Disability Research

Volumn 43, Issue 5, 1999, Pages 360-371

  Brylewski, J ^a   Duggan, L ^b  

^a Oxfordshire Lrng Disability NHS T   (United Kingdom)

^b Fair Mile Hospital   (United Kingdom)

Author keywords

Antipsychotic agents; Challenging behaviour; Randomized controlled trials

Indexed keywords

BENZAZEPINE DERIVATIVE; CHLORPROMAZINE; ELTOPRAZINE; NEUROLEPTIC AGENT; PIPAMPERONE; PLACEBO; TREPIPAM MALEATE; UNCLASSIFIED DRUG;

ADULT; AGGRESSION; AGITATION; ARTICLE; BEHAVIOR DISORDER; CLINICAL TRIAL; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DROWSINESS; DRUG EFFICACY; FALLING; FEMALE; GASTROINTESTINAL DISEASE; HUMAN; INFORMATION PROCESSING; INTELLECTUAL IMPAIRMENT; MAJOR CLINICAL STUDY; MALE; MOTOR DYSFUNCTION; RANDOMIZED CONTROLLED TRIAL; SCHIZOPHRENIA; SEIZURE; SIDE EFFECT; SLEEP DISORDER; TREATMENT OUTCOME; VERTIGO;

ANTIPSYCHOTIC AGENTS; CONDUCT DISORDER; HUMANS; MENTAL RETARDATION; RANDOMIZED CONTROLLED TRIALS; TREATMENT OUTCOME;

EID: 0032700378     PISSN: 09642633     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2788.1999.043005360.x     Document Type: Article

References (46)

1. Albert J. M., Elie R., Cooper S. F., Clermont A. & Langlois Y. (1977) Efficacy of SCH-12679 in the management of aggressive mental retardates. Current Therapeutic Research 21, 786-95.
2. Aman M. G. (1984) Drugs and learning in mentally retarded persons. In: Advances in Human Psychopharmacology (eds G. D. Burrows & J. S. Werry), pp. 121-63. JAI Press, Greenwich, CT.
3. Aman M. G., Teehan C. J., White T. J., Turbott S. H. & Vaithianathan C. (1989) Haloperidol treatment with chronically medicated residents: dose effects on clinical behaviour and reinforcement contingencies. American Journal on Mental Retardation 93, 452-60.
4. Bair H. V. & Herold W. (1955) Efficacy of chlorpromazine in hyperactive mentally retarded children. Archives of Neurology and Psychiatry 74, 363-4.
5. British Medical Assocation (BMA) (1997) British National Formulary. British Medical Association and Royal Pharmaceutical Society of Great Britain, London.
6. Capes L., Moore B. C., Capes L. & Moore B. C. (1970) Behaviour differences between seizure and non-seizure retardates. Arizona Medicine 27, 74-6.
7. De Cuyper H., van Praag H. M. & Verstraeten D. (1985) The effect of milenperone on the aggressive behaviour of oligophrenic patients. A double-blind placebo-controlled study. Neuropsychobiology 13, 101-5.
8. Deb S. & Hunter D. (1991) Psychopathology of people with mental and epilepsy, 1: Maladaptive behaviour. British Journal of Psychiatry 159, 822-6.
9. Duggan L. & Brylewski J. (1998) Antipsychotics, learning disability and schizophrenia. In: Schizophrenia Module of the Cochrane Database of Systematic Reviews [updated November 1997] in the Cochrane Library [database on disk and CDROM]: The Cochrane Collaboration, Issue 1 (eds C. E. Adams, L. Duggan, K. Wahlbeck & P. White). Update Software, Oxford. (Updated quarterly.)
10. Elie R., Langlois Y., Cooper S. F., Gravel G. & Albert J.-M. (1980) Comparison of SCH-12679 and thioridazine in aggressive mental retardates. Canadian Journal of Psychiatry 25, 484-91.
11. Emerson C. (1995) Challenging Behaviour. Analysis and Intervention in People with Learning Difficulties. Cambridge University Press, Cambridge.
12. European Rating Aggression Group (ERAG) (1992) Social Dysfunction and Aggression Scale (SDAS-21) in generalized aggression and in aggressive attacks: a validity and reliability study. International Journal of Methods in Psychiatric Research 2, 15-29.
13. Eyman R. K., Moore B. C., Capes L. & Zachofsky T. (1969) Maladaptive behaviour of institutionalized retardates with seizures. American Journal of Mental Deficiency 74, 651-9.
14. Gingell K. & Nadarajah J. (1994) A controlled community study of movement disorder in people with learning difficulties on antipsychotic medication. Journal of Intellectual Disability Research 37, 53-9.
15. Hammock R. G., Schroeder S. R. & Levine W. R. (1995) The effect of clozapine on self-injurious behaviour. Journal of Autism and Developmental Disorders 25, 611-26.
16. Harris P. (1993) The nature and extent of aggressive behaviour amongst people with learning difficulties (mental handicap) in a single health district. Journal of Intellectual Disability Research 37, 221-42.
17. van Hemert J. C. J. (1975) Pipamperone (dipiperon, R3345) in troublesome mental retardates: a double-blind placebo controlled cross-over study with long-term follow-up. Acta Psychiatrica Scandinavica 52, 237-45.
18. Izmeth G. A., Khan S. Y., Kumarajweewa D. I. S. C., Shivanathan S., Veall R. M. & Wiley Y. V. (1988) Zuclopenthixol decanoate in the management of behavioural disorders in mentally handicapped patients. Pharmatherapeutica 5, 217-27.
19. Karsten D., Kivimaki T., Linna S. L., Pollari L. & Turunen S. (1981) Neuroleptic treatment of oligophrenic patients. Acta Psychiatrica Scandinavica Supplementum 294, 39-45.
20. King B. H., De Antonio C., McCracken J. T., Forness S. R. & Ackerland V. (1994) Psychotic consultation in severe and profound mental retardation. American Journal of Psychiatry 151, 1802-8.
21. de Koning P., Mak M., de Vries M. H., Allsopp L. F., Stevens R. B., Verbruggen R., Van den Borre R., van Peteghem P., Kohen D. & Arumainayagam M. (1994) Eltoprazine in aggressive mentally handicapped patients: a double-blind, placebo-and baseline-controlled multi-centre study. The Eltoprazine Aggression Research Group American Journal of Psychiatry 151, 1802-8.
22. Linaker O. M. (1990) Frequency and determinants for psychotropic drug use in an institution for the mentally retarded. British Journal of Psychiatry 156, 525-30.
23. Lindholm O. (1967) A clinical study of esucos in a mentally retarded clientele. International Journal of Neuropsychiatry 3, 209-18.
24. Lynch D. M., Eliatamby C. L. S. & Anderson A. A. (1985) Pipothiazine palmitate in the management of aggressive mentally handicapped patients. British Journal of Psychiatry 146, 525-9.
25. Manchester D. (1993) Neuroleptics, learning disability, and the community: some history and mystery. British Medical Journal 307, 184-7.
26. McKenzie M. E. & Roswell-Harris D. (1966) A controlled trial of Prothipendyl (Tolnate) in mentally subnormal patients. British Journal of Psychiatry 112, 95-100.
27. Millichamp C. J. & Singh N. N. (1987) The effects of intermittent drug therapy on stereotypy and on stereotypy and collateral behaviours of mentally retarded persons. Research in Developmental Disabilities 8, 213-27.
28. Mulrow C. D. & Oxman A. D. (eds) (1996) Cochrane Collaboration Handbook. [Updated 1 March 1997] In: The Cochrane Library [Database on Disk and CDROM]. The Cochrane Collaboration Update Software, Oxford. (Updated quarterly.)
29. Nielsen B. (1967) Oligofrene patienter behandlet med flupentixol. Nordisk Psykiatrisk Tidsskrift 21, 244-53.
30. Oliver C., Murphy G. H. & Corbett J. A. (1987) Self-injurious behaviour in people with mental handicap: a total population study. Journal of Mental Deficiency Research 31, 147-62.
31. Rinck C., Guidry J. & Calkins C. F. (1989) Review of states' practice on the use of psychotropic medication. American Journal of Mental Retardation 93, 657-68.
32. Rogers D., Karki C., Bartlett C. & Pocock P. (1991) The motor disorders of mental handicap. An overlap with the motor disorders of severe psychiatric illness. British Journal of Psychiatry 158, 97-102.
33. Sachdev P. (1992) Drug induced movement disorders in institutionalised adults with mental retardation. Clinical characteristics and risk factors. Australian and New Zealand Journal of Psychiatry 26, 242-8.
34. Schaal D. W. & Hackenburg T. (1994) Toward a functional analysis of drug treatment for behaviour problems of people with developmental disabilities. Mental Retardation 92, 123-40.
35. Schulz K. F., Chalmers I., Grimes D. A. & Altman D. G. (1994) Assembling the quality of randomization from reports of controlled trials published in obstetrics and gynaecology journals. Journal of the American Medical Association 272, 125-8.
36. Sime D. A. & Easby F. P. D. (1974) A double-blind cross-over study of the effect of beclamide (nydrane) on behaviour disorders in the severely mentally handicapped. British Journal of Mental Subnormality 20, 90-2.
37. Singh N. N. & Aman M. G. (1981) Effects of thioridazine dosage on the behaviour of severely mentally retarded persons. American Journal of Mental Deficiency 85, 580-7.
38. Singh I. & Owino W. J. E. (1992) A double-blind comparison of zuclopenthixol tablets with placebo in the treatment of mentally handicapped in-patients with associated behavioural disorders. Journal of Intellectual Disability Research 36, 541-9.
39. Vaisanen K., Rimon R., Raisanen P. & Viukari M. (1979) A controlled double-blind study of haloperidol versus thioridazine in the treatment of restless mentally subnormal patients. Serum levels and clinical effects. Acta Psychiatrica Belgica 79, 673-85.
40. Vanden Borre R., Vermote R., Buttiens M., Thiry P., Dierick G., Geujens J., Sieben G. & Heylen S. (1993) Risperidone as add-on therapy in behavioural disturbances in mental retardation: a double-blind placebo cross-over study. Acta Psychiatrica Scandinavica 87, 167-71.
41. Weir T. W. H., Kernohan G. A. & MacKay D. N. (1968) The use of pericyazine and chlorpromazine with disturbed mentally subnormal patients. British Journal of Psychiatry 114, 111-12.
42. White T. J. R. & Aman M. G. (1985) Pimozide treatment in disruptive severely retarded patients. Australian and New Zealand Journal of Psychiatry 19, 92-4.
43. Youseff H. A. & Waddington J. L. (1988) Involuntary orofacial movements in hospitalised patients with mental handicap or epilepsy; relationship to developmental/ relationship to developmental/ intellectual deficit and presence or absence of long term exposure to neuroleptics. Journal of Neurology, Neurosurgery and Psychiatry 51, 863-5.
44. Yudofsky S. C., Silver J. M., Jackson W., Endicott J. & Williams D. (1986) The Overt Aggression Scale for the objective rating of verbal and physical aggression. American Journal of Psychiatry 143, 33-9.
45. Zimmermann R. L. & Heistad G. T. (1982) Studies of the long term efficacy of antipsychotic drugs in controlling the behaviour of institutionalized retardates. Journal of the American Academy of Child Psychiatry 21, 136-43.
46. Zwanikken G. J. (1973) Penfluridol (R 16341). A long-acting oral neuroleptic, as maintenance therapy for schizophrenic and mentally retarded patients. Psychiatria, Neurologia, Neurochirurgia 76, 83-92.