3-Deazaadenosine prevents adhesion molecule expression and atherosclerotic lesion formation in the aortas of C57BL/6J mice

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 19, Issue 11, 1999, Pages 2673-2679

  Walker, Gerhard ^a   Langheinrich, Alexander C ^a   Dennhauser, Elisabeth ^a   Bohle, Rainer M ^b   Dreyer, Thomas ^b   Kreuzer, Jörg ^b   Tillmanns, Harald ^a   Braun Dullaeus, Ruediger C ^a   Haberbosch, Werner ^a,c  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY HOSPITAL GIESSEN   (Germany)

Author keywords

Adenosine analogues; Atherosclerosis; Cell adhesion molecules; Hypercholesterolemia; Immunohistochemistry

Indexed keywords

3 DEAZAADENOSINE; INTERCELLULAR ADHESION MOLECULE 1; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENIC DIET; ATHEROSCLEROSIS; CHOLESTEROL DIET; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; FEMALE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION;

EID: 0032696981     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.19.11.2673     Document Type: Article

References (40)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-809.
2. Alexander RW. Inflammation and coronary artery disease [editorial; comment]. N Engl J Med. 1994;331:468-469.
3. Entman ML, Ballantyne CM. Inflammation in acute coronary syndromes [editorial; comment]. Circulation. 1993;88:800-803.
4. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 1994;76:301-314.
5. Steinberg D, Witztum JL. Lipoproteins and atherogenesis: current concepts. JAMA. 1990;264:3047-3052.
6. Jang Y, Lincoff AM, Plow EF, Topol EJ. Cell adhesion molecules in coronary artery disease. J Am Coll Cardiol. 1994;24:1591-1601.
7. Poston RN, Haskard DO, Coucher JR, Gall NP, Johnson TR. Expression of intercellular adhesion molecule-1 in atherosclerotic plaques. Am J Pathol. 1992;140:665-673.
8. Cybulsky MI, Gimbrone MA Jr. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science. 1991;251:788-791.
9. Li H, Cybulsky MI, Gimbrone MA Jr, Libby P. An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler Thromb. 1993;13:197-204.
10. Richardson M, Hadcock SJ, DeReske M, Cybulsky MI. Increased expression in vivo of VCAM-1 and E-selectin by the aortic endothelium of normolipemic and hyperlipemic diabetic rabbits. Arterioscler Thromb. 1994;14:760-769.
11. Qiao JH, Xie PZ, Fishbein MC, Kreuzer J, Drake TA, Demer LL, Lusis AJ. Pathology of atheromatous lesions in inbred and genetically engineered mice: genetic determination of arterial calcification. Arterioscler Thromb. 1994;14:1480-1497.
12. van der Wal, Das PK, Tigges AJ, Decker AE. Adhesion molecules on the endothelium and mononuclear cells in human atherosclerotic lesions. Am J Pathol. 1992;141:1427-1433.
13. O'Brien KD, Allen MD, McDonald TO, Chait A, Harlan JM, Fishbein D, McCarty J, Ferguson M, Hudkins K, Benjamin CD, et al. Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques: implications for the mode of progression of advanced coronary atherosclerosis [see comments]. J Clin Invest. 1993;92:945-951.
14. Nageh MF, Sandberg ET, Marotti KR, Lin AH, Melchior EP, Bullard DC, Beaudet AL. Deficiency of inflammatory cell adhesion molecules protects against atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 1997;17:1517-1520.
15. Aksamit RR, Falk W, Cantoni GL. Inhibition of chemotaxis by S-3-deazaadenosylhomocysteine in a mouse macrophage cell line. J Biol Chem. 1982;257:621-625.
16. Aksamit RR, Backlund PS Jr, Cantoni GL. Chemotaxis and the synthesis of specific proteins are inhibited by 3-deazaadenosine and other adenosine analogs in a mouse macrophage cell line. J Biol Chem. 1983;258:20-23.
17. Garcia CI, Mato JM, Vasanthakumar G, Wiesmann WP, Schiffmann E, Chiang PK. Paradoxical effects of adenosine on neutrophil chemotaxis. J Biol Chem. 1983;258:4345-4349.
18. Medzihradsky JL. Regulatory role for the immune complex in modulation of phagocytosis by 3-deazaadenosine. J Immunol. 1984;133:946-949.
19. Pike MC, Snyderman R. Transmethylation reactions regulate affinity and functional activity of chemotactic factor receptors on macrophages. Cell. 1982;28:107-114.
20. Sung SJ, Silverstein SC. Inhibition of macrophage phagocytosis by methylation inhibitors: lack of correlation of protein carboxymethylation and phospholipid methylation with phagocytosis. J Biol Chem. 1985;260:546-554.
21. Zimmerman TP, Iannone M, Wolberg G. 3-Deazaadenosine: S-adenosylhomocysteine hydrolase-independent mechanism of action in mouse lymphocytes. J Biol Chem. 1984;259:1122-1126.
22. Zimmerman TP, Wolberg G, Stopford CR, Prus KL, Iannone MA. Biological Methylation and Drug Design. Clifton, NJ: Humana Press; 1986:417-426.
23. Jurgensen CH, Huber BE, Zimmerman TP, Wolberg G. 3-Deazaadenosine inhibits leukocyte adhesion and ICAM-1 biosynthesis in tumor necrosis factor-stimulated human endothelial cells. J Immunol. 1990;144:653-661.
24. Smith DM, Johnson JA, Turner RA. Biochemical perturbations of BW 91Y (3-deazaadenosine) on human neutrophil chemotactic potential and lipid metabolism. Int J Tissue React. 1991;13:1-18.
25. Flexner CW, Hildreth JE, Kuncl RW, Drachman DB. 3-Deaza-adenosine and inhibition of HIV [letter]. Lancet. 1992;339:438.
26. Paigen B, Morrow A, Holmes PA, Mitchell D, Williams RA. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis. 1987;68:231-240.
27. Kattermann R, Jaworek D, Moller G, Assmann G, Bjorkhem I, Svensson L, Borner K, Boerma G, Leijnse B, Desager JP, et al. Multicentre study of a new enzymatic method of cholesterol determination. J Clin Chem Clin Biochem. 1984;22:245-251.
28. Mehrabian M, Demer LL, Lusis AJ. Differential accumulation of intimal monocyte-macrophages relative to lipoproteins and lipofuscin corresponds to hemodynamic forces on cardiac valves in mice. Arterioscler Thromb. 1991;11:947-957.
29. Paigen B, Ishida BY, Verstuyft J, Winters RB, Albee D. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis. 1990;10:316-323.
30. Lin AH, Castle CK, Melchior GW, Marotti KR. The effect of population density on the development of experimental atherosclerosis in female mice. Atherosclerosis. 1995;115:85-88.
31. Gerrity RG. The role of the monocyte in atherogenesis, II: migration of foam cells from atherosclerotic lesions. Am J Pathol. 1981;103:191-200.
32. Munro JM, Cotran RS. The pathogenesis of atherosclerosis: atherogenesis and inflammation. Lab Invest. 1988;58:249-261.
33. Ross R, Fuster V. Traffic signals on endothelium for leukocytes in health, inflammation and atherosclerosis. In: Fuster V, Ross R, Topol E, eds. Atherosclerosis and Coronary Artery Disease. Philadelphia, Pa: Lippincott-Raven Publishers; 1996:511-537.
34. Patel SS, Thiagarajan R, Willerson JT, Yeh ET. Inhibition of α4 integrin and ICAM-1 markedly attenuate macrophage homing to atherosclerotic plaques in ApoE-deficient mice. Circulation. 1998;97:75-81.
35. Davies MJ, Gordon JL, Gearing AJ, Pigott R, Woolf N, Katz D, Kyriakopoulos A. The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis. J Pathol. 1993;171:223-229.
36. Ridker PM, Hennekens CH, Roitman JB, Stampfer MJ, Allen J. Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men. Lancet. 1998;351:88-92.
37. Shankar R, de la Motte CA, DiCorleto PE. 3-Deazaadenosine inhibits thrombin-stimulated platelet-derived growth factor production and endothelial-leukocyte adhesion molecule-1-mediated monocytic cell adhesion in human aortic endothelial cells. J Biol Chem. 1992;267:9376-9382.
38. Leonard EJ, Skeel A, Chiang PK, Cantoni GL. The action of the adenosylhomocysteine hydrolase inhibitor, 3-deazaadenosine, on phagocytic function of mouse macrophages and human monocytes. Biochem Biophys Res Commun. 1978;84:102-109.
39. Jeong SY, Lee JH, Kim HS, Hong SH, Cheong CH, Kim IK. 3-Deazaadenosine analogues inhibit the production of tumour necrosis factor-α in RAW264.7 cells stimulated with lipopolysaccharide. Immunology. 1996;89:558-562.
40. Endresen PC, Loennechen T, Kildalsen H, Aarbakke J. Apoptosis and transmethylation metabolites in HL-60 cells. J Pharmacol Exp Ther. 1996;278:1318-1324.