Effects of NO synthase inhibitors on the synovial microcirculation in the mouse knee joint

Journal of Vascular Research

Volumn 36, Issue 5, 1999, Pages 379-384

  Veihelmann, Andreas ^a   Krombach, F ^b   Refior, H J ^b   Messmer, K ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b NONE

Author keywords

Arthritis; Knee joint; L NAME; L NIL; Mouse; Nitric oxide; Synovial microcirculation

Indexed keywords

LYSINE DERIVATIVE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIOLE; ARTHRITIS; ARTICLE; BLOOD FLOW VELOCITY; CAPILLARY DENSITY; CELL INTERACTION; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME INHIBITION; ERYTHROCYTE; FEMALE; FLUORESCENCE MICROSCOPY; INTRAVENOUS DRUG ADMINISTRATION; KNEE; LEUKOCYTE; MICROCIRCULATION; MOUSE; NONHUMAN; PATELLA TENDON; PRIORITY JOURNAL; SYNOVIUM; VENULE;

ANIMALS; ARTERIOLES; CELL ADHESION; ENZYME INHIBITORS; FEMALE; KNEE JOINT; LEUKOCYTES; LYSINE; MICE; MICE, INBRED BALB C; MICROCIRCULATION; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; SYNOVIAL MEMBRANE; VASOCONSTRICTOR AGENTS;

EID: 0032696138     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000025677     Document Type: Article

References (27)

1. Stadler J, Stefanovic-Racic, Billiar RD, Curran RD, McIntyre LA, Georgescu HI, Simmons RL, Evans CH; Articular chondrocytes synthetize nitric oxide in response to cytokines and lipopolysaccharide. J Immunol 1991;147: 3915-3921.
2. Stefanovic-Racic M, Stadler J, Evans CH: Nitric oxide and arthritis. Arthritis Rheum 1993; 36:1036-1044.
3. Cannon GW, Openshaw SJ, Hibbs JB, Hoidal JR, Hueckstaedl TP, Griffiths MM: Nitric oxide production during adjuvant-induced and collagen-induced arthritis. Arthritis Rheum 1996;39:1677-1684.
4. Grabowski PS, Wright PK, Van't Hof RJ, Helfrich MH, Oshshima H, Ralston SH: Immunolocalization of inducible nitric oxide synthase in synovium and cartilage in rheumatoid arthritis and osteoarthritis. Br J Rheumatol 1997;36:651-655.
5. Hilliquin P, Borderie D, Hernvann A, Menkes CJ, Ekindjian OG: Nitric oxide as S-nitrosoproteins in rheumatoid arthritis. Arthritis Rheum 1997;40:1512-1517.
6. Evans CH, Stefanovic-Racic M, Lancaster J: Nitric oxide and its role in orthopaedic disease. Clin Orthop 1995;312:275-294.
7. Veihelmann A, Brill T, Blobner M, Scheller I, Mayer B, Stadler J: Inhibition of nitric oxide improves detoxification in inflammatory liver dysfunction in vivo. Am J Physiol 1997;36: G530-G537.
8. McCartney-Francis N, Allen JB, Mizel DE, Albina JE, Xie Q, Nathan CF: Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med 1993;178:749-754.
9. Fletcher DS, Widmer WR, Luell S, Christen A, Orevillo C, Shah S, Visco D: Therapeutic administration of a selective inhibitor of nitric oxide synthase does not ameliorate the chronic inflammation and tissue damage associated with adjuvant-induced arthritis in rats. J Pharmacol Exp Ther 1998;284:714-721.
10. Stefanovic-Racic M, Meyers K, Meschter C, Coffey JW, Hoffman RA, Evans CH: Comparison of the nitric oxide synthase inhibitors methylarginine and aminoguanidine as prophylactic and therapeutic agents in rat adjuvant arthritis. J Rheumatol 1995;22:1922-1928.
11. Harris NR: Opposing effects of L-NAME on capillary filtration rate in the presence or absence of neutrophils. Am J Physiol 1997;273: G1320-G1325.
12. Baldwin AL, Thurston G, al Naemi H: Inhibition of nitrix oxide synthesis increases venular permeability and alters endothelial actin cytoskeleton. Am J Physiol 1998;274:H1176-H1784.
13. Davenpeck KL, GauthierTW, Lefer AM: Inhibition of endothelial-derived nitric oxide promotes P-selectin expression and actions in the rat microcirculation. Gastroenterology 1994; 107:1050-1058.
14. Kurose I, Kubes P, Wolf R, Anderson DC, Paulson J, Miyasaka M, Granger DN: Inhibition of nitric oxide production. Circ Res 1993; 73:164-171.
15. 2+]i and microvessel permeability. Am J Physiol 1997; 272:H176-H185.
16. Rumbaut RE, McKay MK, Huxley VH: Capillary hydraulic conductivity is decreased by nitric oxide synthase inhibition. Am J Physiol 1995;268:H1856-H1861.
17. Hickey MJ, Sharkey KA, Sihota EG, Reinhardt PH, MacMicking JD, Nathan C, Kubes P: Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia. FASEB J 1997;11:955-964.
18. McCafferty D-M, Mudgett JS, Swain MG, Kubes P: Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation. Gastroenterology 1997;112:1022-1027.
19. Stenger S, Thuring H, Rollinghoff M, Manning P, Bogdan C: L-N6-(1-iminoethyl)-lysine potently inhibits inducible nitric oxide synthase and is superior to NG-monomethyl-arginine in vitro and in vivo. Eur J Pharmacol 1995;294: 703-712.
20. Veihelmann A, Szczesny G, Nolte D, Krombach, F, Refior HJ, Messmer K: A novel model for the study of synovial microcirculation in the mouse knee joint in vivo. Res Exp Med 1998;198:43-54.
21. Harris AG, Hecht R, Peer F, Nolte D, Messmer K: An improved intravital microscopy system. Int J Microcirc 1997;17:322-327.
22. Zeintl H, Sack F-U, Intaglietta M, Messmer K: Computer assisted leukocyte velocity measurements in intravital microscopy. Int J Microcirc 1989;8:293-302.
23. Kubes P, Kurose I, Granger DN: NO donors prevent integrin-induced leukocyte adhesion but not P-selectin-dependent rolling in postischemic venules. Am J Physiol 1994;267: H931-H937.
24. Mitchell DJ, Yu J, Tyml K: Local L-NAME decreases blood flow and increases leukocyte adhesion via CD18. Am J Physiol 1998;274: H1264-H1268.
25. Spiecker M, Peng HB, Liao JK: Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IkappaBalpha. J Biol Chem 1997;272:30969-30974.
26. Spiecker M, Darius H, Kaboth K, Hubner F, Liao JK: Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants. J Leukoc Biol 1998;63:732-739.
27. Najafipour H, Ferrell WR: Nitric oxide modulates sympathetic vasoconstriction and basal blood flow in normal and acutely inflamed rabbit knee joints. Exp Physiol 1993;78:615-624.