Effect of maternal anticonvulsant treatment on neonatal blood coagulation

Archives of Disease in Childhood: Fetal and Neonatal Edition

Volumn 81, Issue 3, 1999, Pages

  Hey, Edmund ^a   Hey, E ^a  

^a ROYAL VICTORIA INFIRMARY   (United Kingdom)

Author keywords

Anticonvulsant medication in pregnancy; Early vitamin K deficiency bleeding; Prothrombin deficiency

Indexed keywords

CARBAMAZEPINE; PHENOBARBITAL; PHENYTOIN; PHYTOMENADIONE;

ANTICONVULSANT ACTIVITY; ARTICLE; BLEEDING; BLOOD CLOTTING; BLOOD SAMPLING; CLINICAL ARTICLE; CONVULSION; EARLY DIAGNOSIS; FEMALE; HUMAN; MALE; NEWBORN; PRIORITY JOURNAL; PROTHROMBIN DEFICIENCY; PROTHROMBIN TIME; TREATMENT PLANNING; VITAMIN K DEFICIENCY;

EID: 0032695257     PISSN: 13592998     EISSN: 14682052     Source Type: Journal    
DOI: 10.1136/fn.81.3.F208     Document Type: Article

References (28)

1. van Creveld S. Nouveaux aspects de la maladie hémorragique du nouveau-né. Arch Fr Pediatr 1958;15:721-35.
2. Mountain KR, Hirsh J, Gallus AS. Neonatal coagulation defect due to anticonvulsant drug treatment in pregnancy. Lancet 1970;i:265-8.
3. Cornelissen M, Steegers-Theunissen R, Kollée L, et al. Increased incidence of neonatal vitamin K deficiency resulting from maternal anticonvulsant exposure. Am J Obsta Gynecol 1993;168:923-7.
4. Astedt B. Antenatal drugs affecting the vitamin K status of the fetus and the newborn. In: Sutor AH, Hathaway WE, eds. Vitamin K in Infancy. Stuttgart: Schattauer, 1995: 85-91.
5. Douglas H. Haemorrhage in the newborn. Lancet 1966;i:816-7.
6. Alagille D, Odievre M, Houllemare L, Viterbo G, Lerpy D. Avitaminose K neonatale severe chez 2 enfants nés de mère traitée par des anticomitiaux. Arch Fr Pediatr 1968;25:31-11.
7. Monnet P, Rosenberg D, Bovier-Lapierre M. Thérapeutique anticomitiale administrée pendant la grossese et maladie hémorragique du nouveau-né. Remarques critiques àpropos de trois observations personnelles. Rev Fr Gynecol Obstet 1968;63:695-702.
8. Margolin FG, Kantor NM. Hemorrhagic disease of the newborn. An unusual case related to maternal ingestion of an anti-epileptic drug. Clin Fed 1972;11:59-60.
9. Waltl H, Mitterstieler G, Schwingshackl A. Hämorrhagische diasthese bei einen neugeborenen einer mutter mit antiepilischer thérapie. Dach Med VC'ochenschr 1974;99:1315-7.
10. Bleyer VA, Skinner AL. Fatal neonatal hemorrhage after maternal anticonvulsant therapy. JA AIA 1976;235:625-7.
11. Griffiths AD. Neonatal haemorrhage associated with maternal anticonvulsant therapy. Lancet 1981;ii:1296-7.
12. Srinivasan G, Seeler RA, Tiruvury A, Pildes RS. Maternal anticonvulsant therapy and hemorrhagic disease of the newborn. Obstet Gynecol 1982:59:250-2.
13. McNinch AV, Orme R L-E, Tripp JH. Haemorrhagic disease of the newborn returns. Lancet 1983;i: 1089-90.
14. Tripp J, Cornelissen M, Loughnan P, McNinch A, Schubiger G, von Kries R. Suggested protocol for the reporting of prospective studies of vitamin K deficiency bleeding (previously called hemorrhagic disease of the newborn). In: Sutor AH, Hathaway WE, eds. Vitamin Kin infamy. Stuttgart: Schattauer, 1995:395-401.
15. Speidel BD, Meadow SR. Maternal epilepsy and abnormalities of the fetus and newborn. Lancet 1972;ii:839-43.
16. Lane PA, Hathaway WE. Vitamin K in infancy. J Pediatr 1985;106;351-9.
17. Sutor AH. Vitamin K deficiency bleeding in infancy: a status report. In: Sutor AH, Hathaway WE, eds. Vitamin K in Infancy. Stuttgart: Schattauer, 1995: 3-18.
18. Salomonsen L. Morbus hemorrhagicus neonatorum. (Hypoprothrombinemia neonatorum). Acta Paediatr Scand 1939;27(suppll):l-120.
19. Lehman, J. Vitamin K as a prophylactic in 13,000 infants. Lancet 1944;1:493-1.
20. Anonymous. Haemorrhage in the newborn. [Editorial], Lancet 1944;i:506-8.
21. Lehmann J. Vitamin K as a prophylactic. Lancet 1944;ii:737-8.
22. Deblay MF, Vert P, André M, Marchai F. Transplacental vitamin K prevents haemorrhagic disease of infants of epileptic mothers. Lancet 1982;i:1247.
23. Cornelissen M, Steegers-Theunissen R, Kollée L, Eskes T, Motohara K, Monnens L. Supplementation of vitamin K in pregnant women receiving anticonvulsant therapy prevents neonatal vitamin K deficiency. Am J Obstet Gynea 1993;168:884-8.
24. Kazzi NJ, Ilagan NB, Liang K-C, àal. Maternal administration of vitamin K does not improve the coagulation profile of prêterai infants. Pediatrics 1989;S4:104550.
25. Thorp JA, Parriot J, Ferrette-Smith D, Meyer BA, Cohen GR, Johnson J. Antepartum vitamin K and phénobarbital for preventing intraventicular hemorrhage in the premature infant: 'a randomised, double-blind, placebocontrolled study. Obstet Gynecol 1994;83:70-6.
26. Wallace H, Shorvon SD, Hopkins A, O'Donoghue M. Adults Kith poorly controlled epilepsy. London: Royal College of Physicians, 1997.
27. Passmore SJ, Draper G, Brownbill P, Kroll M. Case-control studies of relation between childhood cancer and neonatal vitamin K administration. BMJ 1998;316:178-84.
28. Tripp JH, McNinch AW. The vitamin K debacle: cut the Gordian knot but first do no harm. Arch Dis Child 1998;79:295-7.