메뉴 건너뛰기




Volumn 29, Issue 11, 1999, Pages 1089-1100

In vitro metabolism of mifepristone (RU-486) in rat, monkey and human hepatic S9 fractions: Identification of three new mifepristone metabolites

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGESTAGEN; DRUG METABOLITE; FORMYLMIFEPRISTONE; HYDROXYMETHYLMIFEPRISTONE; MIFEPRISTONE; N DESMETHYLMIFEPRISTONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

EID: 0032695229     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/004982599237976     Document Type: Article
Times cited : (14)

References (13)
  • 1
    • 0027394348 scopus 로고
    • Mifepristone: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential
    • BROGDEN, R. N., GOA, K. L. and FAULDS, D., 1993, Mifepristone: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential. Drugs, 45, 384-409.
    • (1993) Drugs , vol.45 , pp. 384-409
    • Brogden, R.N.1    Goa, K.L.2    Faulds, D.3
  • 2
    • 0027369690 scopus 로고
    • Biotransformation of 17β-hydroxy-11β-(4-dimethylaminophenyl)17α-1-propynyl-estra-4,9- dien-3-one (RU486) in rat hepatoma variants
    • CHASSEROT-GOLAZ, S., BECK, G. and VENETIANER, A., 1993, Biotransformation of 17β-hydroxy-11β-(4-dimethylaminophenyl)17α-1-propynyl-estra-4,9- dien-3-one (RU486) in rat hepatoma variants. Biochemical Pharmacology, 46, 2100-2103.
    • (1993) Biochemical Pharmacology , vol.46 , pp. 2100-2103
    • Chasserot-Golaz, S.1    Beck, G.2    Venetianer, A.3
  • 4
    • 0030199710 scopus 로고    scopus 로고
    • Determination of RU486 (mifepristone) in blood by radioreceptorassay: A pharmacokinetic study
    • FOLDESI, I., FALKAY, G. and KOVACS, L., 1996, Determination of RU486 (mifepristone) in blood by radioreceptorassay: a pharmacokinetic study. Contraception, 54, 27-32.
    • (1996) Contraception , vol.54 , pp. 27-32
    • Foldesi, I.1    Falkay, G.2    Kovacs, L.3
  • 5
    • 0000161879 scopus 로고
    • Pharmacokinetics of mifepristone (RU486) and its metabolites in pregnant women
    • HE, C., ZHANG, G., BAI, X., JIANG, N., ZHOU, W., GUI, Y., FAN, Q. and CHEN, J., 1994, Pharmacokinetics of mifepristone (RU486) and its metabolites in pregnant women. Shengzhi Yu Biyun, 14, 280-286.
    • (1994) Shengzhi Yu Biyun , vol.14 , pp. 280-286
    • He, C.1    Zhang, G.2    Bai, X.3    Jiang, N.4    Zhou, W.5    Gui, Y.6    Fan, Q.7    Chen, J.8
  • 8
    • 0030582402 scopus 로고    scopus 로고
    • Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes
    • JANG, G. R., WRIGHTON, S. A. and BENET, L. Z., 1996, Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes. Biochemical Pharmacology, 52, 753-761.
    • (1996) Biochemical Pharmacology , vol.52 , pp. 753-761
    • Jang, G.R.1    Wrighton, S.A.2    Benet, L.Z.3
  • 10
    • 0026148814 scopus 로고
    • Automated direct assay system for RU38486, an antiprogesterone-anti-glucocorticoid agent, and its metabolites using high performance liquid chromatography
    • NAGOSHI, K., HAYASHI, N. and SEKIBA, K., 1991, Automated direct assay system for RU38486, an antiprogesterone-anti-glucocorticoid agent, and its metabolites using high performance liquid chromatography. Acta Medica Okayama, 45, 81-87.
    • (1991) Acta Medica Okayama , vol.45 , pp. 81-87
    • Nagoshi, K.1    Hayashi, N.2    Sekiba, K.3
  • 11
    • 0027296437 scopus 로고
    • Pharmacokinetic study of RU 486 and its metabolites after oral administration of single doses to pregnant and non-pregnant women
    • SHI, Y., YE, Z., HE, C., ZHANG, G., XU, J., VAN, L. and FORTHERBY, K., 1993, pharmacokinetic study of RU 486 and its metabolites after oral administration of single doses to pregnant and non-pregnant women. Contraception, 48, 133-149.
    • (1993) Contraception , vol.48 , pp. 133-149
    • Shi, Y.1    Ye, Z.2    He, C.3    Zhang, G.4    Xu, J.5    Van, L.6    Fortherby, K.7
  • 13
    • 85038133721 scopus 로고    scopus 로고
    • Identification of three new mifepristone (RU-486) metabolites in rat, monkey, and human hepatic S9 fractions
    • (abstract, The 8th North American ISSX Meeting)
    • WU, W. N., MCKOWN, L. A. and TAKACS, A. R., 1997, Identification of three new mifepristone (RU-486) metabolites in rat, monkey, and human hepatic S9 fractions. In ISSX Proceedings, 45 (abstract, The 8th North American ISSX Meeting).
    • (1997) ISSX Proceedings , pp. 45
    • Wu, W.N.1    McKown, L.A.2    Takacs, A.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.