Regulation of aquaporin-2 expression by the α2-adrenoceptor agonist clonidine in the rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 291, Issue 2, 1999, Pages 920-923

  Junaid, Asad ^a,b,c   Cui, Li ^b   Penner, S Brian ^a   Smyth, Donald D ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c ST BONIFACE GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; AQUAPORIN; CLONIDINE; VASOPRESSIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIURESIS; FREE WATER CLEARANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; RAT; REGULATORY MECHANISM; TISSUE DISTRIBUTION; URINE FLOW RATE; WATER ABSORPTION;

ADRENERGIC ALPHA-AGONISTS; ANESTHESIA; ANIMALS; AQUAPORIN 2; AQUAPORIN 6; AQUAPORINS; BLOTTING, WESTERN; CLONIDINE; CYTOSOL; DIURESIS; FLUORESCENT ANTIBODY TECHNIQUE; HYBRIDIZATION, GENETIC; KIDNEY MEDULLA; MALE; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; VASOPRESSINS; WATER;

EID: 0032694262     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Apostol E, Ecelbarger C, Terris J, Bradford AD, Andrews P and Knepper M (1997) Reduced renal medullar water channel expression in puromycin aminonucleoside-induced nephrotic syndrome. J Am Soc Nephrol 8:15-24.
2. Blandford DE and Smyth DD (1990) Role of vasopressin in response to intrarenal infusions of alpha-2 adrenoceptor agonists. J Pharmacol Exp Ther 255:264-270.
3. Brooks DP, Edwards RM, Depalma PD, Fredrickson TA, Hieble JP and Gellai M (1991) The water diuretic effect of alpha-2 adrenoceptor agonist, AGN 190851, is species dependent. J Pharmacol Exp Ther 259:1277-1282.
4. Chabardes D, Montegut M, Imbert-Teoboul M and Morel F (1984) Inhibition of alpha 2-adrenergic agonists on AVP-induced cAMP accumulation in isolated collecting tubule of the rat kidney. Mol Cell Endocrinol 37:263-275.
5. Chomczynski P and Sacchi P (1987) Single step method of RNA isolation by acid guanadinium thiocynate-phenol-chloroform extraction. Anal Biochem 162:156-159.
6. Deen PM, Rijss JP, Mulders SM, Errington RJ, van Baal J and van Os CH (1997) Aquaporin-2 transfection of Marby canine kidney cells reconstitutes vasopressin regulated transcellular osmotic water transport. J Am Soc Nephrol 8:1493-1501.
7. Deen PM, Verdijk MA, Knoers NV, Wieringa B, Monnens LA, van Os CH and van Oost BA (1994) Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine. Science 264:92-95.
8. Edwards RM, Stack EJ, Gellai, M and Brooks DP (1992) Inhibition of vasopressin sensitive cAMP accumulation by alpha2-adrenoceptor agonists in collecting tubules is species dependent. Pharmacology 44:26-32.
9. Frokiaer J, Marples D, Knepper M and Nielsen S (1996) Bilateral ureteral obstruction downregulates expression of vasopressin-sensitive AQP-2 water channel in the rat kidney. Am J Physiol 270:F657-F668.
10. Fushimi K, Uchida S, Hara Y, Hirata Y, Marumo F and Sasaki S (1993) Cloning and expression of apical membrane water channel of rat kidney collecting tubule. Nature 361:549-552.
11. Gellai M (1990) Modulation of vasopressin antidiuretic action by renal α2-adrenoceptors. Am J Physiol 259:F1-F8.
12. Gellai M and Ruffolo RR (1987) Renal effects of selective alpha 1- and alpha 2-adrenoceptor agonists in conscious normotensive rats. J Pharmacol Exp Ther 240: 723-728.
13. Hozawa S, Holtzman EJ and Ausiello DA (1996) cAMP motifs regulating transcription in the aquaporin 2 gene. Am J Physiol 270:C1695-C1702.
14. Knepper M (1997) Molecular physiology of urinary concentrating mechanism: Regulation of aquaporin water channels by vasopressin. Am J Physiol 272:F3-F12.
15. Krothapalli RK and Suki WN (1984) Functional characterization of the α-adrenergic receptor modulating the hydroosmotic effect of vasopressin on the rabbit cortical collecting tubule. J Clin Invest 73:740-749.
16. Leander JD, Zerbe RL and Hart JC (1985) Diuresis and suppression of vasopressin by kappa opioids: Comparison with mu and delta opioids and clonidine. J Pharmacol Exp Ther 234:463-469.
17. Marples D, Frokiaer J, Dorup J, Knepper M and Nielsen S (1996) Hypokalemia induced down regulation of aquaporin-2 water channel expression in rat kidney medulla and cortex. J Clin Invest 97:1960-1968.
18. Marples DS, Christensen EI, Christensen PD, Ottosen PD and Nielsen S (1995) Lithium-induced down regulation of aquaporin-2 water channel expression in rat kidney medulla. J Clin Invest 95:1838-1845.
19. Matsumura Y, Uchida S, Rai T, Sasaki S and Marumo F (1997) Transcriptional regulation of aquaporin 2 water channel gene by cAMP. J Am Soc Nephrol 8:861-867.
20. Nielsen S, Terris J, Andersen D, Ecelbarger C, Frokiaer J, Jonassen T, Marples D, Knepper MA and Petersen JS (1997) Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct. Proc Natl Acad Sci USA 94:5450-5455.
21. Pettinger WA, Umemura S, Smyth DD and Jeffries WB (1987) Renal α2-adrenoceptors and the adenylate cyclase-cAMP system: Biochemical and physiological interactions. Am J Physiol 252:F199-F208.
22. Sands JM, Naruse M, Jacobs JD, Wilcox JN and Klein JD (1996) Changes in aquaporin-2 protein contribute to the urine concentrating defect in rats fed a low-protein diet. J Clin Invest 97:2807-2814.
23. Smyth DD, Umemura S and Pettinger WA (1985) Alpha 2-adrenoceptor antagonism of vasopressin-induced changes in sodium excretion. Am J Physiol 248:F767-F772.
24. Stanton B, Puglisi E and Gellai M (1987) Localization of α2-adrenoceptor mediated increase in renal sodium, potassium and water excretion. Am J Physiol 252: F1016-F1021.
25. Strandhoy JW, Morris M and Buckalew V (1982) Renal effects of the antihypertensive guanabenz in the dog. J Pharmacol Exp Ther 221:347-352.
26. Umemura S, Marver D, Smyth DD and Pettinger WA (1985) α2-adrenoceptors and cellular cAMP levels in single nephron segments from the rat. Am J Physiol 249:F28-F33.
27. Xu DL, Martin PY, Ohara M, St. John J, Pattison T, Meng X, Morris K, Kim JK and Schrier RW (1997) Upregulation of aquaporin-2 water channel expression in chronic heart failure. J Clin Invest 99:1500-1505.
28. Yasui M, Zelenin SM, Celsi G and Aperia A (1997) Adenylate cyclase-coupled vasopressin receptor activates aquaporin-2 promoter via a dual effect on CRE and AP1 elements. Am J Physiol 272:F443-F450.