The role of plasma semicarbazide-sensitive amine oxidase in allylamine and β-aminopropionitrile cardiovascular toxicity: Mechanisms of myocardial protection and aortic medial injury in rats

Toxicology

Volumn 138, Issue 3, 1999, Pages 137-154

  Conklin, D J ^a   Trent, M B ^b   Boor, P J ^b  

^a UNIVERSITY OF WISCONSIN EAU CLAIRE   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Aminopropionitrile; Allylamine; Aorta; Heart; Lathyrism; Lysyl oxidase; Medial injury; Rat; Semicarbazide sensitive amine oxidase; Vascular toxicity

Indexed keywords

3 AMINOPROPIONITRILE; ALLYLAMINE; AMINE OXIDASE (FLAVIN CONTAINING); NORADRENALIN; POTASSIUM CHLORIDE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CARBON DIOXIDE BLOOD LEVEL; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; HEART PROTECTION; HEMATOCRIT; IN VITRO STUDY; MALE; METABOLIC CAPACITY; MUSCLE FIBER CULTURE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; UREA NITROGEN BLOOD LEVEL; URINE OSMOLALITY; URINE VOLUME; VASOCONSTRICTION;

ALLYLAMINE; AMINE OXIDASE (COPPER-CONTAINING); AMINOPROPIONITRILE; ANIMALS; AORTA; CARDIOVASCULAR DISEASES; CELL SURVIVAL; CELLS, CULTURED; DRINKING; ENZYME INHIBITORS; HEMODYNAMIC PROCESSES; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032693776     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(99)00095-5     Document Type: Article

References (36)

1. Awasthi S., Boor P.J. Semicarbazide protection from in vivo oxidant injury of vascular tissue by allylamine. Toxicol. Lett. 66:1993;157-163.
2. Biagini R.E., Toraason M.A., Lynch D.W., Winston G.W. Inhibition of rat heart mitochondrial electron transport in vitro: implications for the cardiotoxic action of allylamine or its primary metabolite, acrolein. Toxicology. 62:1990;95-106.
3. Boomsma F., Derkx F.H., van den Meiracker A.H., Man in't Veld A.J., Schalekamp M.A. Plasma semicarbazide-sensitive amine oxidase activity is elevated in diabetes mellitus and correlates with glycosylated haemoglobin. Clin. Sci. 88(6):1995;675-679.
4. Boomsma F., van Veldhuisen D.J., de Kam P.J., Man in't Veld A.J., Mosterd A., Lie K.I., Schalekamp M.A. Plasma semicarbazide-sensitive amine oxidase activity is elevated in patients with congestive heart failure. Cardiovasc. Res. 33:1997;387-391.
5. Boor P.J., Nelson T.J. Allylamine cardiotoxicity: III. Protection by semicarbazide and in vivo derangements of monoamine oxidase. Toxicology. 18:1980;87-102.
6. Boor P.J., Hysmith R.M. Allylamine cardiovascular toxicity: a review. Toxicology. 44:1987;129-144.
7. Boor P.J., Moslen M.T., Reynolds E.S. Allylamine cardiotoxicity: I. Sequence of pathologic events. Toxicol. Appl. Pharmacol. 50:1979;581-592.
8. Boor P.J., Langford S.D. Pathogenesis of medial lesions caused by chemical agents. Sipes I.G., McQueen C.A., Gandolfi A.J. Cardiovascular Toxicology. Comprehensive Toxicology. 6:1998;309-332 Elsevier Science, Amsterdam.
9. Chrvapil M., Misiorowski R., Eskelson C. On the mechanisms of β-aminopropionitrile toxicity. J. Surg. Res. 31:1981;151-155.
10. Conklin D.J., Boor P.J. Allylamine cardiovascular toxicity: evidence for aberrant vasoreactivity in rats. Toxicol. Appl. Pharmacol. 148:1998;245-251.
11. Conklin D.J., Langford S.D., Boor P.J. Contribution of serum and cellular semicarbazide-sensitive amine oxidase to amine metabolism and cardiovascular toxicity. Toxicol. Sci. 46:1998;386-392.
12. Egle J.L., Hudgins P.M. Dose-dependent sympathomimetic and cardioinhibitory effects of acrolein and formaldehyde in the anesthetized rat. Toxicol. Appl. Pharmacol. 28:1974;358-366.
13. Fleisher J.H., Speer D., Brendel K., Chvapil M. Effect of pargyline on the metabolism of β-aminopropionitrile (βAPN) by rabbits. Toxicol. Appl. Pharmacol. 47:1979;61-69.
14. Hayes B.E., Clarke D.E. Semicarbazide-sensitive amine oxidase activity in streptozotocin diabetic rats. Res. Commun. Chem. Pathol. Pharmacol. 69(1):1990;71-83.
15. Hysmith R.M., Boor P.J. Role of benzylamine oxidase in the cytotoxicity of allylamine toward aortic smooth muscle cells. Toxicology. 51:1988;133-145.
16. Jones P.A., Scott-Burden T., Gevers W. Glycoprotein, elastin, and collagen secretion by rat smooth muscle cells. Proc. Natl. Acad. Sci. USA. 76(1):1969;353-357.
17. Kumar D., Hysmith R.M., Boor P.J. Allylamine and β-aminopropionitrile-induced vascular injury: an in vivo and in vitro study. Toxicol. Appl. Pharmacol. 103:1990;288-302.
18. Kumar D., Boor P.J., Trent M.B. Allylamine (AA) and β-aminopropionitrile (βAPN) induced aortic medial necrosis: Possible mechanism of synergism. Toxicology. 125:1998;107-115.
19. Lalich J.J., Paik W.C.W. Influence of hydralazine consumption on allylamine induced myocardial fibrosis and hypertrophy in rats. Exp. Mol. Pathol. 21:1974;29-39.
20. Lewinsohn R., -Heinrich Bohm K., Glover V., Sandler M. A benzylamine oxidase distinct from monoamine oxidase B - widespread distribution in man and rat. Biochem. Pharmacol. 27:1978;1857-1863.
21. Lizcano J.M., Fernandez de Arriba A., Tipton K.F., Unzeta M. Inhibition of bovine lung semicarbazide-sensitive amine oxidase (SSAO) by some hydrazine derivatives. Biochem. Pharmacol. 52:1996;187-195.
22. Lyles G.A., McDougall S.A. The enhanced daily excretion of urinary methylamine in rats treated with semicarbazide or hydralazine may be related to the inhibition of semicarbazide-sensitive amine oxidase activities. J. Pharm. Pharmacol. 41:1989;97-100.
23. Lyles G.A., Garcia-Rodriguez J., Callingham B.A. Inhibitory actions of hydralazine upon monoamine oxidizing enzymes in the rat. Biochem. Pharmacol. 32(17):1983;2515-2521.
24. Mellon R.R., Baker M.R., McIlroy A.P. Experimental necrotizing arteriolitis induced by a protein-cleavage product. Proc. Exp. Biol. Med. 33:1935;192-195.
25. Misra P., Srivastava S.K., Singhal S.S., Awasthi S., Awasthi Y.C., Boor P.J. Glutathione S-transferase 8-8 is localized in smooth muscle cells of rat aorta and is induced in an experimental model of atherosclerosis. Toxicol. Appl. Pharmacol. 133:1995;27-33.
26. Ramos K.S., Grossman S.L., Cox L.R. Allylamine-induced vascular toxicity in vitro: Prevention by semicarbazide-sensitive amine oxidase inhibitors. Toxicol. Appl. Pharmacol. 95:1988;61-71.
27. Simpson C.F. Coronary and thyroid arteriopathy induced by allylamine and β-aminopropionitrile. Exp. Mol. Pathol. 37:1982;382-392.
28. Simpson C.F., Kling J.M., Palmer R.F. The use of propranolol for the protection of turkeys from the development of β-aminopropionitrile-induced aortic ruptures. Angiology. 19:1968;414-418.
29. Tang S.S., Trackman P.C., Kagan H.M. Reaction of aortic lysyl oxidase with β-aminopropionitrile. J. Biol. Chem. 258(7):1983;4331-4338.
30. Trent M.B., Boor P.J. Vascular amine oxidase activities during synergistic vasculotoxicity. Toxicology. 89:1994;67-77.
31. Waters L.L. Changes in the coronary arteries of the dog following injections of allylamine. Am. Heart J. 35:1948;212-220.
32. Will, J.A., 1967. Allylamine induced cardiovascular changes in calves. PhD thesis, University of Wisconsin, WI.
33. Wilmarth K.R., Froines J.R. Role of monoamine oxidase in aminopropionitrile-induced neurotoxicity. J. Toxic Environ. Health. 32:1991;415-427.
34. Yu P.H., Zuo D.-M. Oxidative deamination of methylamine by semicarbazide-sensitive amine oxidase leads to cytotoxic damage in endothelial cells. Possible consequences for diabetes. Diabetes. 42:1993;594-603.
35. Yu P.H., Zuo D.-M. Formaldehyde produced endogenously via deamination of methylamine. A potential risk factor for initiation of endothelial injury. Atherosclerosis. 120:1996;189-197.
36. Yu P.H., Lai C.-T., Zuo D.-M. Formation of formaldehyde from adrenaline; a potential risk factor for stress-related angiopathy. Neurochem. Res. 22(5):1997;615-620.