pH-sensitive noncrosslinked poly (vinyl alcohol-co-acrylic acid) hydrogels for site specific drug delivery

Saudi Pharmaceutical Journal

Volumn 7, Issue 3, 1999, Pages 137-143

  Ranjha, N M ^a   Doelker, E ^b  

^a BAHAUDDIN ZAKARIYA UNIVERSITY   (Pakistan)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Acrylic acid; Colonic drug delivery; Copolymer; PH Sensitive hydrogels; Swelling; Vinyl alcohol

Indexed keywords

ACRYLIC ACID; BETAMETHASONE; HYDROCHLORIC ACID; HYDROXYL GROUP; LACTONE; POTASSIUM HYDROXIDE; VINYL ACETATE;

ARTICLE; CROSS LINKING; DRUG DELIVERY SYSTEM; DRUG RELEASE; HYDROGEL; HYDROLYSIS; PH; POLYMERIZATION;

EID: 0032693449     PISSN: 13190164     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Ranjha NM and Doelker E. pH-Sensitive hydrogels for site specific drug delivery. 1. Swelling behaviour of crosslinked copolymers of acrylic and methacrylic acid. S. T. P. Pharma Sciences (submitted).
2. Ranjha NM Doelker E. pH-Sensitive hydrogels for site specific drug delivery. II. Drug release behaviour from crosslinked alkyl acrylates-methacrylic acid copolymers. S. T. P. Pharma Sciences (submitted).
3. Pye G, Evans DF, Ledingham S and Hardcastle JD. Gastrointestinal intraluminal pH in normal subjects and those with colorectal adenoma or carcinoma. Gut 1990; 31: 1355-1357.
4. Mrsny RJ. The colon as a site for drug delivery. J. Control. Rel. 1992; 22: 15-34.
5. Watts PJ and Illum L. Colonic drug delivery. Drug Dev. Ind. Pharm 1997; 23: 893-913.
6. Gander B, Gurny R, Doelker E and Peppas NA. Effect of polymeric network structure on drug release from crosslinked poly(vinyl alcohol) micromatrices. Pharm. Res. 1989; 6: 578-584.
7. Gander B, Beltrami V, Gurny R and Doelker E. Effect of the method of drug incorporation and the size of the monolith on drug release from cross-linked polymers. Int. J. Pharm. 1990; 58: 63-71.
8. Bettini R, Colombo P and Peppas NA. Solubility effects on drug transport through pH-sensitive, swelling controlled release systems: Transport of theophylline and metoclopramide monohydrochloride. J. Control. Rel. 1995; 37: 105-111.
9. Bourdais J. Réactivité de l'acide acrylique dans les copolymérisations. Bull. Soc. Chim. Fr. 1955; 485-489
10. Philips M. Improved method for determination of percentage acetyl in organic compounds. Ind. Eng. Chem. 1934; 15: 321-322.
11. Peppas NA and Barr-Howel BD. Characterization of the cross-linked structure of hydrogels. In: Peppas NA, ed. Hydrogels in Medicine and Pharmacy Vol I Fundamentals. CRC Press, Boca Raton, Florida, 1987: 27-56.
12. Lindsjo MC, Ekman KB and Nasman JH. Glass-ionomer cements based on poly (acrylic acid-co-vinyl alcohol) in drug release model formulations. Biomaterials 1996; 17: 913-919.
13. Peppas NA and Gehr TWB. New hydrophilic copolymers for biomedical applications. Trans Am. Soc. Artif. Intern. Organ 1978; 24: 404-410.
14. Ranjha NM. Synthesis and characterization of noncrosslinked and crosslinked poly(vinyl alcohol-co-crotonic acid) hydrogels. (Accepted in Saudi Pharmaceutical Journal).
15. Kenyon WO, Murray TF and Minsk LM. Deesterification of copolymers of acrylic esters and vinyl esters. US Patent 1946; 2403004.
16. Fikentscher H. Artificial composition. US Patent 1937; 2067706.
17. Komeda Y and Hottori K. Intramolecular lactonization of saponified vinyl acetate-maleic acid copolymer. Kogyo Kagaku Zasshi 1968; 71: 557, [through C. A. 1968; 69: 59615g].
18. Sakurada I and Kawashima K. The composition and structure of copolymers from vinyl acetate and methyl acrylate. Kobunshi Kagaku 1951; 8: 142, [through C. A. 1953; 47: 344e].
19. Matsumoto T. Copolymerization of vinyl acetate and methyl acrylate and saponification of the copolymer. Kobunshi Kagaku 1950; 7: 142, [through C. A. 1951; 45: 7816h].
20. El-Egakey MA, Soliva M and Speiser P. Hot extruded dosage form. Pharm. Acta Helv. 1971; 46: 31-52.
21. Greenwald HL and Luskin LS. In: Davidson RL (ed.). Handbook of water-soluble gums and resins. McGraw-Hill, New York 1980; 17.1-17.19.
22. Korsmeyer RW and Peppas NA. Macromolecular and modeling aspects of swelling-controlled systems. In: Roseman TJ. and Mansdorf SZ. (ed.). Controlled release delivery systems. Marcel Dekker, New York and Basel 1983; 77-90.
23. Korsmeyer RW, Gurny R, Doelker E, Buri P and Peppas NA. Mechanism of solute release from porous hydrophilic polymers. Int J. Pharm. 1983; 15: 25-35.
24. Peppas NA. Analysis of Fickian and non-Fickian drug release from polymers. Pharm. Acta Helv. 1985; 60: 110-111.