Mass spectrometric (HPLC/ESI-MS/MS) quantification of pyrimido[1,2- a]purin-10(3H)-one, a guanine adduct formed by reaction of malondialdehyde with DNA

Journal of Pharmaceutical and Biomedical Analysis

Volumn 21, Issue 5, 1999, Pages 1053-1061

  Hakala, Kristo ^a   Auriola, Seppo ^b   Koivisto, Arto ^a   Lönnberg, Harri ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

DNA adduct; HPLC ESI MS MS; Malonaldehyde guanine

Indexed keywords

DEOXYRIBONUCLEOSIDE; DNA; GUANINE; GUANINE DERIVATIVE; MALONALDEHYDE; PYRIMIDO[1,2 A]PURIN 10(3H) ONE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; DNA ADDUCT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MASS SPECTROMETRY; MOLECULAR STABILITY; PRIORITY JOURNAL; QUANTITATIVE ASSAY; REACTION ANALYSIS; SYNTHESIS; VALIDATION PROCESS;

ACIDS; ANIMALS; CATALYSIS; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA; DNA ADDUCTS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KINETICS; MALONDIALDEHYDE; MASS SPECTROMETRY; PURINES; PYRIMIDINE NUCLEOSIDES; PYRIMIDINES;

EID: 0032693369     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(99)00228-9     Document Type: Article

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