Metabolism of ethyl methyl sulphide and sulphoxide in rat microsomal fractions

Xenobiotica

Volumn 29, Issue 11, 1999, Pages 1101-1113

  Nnane, I P ^a,c   Damani, L A ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b The Chinese University of Hong Kong   (Hong Kong)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; ENZYME INDUCING AGENT; ENZYME INHIBITOR; ETHYL METHYL SULPHIDE; SULFIDE; SULFONE; SULFOXIDE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ARTICLE; GAS CHROMATOGRAPHY; LIVER MICROSOME; MALE; NONHUMAN; OXIDATION; RAT;

ANIMALIA;

EID: 0032693221     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/004982599237985     Document Type: Article

References (21)

1. DAHL, S. G., HYORTH, M. and HOUGH, E., 1982, Chlorpromazine, methotrimeprazine and metabolites. Structural changes accompanying the loss of neuroleptic potency by ring sulfoxidation. Molecular Pharmacology, 21, 409-414.
2. DAMANI, L. A. (ed.), 1989, Sulphur-containing Drugs and Related Organic Compounds, vol. 1, part A (Chichester: Ellis Horwood).
3. DAMANI, L. A. and NNANE, I. P., 1996, The assessment of the flavin-containing monooxygenase activity in intact animals. Drug Metabolism and Drug Interaction, 13, 1-28.
4. GIBSON, G. G. and SKETT, P., 1986, Introduction to Drug Metabolism (London: Chapman & Hall).
5. GONZALEZ, F. J., 1990, Molecular genetics of the P-450 superfamily. Pharmacology and Therapeutics, 45, 1-38.
6. HOODI, A. A. and DAMANI, L. A., 1984, Cytochrome P-450 and non-cytochrome P-450 sulphoxidations. Journal of Pharmacy and Pharmacology, 36 (suppl.), 629.
7. KOBAYASHI, S., MURRAY, S., WATSON, D., SESARDIC, D., DAVIS, D. S. and BOOBIS, A. R., 1989, The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man. Biochemical Pharmacology, 38, 2795-2799.
8. LAWTON, M. and PHILPOT, R. M., 1995, Emergence of the flavin-containing monooxygenases gene family. In J. R. Hodgson, J. R. Bend and R. M. Philpot (eds), Biochemical Toxicology. Toxicology Communications, vol. 11 Rayleigh Institute (Raleigh, NC), pp. 1-27.
9. LEMOINE, A., JOHANN, M. and CRESTEIL, T., 1990, Evidence for the presence of distinct flavin-containing monooxygenase in human tissues. Archives in Biochemistry and Biophysics, 276, 336-342.
10. LOWRY, O. H., ROSEBOROUGH, N. S., FARR, A. L. and RANDALL, R. S., 1951, Protein measurement with Folin phenol reagent. Journal of Biological Chemistry, 193, 265-275.
11. MADESCLAIRE, M., 1986, Oxidation of sulphides. Tetrahedron, 42, 5459-5495.
12. MITCHELL, S. C., 1988, Biological consequences of drug sulphoxidation. Drug Metabolism and Drug Interaction, 6, 245-252.
13. MURRAY, M. and REIDY, G. F., 1990, Selectivity in the inhibition of mammalian cytochrome P-450 by chemical agents. Pharmacology Reviews, 42, 85-101.
14. NNANE, I. P. and DAMANI, L. A., 1992, Ethyl methyl Sulphide. A potential probe for monitoring the activity of the flavin-containing monooxygenase in vivo. British Journal of Clinical Pharmacology, 34, 160-161.
15. NNANE, I. P. and DAMANI, L. A., 1997, Gas-liquid chromatographic assay for the sulphoxide and sulphone metabolites of ethyl methyl Sulphide in rat microsomal fractions. Pharmaceutical Research, 14, S551.
16. OAE, S., 1977, Organic Chemistry of Sulphur (New York: Plenum).
17. RENWICK, A. G., EVANS, S. P., SWEATMAN, T. W., CUMBERLAND, J. and GEORGE, C. F., 1982, The role of the gut flora in the reduction of sulphinpyrazone in the rat. Biochemical Pharmacology, 31, 2649-2656.
18. SHRINER, R. L., STRUCK, H. C. and JORISON, W. J., 1930, The preparation and properties of certain sulphoxides and sulphones. Journal of the American Chemical Society, 52, 2060-2090.
19. TRAFICANTE, L. J. SIEKIERSKI, J., SAKALIS, G. and GERSHON, S., 1979, Sulfoxidation of chlorpromazine and thioridazine by bovine liver - preferential metabolic pathways. Biochemical Pharmacology, 28, 621-626.
20. ZIEGLER, D. M., 1980, Microsomal flavin-containing monooxygenases: oxygenation of nucleophilic nitrogen and sulphur compounds. In W. B. Jacoby (ed.), Enzymatic Basis of Detoxification, vol. 1 (New York: Academic Press), pp. 201-227.
21. ZIEGLER, D. M., 1990, Flavin-containing monooxygenases: enzymes adapted for multisubstrate specificity. TIPS, 11, 321-324.