Forebrain ischaemia with CA1 cell loss impairs epileptogenesis in the tetanus toxin limbic seizure model

Brain

Volumn 122, Issue 6, 1999, Pages 1009-1016

  Milward, A J ^a   Meldrum, B S ^b   Mellanby, J H ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

CA1; Cerebral ischaemia; Epilepsy; Tetanus toxin

Indexed keywords

TETANUS TOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; COMPLEX PARTIAL SEIZURE; CONTROLLED STUDY; EPILEPTOGENESIS; FOREBRAIN; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0032692278     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/122.6.1009     Document Type: Article

References (49)

1. Armstrong DD. The neuropathology of temporal lobe epilepsy. [Review]. J Neuropathol Exp Neurol 1993; 52: 433-43.
2. Babb TL, Kupfer WR, Pretorius JK. Recurrent excitatory circuits by 'sprouted' mossy fibers into the fascia dentata of human hippocampal epilepsy [abstract]. Epilepsia 1988b; 29: 674.
3. Babb TL, Kupfer WR, Pretorius JK, Crandall PH, Levesque MF. Synaptic reorganization of mossy fibers in human epileptic fascia dentata. Neuroscience 1991; 42: 351-63.
4. Brace HM, Jefferys JG, Mellanby J. Long-term changes in hippocampal physiology and learning ability of rats after intrahippocampal tetanus toxin. J Physiol (Lond) 1985; 368: 343-57.
5. Brierley JB, Meldrum BS, Brown AW. The threshold and neuropathology of cerebral 'anoxic-ischemic' cell change. Arch Neurol 1973; 29: 367-74.
6. Bruton CJ. The neuropathology of temporal lobe epilepsy. The Institute of Psychiatry, Maudsley Monographs, No. 31. Oxford: Oxford University Press; 1988.
7. Cavanagh JB, Meyer A. Aetiological aspects of Ammon's horn sclerosis associated with temporal lobe epilepsy. Brit Med J 1956; 2: 1403-7.
8. Chakravarty DN, Babb TL, Chung CK, Mikuni N. Bilateral kainic acid lesions in the rat hilus induce non-linear additive mossy fiber neoinnervation. Neurosci Lett 1997; 230: 175-8.
9. Cronin J, Dudek FE. Chronic seizures and collateral sprouting of dentate mossy fibers after kainic acid treatment in rats. Brain Res 1988; 474: 181-4.
10. De Groot J. The rat forebrain in stereotaxic coordinates. Verhandelingen der Koninklijke Nederlandse Akademie van Wetenschappen, AFD. Natuurkunde. Amsterdam: N.V. Noord-Hollandsche Uitgevers Maatschappij; 1967.
11. Empson RM, Jefferys JG. Synaptic inhibition in primary and secondary chronic epileptic foci induced by intrahippocampal tetanus toxin in the rat. J Physiol (Lond) 1993; 465: 595-614.
12. Falconer MA. Mesial temporal (Ammon's horn) sclerosis as a common cause of epilepsy. Aetiology, treatment, and prevention. Lancet 1974; 2: 767-70.
13. Finnerty GT. Factors determining the transition to seizure in the tetanus toxin model of epilepsy [PhD thesis]. London: University of London; 1993.
14. Finnerty GT, Jefferys JG. Functional connectivity from CA3 to the ipsilateral and contralateral CA1 in the rat dorsal hippocampus. Neuroscience 1993; 56: 101-8.
15. Frotscher M, Zimmer J. Lesion-induced mossy fibers to the molecular layer of the rat fascia dentata: identification of postsynaptic granule cells by the Golgi-EM technique. J Comp Neurol 1983; 215: 299-311.
16. George G, Mellanby J. Memory deficits in an experimental hippocampal epileptiform syndrome in rats. Exp Neurol 1982; 75: 678-89.
17. Hawkins CA. Studies on an animal model of temporal lobe epilepsy [DPhil thesis]. Oxford: University of Oxford; 1985.
18. Hawkins CA, Mellanby JH. Limbic epilepsy induced by tetanus toxin: a longitudinal electroencephalographic study. Epilepsia 1987; 28: 431-14.
19. Hodges H, Sowinski P, Fleming P, Kershaw TR, Sinden JD, Meldrum BS, et al. Contrasting effects of fetal CA1 and CA3 hippocampal grafts on deficits in spatial learning and working memory induced by global cerebral ischemia in rats. Neuroscience 1996; 72: 959-88.
20. Honavar M, Meldrum BS. Epilepsy. In: Graham DI, Lantos PL, editors. Greenfield's Neuropathology, Vol. 1. 6th ed. London: Arnold; 1997. p. 931-71.
21. Houser CR, Miyashiro JE, Swartz BE, Walsh GO, Rich JR and Delgado-Escueta AV. Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy. J Neurosci 1990; 10: 267-82.
22. Jefferys JG. Chronic epileptic foci in vitro in hippocampal slices from rats with the tetanus toxin epileptic syndrome. J Neurophysiol 1989; 62: 458-68.
23. Jefferys JG, Whittington MA. Review of the role of inhibitory neurons in chronic epileptic foci induced by intracerebral tetanus toxin. Epilepsy Res 1996; 26: 59-66.
24. Jefferys JG Williams SF. Physiological and behavioural consequences of seizures induced in the rat by intrahippocampal tetanus toxin. Brain 1987; 110: 517-32.
25. Jones RS. Entorhinal-hippocampal connections: a speculative view of their function. [Review]. Trends Neurosci 1993; 16: 58-64.
26. Lekieffre D, Meldrum BS. The pyrimidine-derivative, BW1003C87, protects CA1 and striatal neurons following transient severe forebrain ischaemia in rats. A microdialysis and histological study. Neuroscience 1993; 56: 93-9.
27. Margerison JH, Corsellis JA. Epilepsy and the temporal lobes: a clinical, electroencephalographic and neuropathological study of the brain in epilepsy, with particular reference to the temporal lobes. Brain 1966; 89: 499-530.
28. Mathern GW, Babb TL, Levesque MF. Onset and extent of mossy fiber 'sprouting' in the hippocampus of the in vivo rat kainate seizure model [abstract]. Epilepsia 1990; 31: 675.
29. Mathern GW, Babb TL, Mische] PS, Vinters HV, Pretorius JK, Leite JP, et al. Childhood generalized and mesial temporal epilepsies demonstrate different amounts and patterns of hippocampal neuron loss and mossy fibre synaptic reorganization. Brain 1996; 119: 965-87.
30. Meldrum BS. Epileptic brain damage: A consequence and a cause of seizures. [Review]. Neuropathol Appl Neurobiol 1997; 23: 185-202.
31. Mellanby J. Tetanus toxin as a tool for investigating the consequences of excessive neuronal excitation. In: Dasgupta BR, editor. Botulinum and tetanus neurotoxins. New York: Plenum Press; 1993. p. 291-7.
32. Mellanby J and Sundstrom L. Kindling, behaviour and memory. In: Bolwig TG, Trimble MR, editors. The clinical relevance of kindling. Chichester: John Wiley; 1989. p. 103-11.
33. Mellanby J, Mellanby H, Pope D, van Heyningen WE. Ganglioside as a prophylactic agent in experimental tetanus in mice. J Gen Microbiol 1968; 54: 161-8.
34. Mellanby J, George G, Robinson A, Thompson P. Epileptiform syndrome in rats produced by injecting tetanus toxin into the hippocampus. J Neurol Neurosurg Psychiatry 1977; 40: 404-14.
35. Mellanby J, Renshaw M, Cracknell H, Rands G, Thompson P. Long-term impairment of learning ability in rats after an experimental hippocampal epileptiform syndrome. Exp Neurol 1982; 75: 690-9.
36. Mellanby J, Hawkins C, Mellanby H, Rawlins JN, Impey ME. Tetanus toxin as a tool for studying epilepsy. J Physiol (Paris) 1984; 79: 207-15.
37. Mellanby J, Hawkins C, Baillie-Hamilton S, Bourne M, Shepherd L, Stroud C. Kindling, behaviour and anticonvulsant drugs. In: Trimble MR, editor. The psychopharmacology of epilepsy. Chichester: John Wiley; 1985. p. 17-31.
38. Milward AJ. Pathology in tetanus toxin-induced epilepsy. [DPhil thesis]. Oxford: University of Oxford; 1997.
39. Mitchell J, Gatherer M, Sundstrom LE. Aberrant Timm-stained fibres in the dentate gyrus following tetanus toxin-induced seizures in the rat. Neuropathol Appl Neurobiol 1996; 22: 129-35.
40. Nadler JV, Perry BW, Cotman CW. Selective reinnervation of hippocampal area CA1 and the fascia dentata after destruction of CA3-CA4 afferents with kainic acid. Brain Res 1980; 182: 1-9.
41. Netto CA, Hodges H, Sinden JD, Le Peillet E, Kershaw T, Sowinski P, et al. Effects of fetal hippocampal field grafts on ischaemic-induced deficits in spatial navigation in the water maze. Neuroscience 1993; 54: 69-92.
42. Pulsinelli WA, Brierley JB. A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 1979; 10: 267-72.
43. Pulsinelli WA, Brierley JB, Plum F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 1982; 11: 491-8.
44. Sagar HJ, Oxbury JM. Hippocampal neuron loss in temporal lobe epilepsy: correlation with early childhood convulsions. Ann Neurol 1987; 22: 334-40.
45. Sloviter RS. Reorganization hypothesis of epilepsy; granule cell sprouting in rats is associated with decreased, not increased, excitability [abstract]. Epilepsia 1990; 31: 675.
46. Sloviter RS. Possible functional consequences of synaptic reorganization in the dentate gyrus of kainate-treated rats. Neurosci Lett 1992; 137: 91-6.
47. Sutula T, He XX, Cavazos J and Scott G. Synaptic reorganization in the hippocampus induced by abnormal functional activity. Science 1988; 239: 1147-50.
48. Tauck DL, Nadler JV. Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats. J Neurosci 1985; 5: 1016-22.
49. Wikmark RG, Divac I, Weiss R. Retention of spatial delayed alternation in rats with lesions in the frontal lobes. Implications for a comparative neuropsychology of the prefrontal system. Brain Behav Evol 1973; 8: 329-39.