Optimisation of docosahexaenoic acid production in batch cultivations by Crypthecodinium cohnii

Journal of Biotechnology

Volumn 70, Issue 1-3, 1999, Pages 185-192

  De Swaaf, Martin E ^a   De Rijk, Theo C ^a   Eggink, Gerrit ^a   Sijtsma, Lolke ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Bioreactor; Crypthecodinium cohnii; Cultivation; Docosahexaenoic acid; Marine; Medium composition

Indexed keywords

ANTIFOAMING AGENT; DOCOSAHEXAENOIC ACID; GLUCOSE;

ALGA; BIOACCUMULATION; BIOREACTOR; CONFERENCE PAPER; GROWTH; LIPID ANALYSIS; LIPID COMPOSITION; NONHUMAN; PRIORITY JOURNAL; TEMPERATURE; YEAST;

CRYPTHECODINIUM COHNII;

BATCH CELL CULTURE; BIOMASS; BIOREACTORS; COMPOSITION EFFECTS; FATTY ACIDS; GLUCOSE; LIPIDS; PLANT CELL CULTURE; SEAWATER; SODIUM CHLORIDE; THERMAL EFFECTS; YEAST;

DOCOSAHEXAENOIC ACID;

ALGAE;

EID: 0032659336     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(99)00071-1     Document Type: Conference Paper

References (29)

1. Barclay W.R., Meager K.M., Abril J.R. Heterotrophic production of long chain omega-3 fatty acids utilizing algae and algae-like microorganisms. J. Appl. Phycol. 6:1994;123-129.
2. Beach D.H., Holz G.G. Environmental influences on the docosahexaenoate content of the triacylglycerols and phosphatidylcholine of a heterotrophic, marine dinoflagellate, Crythecodinium cohnii. Biochim. Biophys. Acta. 316:1973;56.
3. Beach D.H., Harrington G.W., Gellerman J.L., Schlenk H., Holz G.G. Biosynthesis of oleic acid and docosahexaenoic acid by a heterotrophic marine dinoflagellate Crythecodinium cohnii. Biochim. Biophys. Acta. 369:1974;16-24.
4. Bell M.V., Henderson R.J. Molecular species composition of phosphatidylcholine from Crypthecodinium cohnii in relation to growth temperature. Lipids. 25:1990;115-118.
5. Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37:1959;911.
6. Braden L.M., Carroll K.K. Dietary polyunsaturated fat in relation to mammary carcinogenesis in rats. Lipids. 21:1986;285-288.
7. Butte W. Rapid method for the determination of fatty acid profiles from fats and oils using trimethylsulphonium hydroxide for transesterification. J. Chromatogr. 261:1983;142-145.
8. Carlson S.E. Arachidonic acid status of human infants: influence of gestational age at birth and diets with very long chain n-3 and n-6 fatty acids. J. Nutr. 126:1996;1092-1098.
9. Christie W.W. Lipid Analysis. 1973;85-102 Pergamon Press, Oxford.
10. Dyerberg J. Linolenate-derived polyunsaturated fatty acids and prevention of atherosclerosis. Nutr. Rev. 44:1986;125-134.
11. Grayburn W.S., Collins G.B., Hildebrand D.F. Fatty acid alteration by a δ-9 desaturase in transgenic tobacco tissue. Bio/Technology. 10:1992;675-678.
12. Harrington G.W., Holz G.G. The monoenoic and docosahexaenoic fatty acids of a heterotrophic dinoflagellate. Biochim. Biophys. Acta. 164:1968;137-139.
13. Henderson R.J., Mackinlay E.E. Polyunsaturated fatty acid metabolism in the marine dinoflagellate Crypthecodinium cohnii. Phytochemistry. 30:1991;1781-1787.
14. Henderson R.J., Leftley J.W., Sargent J.R. Lipid composition and biosynthesis in the marine dinoflagellate Crypthecodinium cohnii. Phytochemistry. 27:1988;1679-1683.
15. Huisman, M., 1996. Effects of early infant nutrition and perinatal exposure to PCBs and dioxins on neurological development. Ph.D. Thesis. Rijksuniversiteit Groningen, Groningen, The Netherlands.
16. Ishida Y. Physiological studies on evolution of dimethyl sulfide from unicellular marine algae. Mem. Res. Inst. Food Sci. Kyoto Univ. 94:1968;48-82.
17. Kremer J.M., Bigauoette J., Michalek A.V., Timchalk M.A., Lininger L., Rynes R.I., Huyck C., Zieminski J., Bartholomew L.E. Effects of manipulation of dietary fatty acids on clinical manifestations of rheumatoid arthritis. Lancet. 1:1985;184-187.
18. Kyle D.J. Production and use of a single cell oil which is highly enriched in docosahexaenoic acid. Lipid Technol. 8:1996;107-110.
19. Kyle D.J., Sicotte V.J., Singer J.J., Reeb S.E. Bioproduction of docosahexaenoic acid (DHA) by microalgae. Kyle D.J., Radledge C. Industrial Applications of Single Cell Oils. 1992;287-300 American Oil Chemists' Society, Champaign, IL.
20. Leman J. Oleaginous microorganisms: an assessment of the potential. Adv. Appl. Microbiol. 43:1997;195-243.
21. Mehta J., Lopez L.M., Wargovich T. Eicosapentaenoic acid: its relevance in atherosclerosis and coronary artery disease. Am. J. Cardiol. 59:1987;155-159.
22. Nettleton J.A. Are n-3 fatty acids essential nutrients for fetal and infant development? J. Am. Dietetic Assoc. 93:1993;58-64.
23. Reddy B.S., Maruyama H. Effect of dietary fish oil on azoxymethane-induced colon carcinogenesis in male F344 rats. Cancer Res. 46:1986;3367-3370.
24. Sijtsma L., Springer J., Meesters P.A.E.P., de Swaaf M.E., Eggink G. Recent advances in fatty acid synthesis in oleaginous yeasts and microalgae. Recent Res. Dev. Microbiol. 2:1998;219-232.
25. Trinder P. Determination of glucose in blood using glucose oxidase with alternative oxygen acceptor. Ann. Clin. Biochem. 6:1969;24.
26. Tuttle R.C., Loeblich A.R. An optimal growth medium for the dinoflagellate Crypthecodinium cohnii. Phycologia. 14:1975;1-8.
27. Urakaze M., Hamazaki T., Soda Y., Miyamota M., Ibuki F., Yano S., Kumagai A. Infusion of emulsified trieicosapentaenoyl-glycerol into rabbits - the effects on platelet aggregation, polymorphonuclear leukocyte adhesion, and fatty acid composition in plasma and platelet phospholipids. Thromb. Res. 44:1986;673-682.
28. Vazhappilly R., Chen F. Eicosapentaenoic acid and docosahexaenoic acid production potential of microalgae and their heterotrophic growth. J. Am. Oil Chem. Soc. 75:1998;393-397.
29. Wiley/NIST Combined Library, 1994, 6th ed., Wiley-Interscience, New York.