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Volumn 77, Issue 3, 1999, Pages 602-607

Plasmid stability analysis in a non-homogeneous bioreactor for a recombinant fed-batch fermentation

Author keywords

Fed batch fermentation; Imperfect macromixing; Plasmid stability; Recombinant E. coli

Indexed keywords

BIOREACTORS; CELL CULTURE; ENZYMES; FLOW OF FLUIDS; GROWTH KINETICS; MATHEMATICAL MODELS; MIXING; ORGANIC COMPOUNDS;

EID: 0032648483     PISSN: 00084034     EISSN: None     Source Type: Journal    
DOI: 10.1002/cjce.5450770325     Document Type: Article
Times cited : (5)

References (25)
  • 1
    • 0019393944 scopus 로고
    • A perspective on the application of genetic engineering: Stability of recombinant plasmid
    • Imanaka, T. and S. Aiba, "A Perspective on the Application of Genetic Engineering: Stability of Recombinant Plasmid", Ann. N.Y. Acad. Sci. 369, 1-14 (1981).
    • (1981) Ann. N.Y. Acad. Sci. , vol.369 , pp. 1-14
    • Imanaka, T.1    Aiba, S.2
  • 2
    • 0023279144 scopus 로고
    • Bacteriocin production as a method of maintaining plasmid-bearing cells in continuous culture
    • Lauffenberger, D. A., "Bacteriocin Production as a Method of Maintaining Plasmid-bearing Cells in Continuous Culture", Trends Biotechnol. 5, 87-89 (1987).
    • (1987) Trends Biotechnol. , vol.5 , pp. 87-89
    • Lauffenberger, D.A.1
  • 3
    • 0024017382 scopus 로고
    • Performance of recombinant fermentation and evaluation of gene expression efficiency for gene production in two-stage continuous culture system
    • Lee, S. B., D. D. Y. Ryu, R. Siegel and S. H. Park, "Performance of Recombinant Fermentation and Evaluation of Gene Expression Efficiency for Gene Production in Two-stage Continuous Culture System", Biotechnol. Bioeng. 31, 805-820 (1988).
    • (1988) Biotechnol. Bioeng. , vol.31 , pp. 805-820
    • Lee, S.B.1    D D Y, R.2    Siegel, R.3    Park, S.H.4
  • 4
    • 0028484018 scopus 로고
    • Using measurement data in bioprocess modelling and control
    • Lubbert, A. and R. Simutis, "Using Measurement Data in Bioprocess Modelling and Control", Trends Biotechnol. 12, 304-311 (1994).
    • (1994) Trends Biotechnol. , vol.12 , pp. 304-311
    • Lubbert, A.1    Simutis, R.2
  • 5
    • 0026473150 scopus 로고
    • Engineering approach to mixing quantification in bioreactors
    • Mayr, B., P. Horvat and A. Moser, "Engineering Approach to Mixing Quantification in Bioreactors", Bioprocess Eng. 8, 137-143 (1992).
    • (1992) Bioprocess Eng. , vol.8 , pp. 137-143
    • Mayr, B.1    Horvat, P.2    Moser, A.3
  • 6
    • 0027948854 scopus 로고
    • A suboptimal solution to the optimisation of bioreactors using the chemotaxis algorithm
    • Montague, G. A. and A. C. Ward, "A Suboptimal Solution to the Optimisation of Bioreactors using the Chemotaxis Algorithm", Process Biochem. 29, 489-496 (1994).
    • (1994) Process Biochem. , vol.29 , pp. 489-496
    • Montague, G.A.1    Ward, A.C.2
  • 7
    • 0026816501 scopus 로고
    • Study of population dynamic for a recombinant bacterium during cultures: Application and data filtering and smoothing
    • Nancib, N., R. Mosrati and J. Boudrant, "Study of Population Dynamic for a Recombinant Bacterium During Cultures: Application and Data Filtering and Smoothing", Biotechnol. Bioeng. 39, 398-407 (1992).
    • (1992) Biotechnol. Bioeng. , vol.39 , pp. 398-407
    • Nancib, N.1    Mosrati, R.2    Boudrant, J.3
  • 8
    • 0026416595 scopus 로고
    • Determination of kinetic parameters related to the plasmid stability: For the recombinant fermentation under repressed condition
    • Park, S. H., D. D. Y. Ryu and S. B. Lee, "Determination of Kinetic Parameters Related to the Plasmid Stability: for the Recombinant Fermentation under Repressed Condition", Biotechnol. Bioeng. 37, 404-414 (1991).
    • (1991) Biotechnol. Bioeng. , vol.37 , pp. 404-414
    • Park, S.H.1    Ryu, D.D.Y.2    Lee, S.B.3
  • 9
    • 0027791015 scopus 로고
    • The effect of macromixing on oscillatory behavior in recombinant fermentation in a continuous stirred tank reactor
    • Patnaik, P. R., "The Effect of Macromixing on Oscillatory Behavior in Recombinant Fermentation in a Continuous Stirred Tank Reactor", Chem. Eng. Commun. 125, 155-169 (1993).
    • (1993) Chem. Eng. Commun. , vol.125 , pp. 155-169
    • Patnaik, P.R.1
  • 10
    • 0002095427 scopus 로고
    • Does macromixing affect plasmid stability during continuous fermentation with recombinant bacteria?
    • Patnaik, P. R., "Does Macromixing Affect Plasmid Stability During Continuous Fermentation with Recombinant Bacteria?", Indian Chem. Engr. 36, 85-88 (1994a).
    • (1994) Indian Chem. Engr. , vol.36 , pp. 85-88
    • Patnaik, P.R.1
  • 11
    • 0028671079 scopus 로고
    • Micromixing and the steady-state performance of bioreactors using recombinant bacteria - Analysis through a reversed two-environment model
    • Patnaik, P. R., "Micromixing and the Steady-state Performance of Bioreactors using Recombinant Bacteria - Analysis Through a Reversed Two-environment Model", J. Chem. Technol. Biotechnol. 61, 337-342 (1994b).
    • (1994) J. Chem. Technol. Biotechnol. , vol.61 , pp. 337-342
    • Patnaik, P.R.1
  • 12
    • 0030065721 scopus 로고    scopus 로고
    • Incomplete mixing in large reactors - A study of its role in the fermentative production of streptokinase
    • Patnaik, P. R., "Incomplete Mixing in Large Reactors - a Study of its Role in the Fermentative Production of Streptokinase", Bioprocess Eng. 14, 91-96 (1996a).
    • (1996) Bioprocess Eng. , vol.14 , pp. 91-96
    • Patnaik, P.R.1
  • 13
    • 0039801524 scopus 로고    scopus 로고
    • Imperfect mixing in a batch bioreactor for a class of microbial reactions with dual inhibition - Performance analysis for two methods of inoculation
    • Allied Publishers, New Delhi, India
    • Patnaik, P. R., "Imperfect Mixing in a Batch Bioreactor for a Class of Microbial Reactions with Dual Inhibition - Performance Analysis for Two Methods of Inoculation", "in Advances in Chemical Engineering", Allied Publishers, New Delhi, India (1996b), pp. 335-340.
    • (1996) Advances in Chemical Engineering , pp. 335-340
    • Patnaik, P.R.1
  • 14
    • 0039801525 scopus 로고    scopus 로고
    • Dispersion-induced behavior in sub-critical operation of a recombinant fed-batch fermentation with run-away plasmids
    • in press
    • Patnaik, P. R., "Dispersion-induced Behavior in Sub-critical Operation of a Recombinant Fed-batch Fermentation with Run-away Plasmids", Bioprocess Eng. (in press, 1999).
    • (1999) Bioprocess Eng.
    • Patnaik, P.R.1
  • 15
    • 0028485098 scopus 로고
    • Characterisation of mixing in stirred tank bioreactors equipped with rushton turbines
    • Pedersen, A. G., M. B. Nielsen, J. Nielsen and J. Villadsen, "Characterisation of Mixing in Stirred Tank Bioreactors Equipped with Rushton Turbines", Biotechnol. Bioeng. 44, 1013-1017 (1994).
    • (1994) Biotechnol. Bioeng. , vol.44 , pp. 1013-1017
    • Pedersen, A.G.1    Nielsen, M.B.2    Nielsen, J.3    Villadsen, J.4
  • 16
    • 84952899847 scopus 로고
    • Stirred tank models
    • H.-J. Rehm and G. Reed, Eds., VCH Verlagsgesellschaft, Weinheim, Germany
    • Reuss, M. and R. Bajpai, "Stirred Tank Models", in "Biotechnology", Vol. 4, H.-J. Rehm and G. Reed, Eds., VCH Verlagsgesellschaft, Weinheim, Germany (1991), pp. 299-348.
    • (1991) Biotechnology , vol.4 , pp. 299-348
    • Reuss, M.1    Bajpai, R.2
  • 17
  • 18
    • 0027884018 scopus 로고
    • On the modelling approaches of biomass behaviour in bioreactor
    • Ruggeri, B. and G. Sassi, "On the Modelling Approaches of Biomass Behaviour in Bioreactor", Chem Eng. Commun. 122, 1-56 (1993).
    • (1993) Chem Eng. Commun. , vol.122 , pp. 1-56
    • Ruggeri, B.1    Sassi, G.2
  • 19
    • 0021913325 scopus 로고
    • "Kinetic study of the instability of recombinant plasmid pPLc23trpA1 in E. coli using two-stage continuous culture system
    • Siegel, R. and D. D. Y. Ryu, "Kinetic Study of the Instability of Recombinant Plasmid pPLc23trpA1 in E. coli using Two-stage Continuous Culture System", Biotechnol. Bioeng. 27, 28-33 (1985).
    • (1985) Biotechnol. Bioeng. , vol.27 , pp. 28-33
    • Siegel, R.1    Ryu, D.D.Y.2
  • 20
    • 0024278493 scopus 로고
    • Effect of cycling on the stability of plasmid-bearing microorganisms in continuous culture
    • Stephens, M. L. and G. Lyberatos, "Effect of Cycling on the Stability of Plasmid-bearing Microorganisms in Continuous Culture", Biotechnol. Bioeng. 31, 464-469 (1988).
    • (1988) Biotechnol. Bioeng. , vol.31 , pp. 464-469
    • Stephens, M.L.1    Lyberatos, G.2
  • 21
    • 0025863499 scopus 로고
    • The kinetics of plasmid loss
    • Summers, M. L., "The Kinetics of Plasmid Loss", Trends Biotechnol. 9, 273-278 (1991).
    • (1991) Trends Biotechnol. , vol.9 , pp. 273-278
    • Summers, M.L.1
  • 22
    • 0013725110 scopus 로고
    • The effect of imperfect mixing on an idealised kinetic fermentation model
    • Tanner, R. D., I. J. Dunn, J. R. Bourne and M. K. Klu, "The Effect of Imperfect Mixing on an Idealised Kinetic Fermentation Model", Chem. Eng. Sci. 40, 1213-1219 (1985).
    • (1985) Chem. Eng. Sci. , vol.40 , pp. 1213-1219
    • Tanner, R.D.1    Dunn, I.J.2    Bourne, J.R.3    Klu, M.K.4
  • 23
    • 0027201597 scopus 로고
    • Use of a simple mathematical model to predict the behavior of Escherichia coli overproducing β-lactamase within continuous single- and two-stage reactor systems
    • Togna, A. P., J. Fu and M. L. Schuler, "Use of a Simple Mathematical Model to Predict the Behavior of Escherichia coli Overproducing β-lactamase within Continuous Single- and Two-stage Reactor Systems", Biotechnol. Bioeng. 42, 557-570 (1993).
    • (1993) Biotechnol. Bioeng. , vol.42 , pp. 557-570
    • Togna, A.P.1    Fu, J.2    Schuler, M.L.3
  • 24
    • 0024751604 scopus 로고
    • Dynamics of plasmid maintenance in a CSTR upon square-wave perturbations in the dilution rate
    • Weber, A. E. and K.-Y. San, "Dynamics of Plasmid Maintenance in a CSTR upon Square-wave Perturbations in the Dilution Rate", Biotechnol. Bioeng. 34, 1104-1113 (1989).
    • (1989) Biotechnol. Bioeng. , vol.34 , pp. 1104-1113
    • Weber, A.E.1    San, K.-Y.2
  • 25
    • 0027015640 scopus 로고
    • Recombinant protein expression in high cell density fed-batch cultures of Escherichia coli
    • Yee, L. and H. W. Blanch, "Recombinant Protein Expression in High Cell Density Fed-batch Cultures of Escherichia coli", Bio/Technology 10, 1550-1556 (1992).
    • (1992) Bio/Technology , vol.10 , pp. 1550-1556
    • Yee, L.1    Blanch, H.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.