Syntheses and antitumor activities of medium molecular weight polymers containing a-ethoxy-exo-3,6-epoxy1,2,3,6-tetrahydrophthaloyi-5-fluorouracii

Journal of Polymer Science, Part A: Polymer Chemistry

Volumn 37, Issue 14, 1999, Pages 2619-2627

  Lee, Sun Mi ^a   Choi, Won Moon ^a   Chang Sik, H A ^a   Cho, Won Jei ^a  

^a Pusan National University   (South Korea)

Author keywords

A ethoxy exo 3,6 epoxy l,2,3,6 tetrahydrophthaloyl 5 fluorouracil (EETFU); In vitro cytotoxicities; In vivo antitumor activities; Medium molecular weight polymer (MMWP); Polymers containing 5 fluorouracil

Indexed keywords

CHEMICAL ANALYSIS; CYTOLOGY; DRUG PRODUCTS; FOURIER TRANSFORM INFRARED SPECTROSCOPY; GEL PERMEATION CHROMATOGRAPHY; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOTOPOLYMERIZATION; SYNTHESIS (CHEMICAL); TOXICITY;

ANTITUMOR ACTIVITIES; CYTOTOXICITIES; ETHOXYEXOEPOXY TETRAHYDROPHTHALOYL FLUOROURACIL; MEDIUM MOLECULAR WEIGHT POLYMERS;

ORGANIC POLYMERS;

EID: 0032647006     PISSN: 0887624X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-0518(19990715)37:14<2619::AID-POLA36>3.0.CO;2-7     Document Type: Article

References (44)

1. REFERENCES AND NOTES 1. Ringsdorf, H. J Polym Sei Polym Symp Ed 1975,51, 135.
2. Donaruma, L. G., Vogl, O., Eds.; Polymeric Drygs; Academic: New York, 1978.
3. Butler, G. B. J Macromol Sei Chem 1979, A13, 351.
4. Brockman, R. W.; Anderson, E. P. Ann Rev Biochem 1963, 32, 463.
5. Heidelberger, C.; Ansfield, F. J. Cancer Res 1963, 23, 1226.
6. Ozaki, S.; Ike, Y.; Mizuno, H.; Ishikawa, K.; Mon, H. Bull Chem Soc Soc 1977, 50, 2406.
7. Umrigar, R.; Ohashi, S.; Butler., G. B. J Polym Sei Polym Chem Ed 1979, 17, 351.
8. Kametani, T. J Med Chem 1980, 23, 1324.
9. Buur, A.; Bundgaard, H. Int J Pharm 1984,21,349.
10. Ouchi, T.; Yuyama, H.; Vogl, O. Makromal Chem Rapid Commun 1985, 6, 815.
11. Brockman, R. W.; Anderson, E. P. Ann Rev Biochem 1963, 32, 463.
12. Heidelberger, C.; Ansfield, E. J. Cancer Res 1963, 23, 1226.
13. Heidelberger, C. Ann Rev Pharmacol 1975, 7, 115.
14. Prusoff, W. H. Ann Rev Pharmacol 1967, 19, 209.
15. Butler, G. J Polym Sei 1960, 48, 279.
16. Butler, G.; Zampini, A. J Macromol Sei Chem 1977, All, 491.
17. Heidelberger, C. Ann Rev Pharmacol 1967, 7, 155.
18. Prusoff, W. H. Pharmacol 1967, 19, 209.
19. Miller, E. J Sur Ons 1971, 3, 309.
20. Han, M. J.; Lee, C. W.; Kim, K. H.; Yoon, S. H. Macromoleculesv, 25, 3528.
21. Han, M. J.; Chang, Y. S.; Park, J. Y.; Kim, K. H. Macromolecules 1992, 25, 6574.
22. Han, J.; Kim, K. A.; Cho, T. J.; Kim, K. H.; Chang, J. Y. Macromolecules 1994, 27, 2896.
23. Akashi, M.; Miyauchi, N.; Morita, N.; Minota, T. J Bioactive and Compatible Polym 1987, 2, 232.
24. Lee, N. J.; Chio, W. M.; Oh, S. H.; Cho., W. J. IUPAC Preprints, 1987, 295;
25. Chem 1991, 2, l, 56.
26. Lee, N. J.; Ha, C. S.; Cho, W. J. Polymer (Korea) 1991, 15, 2, 211.
27. Shim, M. S.; Lee, N. J.; Ha, C. S.; Cho., W. J. Polymer (Korea) 1991, 15, 4, 489.
28. Lee, N. J.; Ha, C. S.; Cho., W. J. J Macromol Sei Chem 1992, 29, 2, 162.
29. Ha , C. S.; Choi, W. M.; Kim, I. S.; Lee, N. J.; Cho., W. J. J Bioactive and Compatible Polymer 1992, 7, 39.
30. Garn, G. T.; Jeong, J. G.; Lee, N. J.; Lee, Y. W.; Ha, C. S.; Cho., W. J. J Appl Polym Sei 1995, 57, 2, 219.
31. Cho, W. J.; Ha., C. S. Polymer Materials Encyclopedia: Synthesis Properties and Application, Vol. 1; Boca Raton, FL: CRC Press, Inc., 1996; p. 357.
32. Lee, D. Y.; Jeong, J. G.; Lee, N. J.; Kang, H. S.; Ha, C. S.; Cho., W. J. J Appl Polym Sei 1996, 62, 557.
33. Lee, N. J.; Kim, Y. A.; Kim, S. H.; Choi, W. M.; Cho., W. J. J Macromol Sei Chem 1997, A34(l), 1.
34. Choi, W. M.; Lee, N. J.; Lee, Y. W.; Ha, C. S.; Cho., W. J. Macromol Symp 1997, 118, 616.
35. Choi, W. M.; Lee, N. J.; Ha, C. S.; Cho, W. J. Polym Int 1997, 43, 167.
36. Choi, W. M.; Chung, I. D.; Lee, N. J.; Kim, S. H.; Ha, C. S.; Cho, W. J. Polym Adv Technol 1997, 8, 701.
37. Choi, W. M.; Lee, N. J.; Lee, Y. W.; Ha, C. S.; Cho, W. J. Polymer Bulletin 1997, 39, 535.
38. Lee, N. J.; Kim, H. J.; Ock, M. S.; Kim, K. H.; Choi, W. M.; Ha, C. S.; Cho, W. J. Polym Int 1998,45, 92.
39. Park, J. G.; Choi, W. M.; Lee, N. J.; Ha, C. S.; Cho, W. J. J Polym Sei Part A Polym Chem 1998,36,1625.
40. Choi, W. M.; Chung, I. D.; Lee, N. J.; Lee, Y. W.; Ha, C. S.; Cho, W. J. J Polym Sei Part A Polym Chem 1998, 36, 2177.
41. Park, J. G.; Kirn, S. H.; Ha, C. S.; Cho, W. J. J Polym Sei Part A Polym Chem 1998, 36, 2985.
42. Mosmann, T. J Immunol Method 1985, 65, 55.
43. Ottenbrite, R. M. J Macromol Sei Chem 1985, A22,819.
44. Takakura, Y.; Takagi, A.; Hashida, M.; Sezak, H. Pharm Res 1987, 4, 293.