Boron neutron capture enhancement of fast neutron for nonremoved glioblastomas: Rationale of a clinical trial

Frontiers of Radiation Therapy and Oncology

Volumn 33, Issue , 1999, Pages 43-50

  Pignol, J P ^a   Paquis, P ^b   Breteau, N ^c   Chauvel, P ^d   Sauerwein, W ^e  

^a Hopital du Hasenrain CH de Mulhouse   (France)

^b PASTEUR HOSPITAL   (France)

^c CENTRE HOSPITALIER RÉGIONAL D ORLÉANS   (France)

^d CENTRE ANTOINE LACASSAGNE   (France)

^e UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; BRAIN TUMOR; FAST NEUTRON RADIATION; GLIOBLASTOMA; HUMAN; METABOLISM; METHODOLOGY; NEUTRON CAPTURE THERAPY; PHASE 1 CLINICAL TRIAL; RADIATION DOSE; REVIEW;

ANIMALS; BORON NEUTRON CAPTURE THERAPY; BRAIN NEOPLASMS; CLINICAL TRIALS, PHASE I; FAST NEUTRONS; GLIOBLASTOMA; HUMANS; RADIOTHERAPY DOSAGE;

EID: 0032623265     PISSN: 00719676     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (30)

1. Laramore GE: Neutron radiotherapy for high-grade gliomas: The search for the elusive therapeutic window. Int J Radiat Oncol Biol Phys 1990;19:493-495.
2. Caterall M, Bloom HJG, Ash DV, Walsh L, Richardson A, Uttley D, Gowing NFC, Lewis P, Chaucer B: Fast neutrons compared with megavoltage X-rays in the treatment of patients with supratentorial glioblastomas: A controlled pilot study. Int J Radiat Oncol Biol Phys 1980;6:261-266.
3. Duncan W, McLelland J, Jack WJL, Arnott SJ, Gordon A, Kerr GR, Williams JR: The results of a randomised trial of mixed-schedule (neutron/photon) irradiation in the treatment of supratentorial grade III and grade IV astrocytoma. Br J Radiol 1986;59:379-383.
4. Herskovic A, Ornitz RD, Shell M, Rodgers CC: Glioblastoma multiforme treated with 15 MeV fast neutrons. Cancer 1982;49:2463-2465.
5. Laramore GE, Griffin TW, Gerdes AJ, Parker RG: Fast neutron and mixed (neutron/photon) beam teletherapy for grade III and IV astrocytomas. Cancer 1978;42:96-106.
6. Buchholz TA, Laramore GE, Stelzer KJ, Risler R, Wooton P, Griffin TW: Boron neutron capture enhanced fast neutron radiotherapy for malignant gliomas and other tumors. J Neurooncol 1997; 33:171-178.
7. Lüdeman L, Matzen T, Matzke M, Schmidt R, Scobel W: Determination of the thermal neutron flux in a fast neutron beam by use of a boron-coated ionization chamber. Med Phys 1995;22: 1743-1747.
8. Pignol JP, Chauvel P, Paquis P, Courdi A, Iborra-Brassart N, Lonjon M, Lebrun-Frenay C, Frenay M, Grellier P, Chatel, M, Hérault J, Bensadoun RJ, Milano G, Nepveu F, Patau JP, Demard F, Breteau N: Boron neutron capture irradiation: Setting up a clinical programme in Nice. Bull Cancer Radiother 1996;83:201S-206S.
9. Sauerwein W, Zeigler W, Szypniewski H, Streffer C: Boron neutron capture therapy using fast neutrons: Effects in two human tumor cell lines. Strahlenther Onkol 1990;166:26-29.
10. 10B to enhance the tumour dose in fast-neutron therapy. Phys Med Biol 1978;23:592-602.
11. Barth RF, Soloway AH, Fairchild RG, Brugger RM: Boron neutron capture therapy for cancer. Realities and prospects. Cancer 1992;70:2995-3007.
12. Pignol JP, Chauvel P: Irradiations par captures de neutrons: Principe, résultats actuels et perspectives. Bull Cancer Radiother 1995;82:283-297.
13. Barth RG, Yang G, Rotaru JH, Meschberger ML, Joel DD, Nawrocky MM, Goodman JH, Soloway AH: Boron neutron capture therapy of brain tumors: Enhanced survival following intracarotid injection of either sodium borocaptate or boronophenylalanine with or without blood-brain barrier disruption. Cancer Res 1997;57:1129-1136.
14. Yang W, Barth RF, Rotaru JH, Moeschberger ML, Joel DD, Nawrocky MM, Goodman JH, Soloway AH: Boron neutron capture therapy of brain tumors: Enhanced survival following intracarotid injection of sodium borocaptate with or without blood-brain barrier disruption. Int J Radiat Oncol Biol Phys 1997;37:663-672.
15. Pöller F, Sauerwein W, Rassow J: Dosimetry and fluence measurements with a new irradiation arrangement for neutron capture therapy of tumors in mice. Radiother Oncol 1991;21:179-182.
16. Busse PM, Zamenhof R, Madoc-Jones H, Solares G, Kiger S, Riley K, Chuang C, Rogers G, Harling O: Clinical follow-up of patients with melanoma of the extremity treated in a phase I boron neutron capture therapy protocol; in Larsson B et al (eds): Advances in Neutron Capture Therapy, vol I: Medicine and Physics. Amsterdam, Elsevier, 1997, pp 60-64.
17. Coderre JA, Elowitz EH, Chadha M, Bergland R, Capala J, Joel DD, Liu HB, Slatkin DN, Chanana AD: Boron neutron capture therapy for glioblastoma multiforme using p-boronophenylalanine and epithermal neutrons: Trial design and early clinical results. J Neurooncol 1997;33:141-152.
18. Hatanaka H, Nakagawa Y: Clinical results of long-surviving brain patients who underwent boron neutron capture therapy. Int J Radiat Oncol Biol Phys 1994;28:1061-1066.
19. 11SH) in patients with intracranial tumors. J Neurooncol 1997;33:117-130.
20. Sauerwein W: The clinical project at HFR Petten - A status report; in Larsson B et al (eds): Advances in Neutron Capture Therapy, vol I: Medicine and Physics. Amsterdam, Elsevier, 1997, pp 77-82.
21. Capala J, Makar MS, Coderre, JA: Accumulation of boron in malignant and normal cells incubated in vitro with boronophenylalanine, mercaptoborane or boric acid. Radiat Res 1996;146:554-560.
22. Coderre JA, Glass JD, Fairchild RG, Micca PL, Fand I, Joel DD: Selective delivery of boron by the melanin precursor analogue p-boronophenylalanine to tumors other than melanoma. Cancer Res 1990;50:138-141.
23. 11SH (BSH) in patients with malignant brain tumors as a prerequisite for a phase I clinical trial of boron neutron capture. Acta Neurochir 1997;139:606-612.
24. Peters HD, Gabel D: European Collaboration on Boron Neutron Capture Therapy: Compilation of Literature Data on Toxicity and Pharmacokinetics in Animals and Summary of the European Phase I toxicity and pharmacokinetic study. Bremen, European Collaboration on BNCT Editor, 1997, pp 1-14.
25. Ensminger WD:Intraarterial therapy; in Perry MC (ed): The Chemotherapy Source Book. Baltimore, Williams & Wilkins, 1992, pp 256-271.
26. Pignol JP, Courdi A, Paquis P, Iborra-Brassart N, Fares G, Hachem A, Lonjon M, Breteau N, Sauerwein W, Gabel D, Chauvel P: Potentialisation par captures de neutrons pour les gliblastomes inextirpables. J Chim Phys 1997;94:1827-1830.
27. Coderre JA, Makar MS, Micca PL, Nawrocky MM, Liu HB, Joel DD, Slatkin DN, Amols HI: Derivations of relative biological effectiveness for the high LET radiations produced during boron neutron capture irradiations of the 9L rat gliosarcoma in vitro and in vivo. Int J Radiat Oncol Biol Phys 1993;27:1121-1129.
28. Goodman JH, McGregor JM, Clendenon NR: Ultrastructural microvascular response to boron neutron capture therapy in an experimental model. Neurosurgery 1989;24:701-708.
29. Slatkin DN: A history of boron neutron capture therapy of brain tumors. Postulation of a brain radiation dose tolerance limit. Brain 1991;114:1609-1629.
30. Courdi A: Fractionation and therapeutic ratio with neutron therapy. Bull Cancer Radiother 1996; 83:64S-67S.