Effects of inhaled dry powder ipratropium bromide on recovery from exercise of horses with COPD

Equine Veterinary Journal

Volumn 31, Issue 1, 1999, Pages 20-24

  Duvivier, Dominique H ^a   Bayly, W M ^b   Votion, Dominique ^a   Vandenput, Sandrine ^a   Art, Tania ^a   Farnir, F ^a   Lekeux, P ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

COPD; Dry powder inhalation; Exercise; Horse; Ipratropium; Recovery

Indexed keywords

BRONCHODILATING AGENT; CARBON DIOXIDE; CHOLINERGIC RECEPTOR BLOCKING AGENT; IPRATROPIUM BROMIDE;

ANIMAL; ANIMAL DISEASE; ANIMAL EXPERIMENT; ARTICLE; BREATHING MECHANICS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EXERCISE TEST; HEART RATE; HORSE; HORSE DISEASE; INHALATIONAL DRUG ADMINISTRATION; LUNG FUNCTION TEST; LUNG WEDGE PRESSURE; METABOLISM; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; POWDER; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, INHALATION; ANIMALS; BRONCHODILATOR AGENTS; CARBON DIOXIDE; CHOLINERGIC ANTAGONISTS; EXERCISE TEST; HEART RATE; HORSE DISEASES; HORSES; IPRATROPIUM; LUNG DISEASES, OBSTRUCTIVE; OXYGEN CONSUMPTION; PHYSICAL CONDITIONING, ANIMAL; POWDERS; PULMONARY WEDGE PRESSURE; RESPIRATORY FUNCTION TESTS; RESPIRATORY MECHANICS;

EID: 0032616293     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-3306.1999.tb03786.x     Document Type: Article

References (26)

1. Aitken, M.M., Sanford, J. and McKenzie, G. (1973) Factors influencing deceleration of heart and respiratory rates after exercise in the horse. Equine vet. J. 5, 8-14.
2. Art, T., Anderson L., Woakes, A.J., Roberts, C. Butler, P.J., Snow, D.H. and Lekeux, P. (1990) Mechanics of breathing during strenuous exercise in thoroughbred horses. Resp. Physiol. 82, 279-294.
3. Art, T., Duvivier, D.H., Votion, D., Anciaux, N., Vandenput, S., Bayly, W.M. and Lekeux, P. (1998) Does an acute COPD crisis modify the cardio-respiratory and ventilatory adjustments to exercise in horses? J. appl. Physiol. 84, 845-852.
4. Bayly, W.M., Grant, B.D., Breeze, R.G. and Kramer, J.W. (1983) The effects of maximal exercise on acid-base balance and arterial blood gas tensions in thoroughbred horses. In: Equine Exercise Physiology. Eds: D.H. Snow, S.G.B. Persson and R.J. Rose, Granta Editions, Cambridge. pp 400-407.
5. Bayly, W.M., Duvivier, D.H., Votion, D., Vandenput, S., Art, T. and Lekeux, P. (1997) Effect of inhaled ipratropium bromide on pulmonary mechanics and gas exchange during exercise in horses with COPD. In: Proceedings of the 15th Veterinary Respiratory Symposium, Liege, Belgium. p 517.
6. Beaver, W.L., Wasserman, K. and Whipp, B.J. (1973) On-line computer analysis and breath-by-breath graphical display of exercise function tests. J. appl. Physiol. 34, 1958-1966.
7. Buess, C., Pietsch, P., Guggenbühl, W. and Koller, E.A. (1986) A pulsed diagonal beam ultrasonic airflow meter. J. appl. Physiol. 61, 1195-1199.
8. Butler, P.J., Woakes, A.J., Smale, K., Roberts, C.A., Hillidge, C.J., Snow, D.H. and Marlin, D.J. (1993) Respiratory and cardiovascular adjustments during exercise of increasing intensity and during recovery in thoroughbred racehorses. J. expt. Biol. 179, 159-180.
9. Cardinet, G.H., Fowler, M.E. and Tyler, W.S. (1963) Heart rates and respiratory rates for evaluating performances in horses during endurance trail ride competition. J. Am. vet. med. Ass. 143, 1303-1309.
10. Duvivier, D.H., Votion, D., Vandenput, S., Art, T. and Lekeux, P. (1997a) Airway response of horses with COPD to dry powder inhalation of ipratropium bromide. Vet. J. 154, 149-153.
11. Duvivier, D.H., Votion, D., Vandenput, S., Art, T. and Lekeux, P. (1997b) Technical validation of a face mask adapted for dry powder inhalation in the equine species. Equine vet. J. 29, 471-476.
12. Gross, N.J. and Bankwala, Z. (1987) Affects of an anticholinergic bronchodilator on arterial blood gases of hypoxemic patients with chronic obstructive pulmonary disease. Am. Rev. resp. Dis. 136, 1091-1094.
13. Kemp, J.P., Dockorn, RJ., Busse, W.W., Bleecker E.R. and Van As, A. (1994) Prolonged effect of inhaled salmeterol against exercise-induced bronchospasm. Am. J. resp. crit. care Med. 150, 1612-1615.
14. Krzywanek, H. (1988) Lactic acid values in the blood of trotting horses after exercise and the influence of muscular activity during the recovery phase. Berl. Münch. Tierärztl. Woch. 101, 145-149.
15. Kvart, C., Carlsten, J., Dahl, L. and Ryden, L. (1987) Changes in arterial oxygen tension in COPD horses after reduction of exposure to dust in the feed and environment. In: Equine Exercise Physiology 2. Eds: J.R. Gillespie and N.E. Robinson. ICEEP Publications, Davis, California. pp 753-759.
16. Lekeux, P. and Art, T. (1994) The respiratory system: anatomy, physiology, and adaptations to exercise and training. In: Principles and Practice of Equine Sports Medicine: The Athletic Horse. Eds: D.R. Hodgson and R.J. Rose, W.B. Saunders, Philadelphia. pp 79-127.
17. McPherson, E.A., Lawson, G.H.K., Murphy, J.R., Nicholson, J.M., Fraser, J.A., Breeze, R.G. and Pirie, H.M. (1978) Chronic obstructive pulmonary disease (COPD); identification of affected horses. Equine vet. J. 10, 47-53.
18. Mahler, D.A. (1993) Exercise-induced asthma. Med. Sci. Sports and Exerc. 25, 554-561.
19. Nuytten, J., Deprez, P., Picavet, T., Van Den Hende, C. and Muylle, E. (1988) Comparison of different pulmonary function tests and their prognostic value in horses affected with COPD. J. equine vet. Sci. 8, 361-364.
20. Rabe, K.F., Jorres, R. and Magnussen, H. (1993) The effect of 10, 50 and 200 micrograms inhaled fenoterol on exercised-induced asthma. Clin. expt. Allergy. 23, 440-445.
21. Robinson, N.E., Derksen, F.J., Berney, C. and Goossens, L. (1993) The airway response of horses with recurrent airway obstruction (heaves) to aerosol administration of ipratropium bromide. Equine vet. J. 25, 299-303.
22. Rose, R.J., Allen, J.R. and Brock, K.A. (1983) Effects of clenbuterol hydrochloride on certain respiratory and cardiovascular parameters in horses performing treadmill exercise. Res. vet. Sci. 35, 301-305.
23. 2 debt and deficit, and muscle metabolites in thoroughbred horses. J. appl. Physiol. 64, 781-788.
24. Thornton, J., Essen-Gustavsson, B., Lindholm, A., McMiken, D. and Persson, S. (1983) Effects of training and detraining on oxygen uptake, cardiac output, blood gas tensions, pH and lactate concentrations during and after exercise in the horse. In: Equine Exercise Physiology. Eds: D.H. Snow, S.G.B. Persson and R.J. Rose. Granta Editions, Cambridge. pp 470-486.
25. Weiner, N. (1980) Atropine, scopolamine, and related antimuscarinic drugs. In: The Pharmacologic Basis of Therapeutics, 6th edn. Eds: A.G. Gilman and L.S. Goodman, New York, McMillan. pp 120-137.
26. Witherington, D.H. (1971) Observations on the heart rate of Thoroughbreds, Equine vet. J. 3, 99.