Zinc inhibits the in vitro conversion of thyroxine to triiodothyronine in brown adipose tissue;El cinc inhibe la conversion de tiroxina en triiodotironina en grasa parda in vitro

Medicina

Volumn 59, Issue 3, 1999, Pages 265-268

  Pavia Jr , Mario ^b   Paier, Birgit ^b   Hagmüller, Karl ^b   Zaninovich, Angel ^a  

^a HOSPITAL DE CLÍNICAS JOSÉ DE SAN MARTÍN   (Argentina)

^b NONE

Author keywords

Brown adipose tissue; Thyroxine; Triidothyronine

Indexed keywords

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; DITHIOTHREITOL; LIOTHYRONINE; SUCROSE; THYROXINE; ZINC SULFATE;

ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEIODINATION; NONHUMAN; RAT; TEMPERATURE SENSITIVITY; TISSUE HOMOGENATE; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; METABOLISM; TEMPERATURE; WISTAR RAT;

ADIPOSE TISSUE, BROWN; ANIMALS; RATS; RATS, WISTAR; TEMPERATURE; THYROXINE; TRIIODOTHYRONINE; ZINC SULFATE;

EID: 0032615904     PISSN: 00257680     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Nichols DG, Locke RM. Thermogenic mechanism in brown fat. Physiol Rev 1984; 64: 1-64.
2. Himms-Hagen J. Brown adipose tissue thermogenesis: Interdisciplinary studies. FASEB J 1990; 4: 2890-98.
3. Silva JE, Larsen PR. Potential brown adipose tissue type II thyroxine 5′-deiodinase as a local and systemic source of triiodo-thyronine in rats. J Clin Invest 1985; 76: 2296-305.
4. Bianco A, Silva JE. Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. J Clin Invest 1987; 79: 295-300.
5. Cageao LF, Noli MI, Mignone IR, et al. Relative roles of thyroid hormones and noradrenaline on the thermogenic activity of brown adipose tissue in the rat. J Endocrinol 1995; 145: 579-84.
6. Paier B, Pavia MA Jr, Hansi C, Noli MI, Hagmüller K, Zaninovich AA. Cadmium inhibits the in vitro conversion of thyroxine to triidothyronine in rat brown adipose tissue. Environ Contam Toxicol 1997, 59: 164-70.
7. Gonzalez Pondal M, Paier B, Noli MI, Tudino NB, Stripeikis JD, Hagmüller K, Zaninovich AA. Changes induced by zinc on thyroxine deiodination by rat liver in vivo and in vitro. Acta Physiol Pharmacol et Ther Latinoam 1995; 45: 34-41.
8. Ceppi JA, Zaninovich AA. Effects of amiodarone on 5′deiodination of thyroxine to tri-iodothyronine in rat myocardium. J Endocrinol 1989; 121: 431-4.
9. Lowry OH, Rosebrough NJ, Farr AL, Randal RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-75.
10. Rothwell NJ, Stock MJ. Effects of denervating brown adipose tissue on the response to cold, hyperphagia and noradrenaline treatment in the rat. J Physiol 1984; 355: 457-63.
11. Prasad AS. Discovery and importance of zinc in human nutrition. Fed Proc 1984; 43: 2829-34.
12. Vallee B, Falchuk KH. The biochemical basis of zinc physiology. Physiol Rev 1993; 73: 79-119.
13. Aggett PJ, Comerford JG. Zinc an human health. Nutr Rev 1995; 53: 16-22.
14. Vallee BL, Coleman JE, Auld DS. Zinc fingers, zinc clusters, and zinc twists in DNA-binding protein domains. Proc Batl Acad Sci 1991; 88: 999-1003.
15. Licastro F, Mocchenegiani E, Zannotti M, Arena G, Masi M, Fabris N. Zinc affects the metabolism of thyroid hormones in children with Down's syndrome: normalisation of thyroid stimulating and of reverse triiodothyronine plasmic levels by dietary zinc supplementation. Int J Neurosci 1992; 5: 259-68.
16. Anonymous: Essential trace elements and thyroid hormones. Lancet 1992; 39: 1575-6.
17. Wada I, King C. Effect of low zinc intakes on basal metabolic rate, thyroid hormones and protein utilization in adult men. J Nutr 1986; 116: 1045-53.
18. Fosmire GJ. Zinc toxicity. Am J Clin Nutr 1990; 51: 225-7.
19. Bennett DR, Baird CJ, Chan KM, Crookes PF, Bremmer CG, Gottlieb MM, Naritoku WY. Zinc toxicity following massive coin ingestion. Am J Forensic Med Pathol 1997; 18: 148-53.
20. Dean CE, Hargis BM, Hargis PS. Effects of zinc toxicity on thyroid function and histology in broiler chicks. Toxicol Left 1991; 57: 309-18.
21. Sandstead HH. Requirements and toxicity of essential trace element's illustrated by zinc and copper. Am J Clin Nutr 1995; 1 (3 suppl): 621S-624S.
22. Paier B, Hagmüller K, Noli MI, Stiegler C, Zaninovich AA. Changes induced by cadmium administration on thyroxine deiodination and sulfhydryl groups in rat liver. J Endocrinol 1993; 138: 219-24.
23. Pavia MA, Paier B, Noli MI, Hagmüller K, Zaninovich AA. Evidence suggesting that cadmium induces a nonthyroidal illness syndrome in the rat. J Endocrinol 1997; 154: 113-7.
24. Visser TJ, Does-Tobé I, van der Docter R, Hennemann G. Subcellular localization of a rat liver enzyme converting thyroxine to tri-iodothyronine and possible involvement of essential thiol groups. Bichem J 1976, 157: 479-82.
25. Chopra IJ. Sulfhydryl groups and the monodeiodination of thyroxine to triiodothyronine. Science; 199: 904-6.
26. Harris AEC, Fang SL, Hinerfeld L, Braverman LE, Vagenakis AG. The role of sulfhydryl groups on the impaired 3′, 3,5-triiodothyronine generation from thyroxine in the hypothyroid, starved, fetal and neonatal rodent. J Clin Invest 1979; 63: 516-24.
27. Chopra IJ. Alterations in monodeiodination of iodothyronines in the fasting rat: Effects of nonprotein sulfhydryl groups and hypothyroidism. Metabolism 1980; 29: 161-7.
28. Chen MD, Lin PY, Chen PS, Cheg V, Lin WH. Zinc attenuation of GDP binding to brown adipocytes mitochondria in genetically obese (ob/ob) mice. Biol Trace Elem Res 1997; 57: 139-45.
29. Noli MI, Pavia MA Jr., Mignone IR, Brignone JA, Hagmüller K, Zaninovich A. Cadmium chloride prevents the rise in rat brown adipose tissue mitochondrial respiration in response to acute cold stress. Environ Contam Toxicol 1998; 61: 31-7.