Peutz-Jeghers syndrome: Risks of a hereditary condition: A clinical review

Scandinavian Journal of Gastroenterology, Supplement

Volumn 33, Issue 34, 1999, Pages 64-70

  Westerman, A M ^a   Wilson, J H P ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Gastrointestinal polyposis; Gonadal tumours; Hamartomas; Hereditary cancer; Mucocutaneous pigmentation; Peutz Jeghers syndrome; Sex cord tumours

Indexed keywords

MELANIN; PROTEIN SERINE THREONINE KINASE; STK11 PROTEIN, HUMAN;

ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CANCER RISK; CLINICAL FEATURE; DISEASE COURSE; GASTROINTESTINAL ENDOSCOPY; GASTROINTESTINAL HEMORRHAGE; HETEROZYGOTE; HUMAN; INTESTINE INTUSSUSCEPTION; INTESTINE RADIOGRAPHY; LAPAROTOMY; PEUTZ JEGHERS SYNDROME; PHENOTYPE; POLYPECTOMY; PRIORITY JOURNAL; RISK; TUMOR SUPPRESSOR GENE; DIFFERENTIAL DIAGNOSIS; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MUTATION; REVIEW; RISK FACTOR;

DIAGNOSIS, DIFFERENTIAL; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HUMANS; PEUTZ-JEGHERS SYNDROME; PROTEIN-SERINE-THREONINE KINASES; RISK FACTORS;

EID: 0032610848     PISSN: 00855928     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Peutz JLA. Over een zeer merkwaardige, gecombineerde familiaire polyposis van de slijmvliezen van den tractus intestinalis met die van de neuskeelholte en gepaard met eigenaardige pigmentaties van huid- en slijmvliezen. Ned Maandschr v Gen 1921;10:134-46.
2. Hutchinson J. Pigmentation of lips and mouth. Arch Surg 1896;7:290.
3. Connor JT. Lancet 1895;2:1169.
4. Weber FP. Patches of deep pigmentation of oral mucous membrane not connected with Addison's disease. Quart J Med 1919;12:404-8.
5. Jeghers H, McKusick VA, Katz KH. Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits: a syndrome of diagnostic significance. N Engl J Med 1949; 241:993-1005, 1031-6.
6. Van Dijk JA, Oudendal AJF. Adenoom van den dunnen darm. Ned Tijdschr v Gen 1925;I:965-73.
7. Jeghers H. Pigmentation of skin. N Engl J Med 1944;231:88-100, 122-36, 181-9.
8. Bruwer A, Bargen JA, Kierland RR. Surface pigmentation and generalized intestinal polyposis (Peutz-Jeghers syndrome). Proceedings of the Staff Meetings of the Mayo Clinic 1954; 29:168-71.
9. Bartholomew LG, Moore CE, Dahlin DC, Waugh JM. Intestinal polyposis associated with mucocutaneous pigmentation. Surg Gynecol Obstet 1962;115:1-11.
10. Matuchansky C, Babin P, Coutrot S, et al. Peutz-Jeghers syndrome with metastasizing carcinoma arising from a jejunal hamartoma. Gastroenterol 1979;77:1311-5.
11. Dozois RR, Judd ES, Dahlin DC, Bartholomew LG. The Peutz-Jeghers syndrome. Is there a predisposition to the development of intestinal malignancy? Arch Surg 1969;98:509-16.
12. Cannon PG, Dahlin DC, Bartholomew LG. Polypoid glandular tumors of the small intestine. Surg Gynecol Obstet 1962;8:666-72.
13. Joishy SK, Leela MP, Balasegaram M. Peutz-Jeghers syndrome and its complications. Am J Surg 1979;138:716-20.
14. Morens DM, Garvey SP. An unusual case of Peutz-Jeghers syndrome in an infant. Am J Dis Child 1975;129:973-6.
15. McAllister AJ, Richards KF. Peutz-Jeghers syndrome with twenty patients in five generations. Am J Surg 1977;134:717-20.
16. Bartholomew LG, Dahlin DC, Waugh JM. Intestinal polyposis associated with mucocutaneous melanin pigmentation (Peutz-Jeghers syndrome). Gastroenterol 1957;32:434-51.
17. Bowlby LS. Pancreatic adenocarcinoma in an adolescent male with Peutz-Jeghers syndrome. Hum Pathol 1986;17:97-9.
18. McKittrick JE, Lewis WM, Doane W, Gerwig WH. The Peutz-Jeghers syndrome. Report of two cases, one with 30-year follow-up. Arch Surg 1971;103:57-62.
19. Westerman AM, van Velthuysen MLF, Bac DJ, Scheuten WR, Wilson JHP. Malignancy in Peutz-Jeghers syndrome? The pitfall of pseudo-invasion. J Clin Gastroenterol 1997;25:387-90.