Coagulation protein function: The influence of acetaldehyde-modified heparin on thrombin activity

Journal of Investigative Medicine

Volumn 47, Issue 1, 1999, Pages 76-80

  Brecher, Arthur S ^a   Fu, Q ^a  

^a BOWLING GREEN STATE UNIVERSITY   (United States)

Author keywords

Acetaldehyde; Alcoholism; Blood coagulation; Heparin; Thrombin

Indexed keywords

ACETALDEHYDE; HEPARIN; THROMBIN;

ALCOHOLISM; ANIMAL; ARTICLE; BLOOD; CATTLE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; IN VITRO STUDY; THROMBIN TIME;

ACETALDEHYDE; ALCOHOLISM; ANIMALS; CATTLE; HEPARIN; HUMANS; THROMBIN; THROMBIN TIME;

EID: 0032608980     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Iber FL, Shamszad M, Miller PA, Jacob R. Vitamin K deficiency in chronic alcoholic males. Alcohol Clin Exp Res 1986;10:679-81.
2. Boyer TD. Cirrhosis of the liver. In: Wyngaarden JB, Smith LH, eds. Cecil textbook of medicine. Philadelphia: Saunders, 1985:835-45.
3. Podolsky DK, Isselbacher KJ. Cirrhosis. In: Braunwald E, Isselbacher KJ, Petersdorf RG, Wilson JD, Martin JB, Sauci AS, eds. Harrison's Principles of Internal Medicine: 12th ed. New York: McGraw-Hill, Inc., 1991:1341-51.
4. Crabb DW, Lumeng L. Alcoholic liver diseases. In: Kelly WN, ed. Textbook of internal medicine. Philadelphia: Lippincott. 1989:592-602.
5. Basista MH, Joseph A, Smolen S, Koterba A, Brecher AS. Acetaldehyde alters coagulation protein function. Dig Dis Sci 1994;39:2421-5.
6. Brecher AS, Koterba AP, Basista MH. Coagulation protein function. III. Effect of acetaldehyde upon the activation of prothrombin. Alcohol 1996;13:423-9.
7. Brecher AS, Koterba AP, Basista MH. Coagulation protein function IV. Effect of acetaldehyde upon factor X and factor Xa, the proteins at the gateway to the common coagulation pathway. Alcohol 1996;13:539-45.
8. Haider SKB, Kleshinski J, Brecher A, Basista MH. The direct effect of acetaldehyde on the function of clotting factors VII, IX, and XI [abstract]. Am Assn Study Liver Dis Annual Meeting, Chicago, IL, 1996.
9. Brecher AS, Hellman K, Basista MH. Coagulation protein function VI. Augmentation of anticoagulant function by acetaldhyde-treated heparin. Dig Dis Sci 1998. In press.
10. Brecher AS, Adamu MT. Anticoagulant activity of acetaldehyde-treated glycosaminoglycans [abstract]. J Investig Med 1998:210A.
11. Li EHH, Orton C, Feinman RD. The interaction of thrombin and heparin. Proflavin dye binding studies. Biochemistry 1974;13:5012-7.
12. Rosenberg RD. The role of heparin and heparin-like molecules in thrombosis and atherosclerosis. FASEB J 1985;44:404-9.
13. Koterba AP, Smolen S, Joseph A, Basista MH, Brecher AS. Coagulation protein function. II. Influence of thiols upon acetaldehyde effects. Alcohol 1995;12:49-57.
14. Fraenkel-Conrat H, Olcott HS. The reaction of formaldehyde with proteins IV. Cross-linking between amino and primary amide or guanidyl groups. J Am Chem Soc 1948;70:2673-84.
15. Fraenkel-Conrat H, Olcott HS. Reaction of formaldehyde with proteins. VI. Cross-linking of amino groups with phenol, imidazole, or indole groups. J Biol Chem 1948;174:827-43.
16. Fraenkel-Conrat H, Brandon BA, Olcott HS. The reaction of formaldehyde with proteins. IV. Participation of indole groups. Gramicidin. J Biol Chem 1947;168:99-118.
17. Ratner S, Clarke HT. The action of formaldehyde upon cysteine. J Am Chem Soc 1937;59:200-6.
18. Hatake K, Taniguchi T, Ouchi H, Sakaki N, Hishida S, Ijiri I. Possible involvement of kinins in cardiovascular changes after alcohol intake. Pharmacol Biochem Behav 1990;35:437-42.
19. Salaspuro M. Epidemiological aspects of alcohol and alcoholic liver disease, ethanol metabolism, and pathogenesis of alcoholic liver injury. In: Seitz HK, Kommerell B, eds. Oxford textbook of clinical hepatology. Heidelberg: Springer-Verlag, 1985:376-414.
20. Henriques V, Sorensen SPL. The quantitative estimation of amino acids, polypeptides and hippuric acid in urine by titration with formaldehyde. II. Z Physiol Chem 1909;64:120-143.
21. Brecher AS. Clotting system, In: Roitt IM, Delves PJ, eds. Encyclopedia of immunology: 2nd ed. London: Academic Press Ltd., 1998:78-86.
22. Watanabe A, Kobayashi M, Hobare M, Nakatsukasa H, Nagashima H, Fujimoto A. A report of unusually high blood ethanol and acetaldehyde levels in two surviving patients. Alcohol Clin Exp Res 1985;9:14-6.
23. Israel Y, Hurwitz E, Niemola O, Arnon R. Monoclonal and polyclonal antibodies against acetaldehyde-containing epitopes in acetaldehyde-protein adducts. Proc Natl Acad Sci US 1986;83:7923-7.
24. Worrall S, DeJersey J, Shanley BC, Wilce PA. Anti-acetaldehyde adduct antibodies generated by ethanol-fed rats react with reduced and unreduced acetaldehyde-modified proteins, Alcohol Alcohol 1994;29:43-50.