Cortical brain dysfunction in early schizophrenia: Secondary pathogenetic hierarchy of neuroplasticity, psychopathology and social impairment

Acta Psychiatrica Scandinavica, Supplement

Volumn 99, Issue 395, 1999, Pages 80-88

  Hemmingsen, Ralf ^a   Madsen, A ^a   Glenthoj B ^a   Rubin, P ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Cortex; Neuronal network; Neuroplasticity; Pathogenesis; Schizophrenia; Secondary causation

Indexed keywords

BRAIN DYSFUNCTION; BRAIN SIZE; CELL DENSITY; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; FRONTAL LOBE; HALLUCINATION; HUMAN; NERVE CELL NETWORK; NERVE CELL PLASTICITY; PATHOGENESIS; PERCEPTION; PREFRONTAL CORTEX; RECALL; SCHIZOPHRENIA; SOCIAL ADAPTATION; SPEECH; TEMPORAL LOBE; THALAMUS; ARTICLE; BIOLOGICAL MODEL; BRAIN CORTEX; COGNITION; COGNITIVE DEFECT; CONSCIOUSNESS; DISEASE COURSE; DISEASE PREDISPOSITION; GROWTH, DEVELOPMENT AND AGING; MEMORY; NERVE TRACT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; SOCIAL ISOLATION;

DOPAMINE;

CEREBRAL CORTEX; COGNITION DISORDERS; CONSCIOUSNESS; DISEASE PROGRESSION; DISEASE SUSCEPTIBILITY; DOPAMINE; HUMANS; MEMORY; MODELS, NEUROLOGICAL; NERVE NET; NEURAL PATHWAYS; NEUROBEHAVIORAL MANIFESTATIONS; NEURONAL PLASTICITY; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SOCIAL ALIENATION; THALAMUS;

EID: 0032608905     PISSN: 00651591     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0447.1999.tb05986.x     Document Type: Conference Paper

References (42)

1. BLANKENBURG W. Der Verlust der natürlichen Selbstverständlichkeit. Ein beitrag zur Psychopathologie symptomarmer Schizophrenien. Stuttgart: Enke, 1971.
2. CHALMERS D. Facing up to the problem of consciousness. J Conscious Studies 1995;2:200-219.
3. PHELPS ME, BARRIO JR, HOFFMANN EJ, HUANG SCH, CHUGANI HT. PET: a biochemical image of the brain at work. In: LASSEN NA, INGVAR DH, RAICHLE ME, FRIBERG L, ed. Alfred Benzon Symposium 31. Brain work and mental activity. Copenhagen: Munksgaard, 1991:32-40.
4. HUTTENLOCHER PR. Synaptic density in human frontal cortex - developmental changes and effects of aging. Brain Res 1979;163:195-205.
5. SOKOLOFF L. Circulation and energy metabolism of the brain. In: SIEGEL GJ, AGRANOFF BW, ALBERS RW, MOLINOFF PB, ed. Basic neurochemistry; molecular, cellular and medical aspects. New York: Raven Press, 1989:565-590.
6. DAMASIO AR. Synchronous activation in multiple cortical regions: a mechanism for recall. Semin Neurosci 1990;2:287-296.
7. RUBIN P, KARLE A, MØLLER-MADSEN S et al. CT scan in newly diagnosed schizophrenia and schizophreniform disorder: a controlled blind study. Br J Psychiatry 1993;163:604-612.
8. RUBIN P, HOLM S, MADSEN PL et al. rCBF distribution in newly diagnosed schizophrenia and schizophreniform disorder: a SPECT study. Psychiatry Res: Neuroimaging 1994;53:57-75.
9. RUBIN P, VORSTRUP S, HEMMINGSEN R et al. Neurological abnormalities in patients with schizophrenia or schizophreniform disorder at first admission to hospital: correlations with computerized tomography and regional cerebral blood flow findings. Acta Psychiatr Scand 1994;90:385-390.
10. RUBIN P, HOLM A, MØLLER-MADSEN S et al. Neuropsychological deficit in newly diagnosed patients with schizophrenia or schizophreniform disorder. Acta Psychiatr Scand 1995;92:35-43.
11. RUBIN P. Neurobiological findings in first-admission patients with schizophrenia or schizophreniform disorder. Dan Med Bull 1997;44:140-154.
12. HÄFNER H, NOWOTNY B, LÖFFLER W, HEIDEN W, MAURER K. When and how does schizophrenia produce social deficits?. Arch Psychiatry Clin Neurosci 1995;246: 17-28.
13. PARNAS J, JØRGENSEN Å. Premorbid psychopathology in schizophrenia spectrum. Br J Psychiatry 1989;155:623-627.
14. CANNON TD, MEDNICK SA. The schizophrenia high-risk project in Copenhagen: three decades of progress. Acta Psychiatr Scand 1993;Suppl. 370:33-47.
15. WALKER EF, GRIMES KE, DAVIS DM, SMITH AJ. Childhood precursors of schizophrenia: facial expression of emotion. Am J Psychiatry 1993;150:1654-1660.
16. HOLLIS C. Child and adolescent (juvenile onset) schizophrenia: a case control study of premorbid developmental impairments. Br P Psychiatry 1995;166:489-495.
17. DAVIS JO, PHELPS JA, BRACHA HS. Prenatal development of monozygotic twins and concordance for schizophrenia. Schizophr Bull 1995;21:357-366.
18. HEMMINGSEN R, GLENTHØJ B, RUBIN P. Malattunement of the cortical network in schizophrenia: association of psychopathology and neurobiology. Alfred Benzon Symposium No. 38. In: FOG R, GERLACH J, HEMMINGSEN R, ed. Schizophrenia: an integrated view. Copenhagen: Munksgaard, 1995:60-70.
19. PAKKENBERG B. Total nerve cell number in neocortex in chronic schizophrenics and controls estimated using optical disectors. Biol Psychiatry 1993;34:768-772.
20. SELEMON LD, RAJKOWSKA G, GOLDMAN-RAKIC PS. Abnormally high neuronal density in the schizophrenic cortex. Arch Gen Psychiatry 1995;52:805-818.
21. KESHAVAN MS, ANDERSON S, PETTIGREW JW. Is schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited. J Psychiatr Res 1994;28:239-265.
22. MCGUIRE PK, FRITH CD. Disordered functional connectivity in schizophrenia (editorial). Psychol Med 1996;26:663-667.
23. SIEGEL BV, BUCHSBAUM MS, BUNNEY WE et al. Cortical-striatal-thalamic circuits and brain glucose metabolic activity in 70 unmedicated male schizophrenia patients. Am J Psychiatry 1993;150:1325-1336.
24. INGVAR DH, FRANZEN G. Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatr Scand 1974;50:425-462.
25. LEVY DL, SMITH M, ROBINSON D et al. Methylphenidate increases thought disorder in recent-onset schizophrenics, but not in normal controls. Biol Psychiatry 1993;34:507-514.
26. FRITH CD, FRISTON KJ, HEROLD S et al. Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task. Br J Psychiatry 1995;167:343-349.
27. MCGUIRE PK, SILBERSWEIG DA, WRIGHT I, MURRAY RM, FRACKOWIAK RSJ, FRITH CD. The neural correlates of inner speech and auditory verbal imagery in schizophrenia: relationship to auditory verbal hallucinations. Br J Psychiatry 1996;169:148-159.
28. YURGELUN-TODD DA, WATERNAUX CM, COHEN BM, GRUBER SA, ENGLISH CD, RENSHAW PF. Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during word production. Am J Psychiatry 1996;153:200-205.
29. SILBERSWEIG DA, STERN E, FRITH CD. The functional neuroanatomy of hallucinations in schizophrenia. Nature 1995;378:176-179.
30. HOFFMAN RE, RAPAPORT J, AMELI R, MCGLASHAN TH, HARCHERIK D. A neuronal network simulation of hallucinated 'voices' and associated speech perception impairments in schizophrenic patients. J Cogn Neurosci 1995;7:479-496.
31. AGGERNÆS A. Reality testing in schizophrenia. Nord J Psychiatry 1994;48(Suppl. 31):47-54.
32. MORRISON-STEWART SL, VELIKONJA D, CORNING WC, WILLIAMSON P. Aberrant interhemispheric alpha coherence on electroencephalography in schizophrenic patients during activation tasks. Psychol Med 1996;26:605-612.
33. MALLA AK, NORMAN RMG, AGUILAR O, CARNAHAN H, CORTESE L. Relationship between movement planning and psychopathology profiles in schizophrenia. Br J Psychiatry 1995;167:211-215.
34. CARLSSON A. The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 1988;1:179-186.
35. PAKKENBERG B. Pronounced reduction of nerve cell number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics. Arch Gen Psychiatry 1990;47:1023-1028.
36. ANDREASEN NC, ARNDT S, SWAYZE V et al. Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging. Science 1994;266:294-298.
37. BUCHSBAUM MS, SOMEYA T, TENG CY et al. PET and MRI of the thalamus in never-medicated patients with schizophrenia. Am J Psychiatry 1996;153:191-199.
38. BLENNOW K, DAVIDSSON P, GOTTFRIES CG, EKMAN R, HEILIG M. Synaptic degeneration in thalamus in schizophrenia. Lancet 1996;348:692-693.
39. FEINBERG I. Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence? J Psychiatry Res 1982;17:319-330.
40. SESTOFT D. Schizophrenic remand prisoners: psychiatric history, social background and criminality. Copenhagen: Schultz, 1997:1-133 (with English summary).
41. GLENTHØJ B, MOGENSEN J, LAUERSEN H, HOLM S, HEMMINGSEN R. Electrical sensitization of the meso-limbic dopaminergic system in rats: a pathogenetic model for schizophrenia. Brain Res 1993;619:39-54.
42. MADSEN AL, KEIDING N, KARLE A, ESBJERG S, HEMMINGSEN R. Neuroleptics in progressive structural brain abnormalities in psychiatric illness. Lancet 1998;352:784-785.