Cellular and molecular mechanisms responsible for the pathogenesis of primary pulmonary hypertension

Pediatric Pulmonology

Volumn 27, Issue SUPPL. 18, 1999, Pages 194-197

  Rubin, Lewis J ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOREX; ENDOTHELIN; FENFLURAMINE; POTASSIUM CHANNEL; PROSTACYCLIN; SEROTONIN; THROMBOXANE; VASCULOTROPIN; ION CHANNEL;

ARTERY INTIMA PROLIFERATION; BLOOD VESSEL TONE; CONFERENCE PAPER; GENETIC SUSCEPTIBILITY; HUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RISK FACTOR; ANIMAL; DISEASE PREDISPOSITION; LUNG CIRCULATION; PHYSIOLOGY; REVIEW; VASCULAR ENDOTHELIUM; VASOCONSTRICTION;

ANIMALS; DISEASE SUSCEPTIBILITY; ENDOTHELIUM, VASCULAR; HUMANS; HYPERTENSION, PULMONARY; ION CHANNELS; PULMONARY CIRCULATION; VASOCONSTRICTION;

EID: 0032604835     PISSN: 87556863     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-0496(1999)27:18+<194::AID-PPUL63>3.0.CO;2-6     Document Type: Conference Paper

References (16)

1. Rubin LJ. Primary pulmonary hypertension. N Engl J Med. 1997; 336:111-117.
2. Brenot F, Simonneau G. Risk Factors. In: Rubin LJ, Rich S, eds. Primary Pulmonary Hypertension. Marcel Dekker, 1997, 131-149.
3. Nichols WC, Koller DL, Slovis B. Localization of the gene for familial primary pulmonary hypertension to chromosome 2q3 1-32. Nature Genet. 1997; 15:277-280.
4. Herve P, Lannay JM, Scrobohaci ML, Brenot F, Simonneau G, Petitpretz P, Poubeau P, Cerrina J, Duroux P, Drouet L. Increased plasma serotonin in primary pulmonary hypertension. Am J Med. 1995; 99:249-254.
5. Herve P, Drouet L, Dosquet C, Launay JM, Rain B, Simonneau G, Caen J, Duroux P. Primary pulmonary hypertension in a patient with a familial platelet storage pool disease: Role of serotonin. Am J Med. 1990; 89:117-120.
6. Weir EK, Rubin LJ, Ayres SM, Bergofsky EH, Brandage BH, Detre KM, Elliott CG, Fishman AP, Goldring RM, Groves BM, Kernis JT, Koerner SK, Levy PS, Pietra GG, Reid LM, Rich S, Vreim CE, Williams GW, Wu M. The acute administration of vasodilators in primary pulmonary hypertension. Am Rev Respir Dis. 1989; 140:1623-1630.
7. Christman BW, McPherson CD, Newman JH. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N Engl J Med. 1992; 327:70-75.
8. Stewart DJ, Levy RD, Cernacek P, Langleben D. Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease? Ann Intern Med. 1991; 114:467-469.
9. Dinh-Xuan A, Higenbottam T, Clelland M. Impairment of endothelium-dependent pulmonary artery relaxation in obstructive lung disease. N Engl J Med. 1991; 324:1539-1547.
10. Giaid A, Saleh D. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med. 1995; 333:214-221.
11. Giaid A, Yanagisawa M, Langleben D, Michel RP, Levy R, Shennib A, Kimura S, Masaki D, Duguid WP, Stewart DJ. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med. 1993; 328:173-176.
12. Tuder RM. Plexiform lesions in primary pulmonary hypertension may represent an abnormal form of angiogenesis. Semin Respir Crit Care Med. 1994; 15:207-214.
13. Yuan XY, Tod ML, Rubin LJ, Blaustein MP. Hypoxic and metabolic regulation of voltage-gated K+ channels in rat pulmonary artery smooth muscle. Exp Physiol. 1995; 80:803-813.
14. Yuan XJ, Wang J, Juhaszova N, Gaine SP, Rubin LJ. Attenuated K+ channel gene transcription in primary pulmonary hypertension. Lancet. 1998; 351:726-727.
15. Yuan XJ, Aldinger AM, Orens JB, Conte JV, Rubin LJ. Dysfunctional voltage-gated potassium channels in pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension. Circulation. 1998; in press.
16. Weir EK, Reeve HL, Huang JMC, Michelakis E, Nelson DP, Hampl V, Archer SL. Anorexic agents aminorex, fenfluramine and dexfenfluramine inhibit potassium current in rat pulmonary artery vascular smooth muscle and cause pulmonary vasoconstriction. Circulation. 1996; 94:2216-2220.