Detoxication of paraoxon by rat liver homogenate and serum carboxylesterases and A-esterases

Journal of Biochemical and Molecular Toxicology

Volumn 13, Issue 5, 1999, Pages 261-268

  Tang, Jun ^a   Chambers, Janice E ^a  

^a MISSISSIPPI STATE UNIVERSITY   (United States)

Author keywords

A Esterase; Aliesterase; Carboxylesterase; Paraoxon

Indexed keywords

ACETYLCHOLINESTERASE; ARYLESTERASE; CARBOXYLESTERASE; INSECTICIDE; PARAOXON; PARATHION;

ANIMAL; ARTICLE; BLOOD; BRAIN; DRUG ANTAGONISM; DRUG DETOXIFICATION; DRUG EFFECT; ENZYMOLOGY; IN VITRO STUDY; LIVER; MALE; METABOLISM; PHOSPHORYLATION; RAT; SPRAGUE DAWLEY RAT;

ACETYLCHOLINESTERASE; ANIMALS; BRAIN; CARBOXYLESTERASE; CARBOXYLIC ESTER HYDROLASES; INSECTICIDES; LIVER; MALE; METABOLIC DETOXICATION, DRUG; PARAOXON; PARATHION; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032604096     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-0461(1999)13:5<261::AID-JBT6>3.0.CO;2-0     Document Type: Article

References (10)

1. Gaines TB. The acute toxicity of pesticides to rats. Toxicol Appl Pharmacol 1960; 2:88-99.
2. Diggle WM, Gage JC. Cholinesterase inhibition in vitro by O,O-diethyl O-p-nitrophenyl thiophosphate (parathion, E605). Biochem J 1951; 49:491-494.
3. Gage JC. A cholinesterase inhibitor derived from O,O-diethyl O-p-nitrophenyl thiophosphate HI vivo. Biochem J 1953; 54:426-430.
4. Neal RA. Microsomal metabolism of the thiono-sulfur compounds: mechanisms and toxicological significance. In: Hodgson E, Bend JR, Philpot RM, editors. Review in biochemical toxicology. Volume 2. New York: Elsevier North Holland; 1980; p. 131-171.
5. Lauwerys RR, Murphy SD. Interaction between paraoxon and tri-o-tolyl phosphate in rats. Toxicol Appl Pharmacol 1969; 14:348-357.
6. Chambers H, Brown B, Chambers JE. Noncatalytic detoxication of six organophosphorus compounds by rat liver homogenates. Pestic Biochem Physiol 1990; 36:308-315.
7. Chambers JE, Chambers HW. Time course of inhibition of acetylcholinesterase and aliesterases following parathion and paraoxon exposures in rats. Toxicol Appl Pharmacol 1990; 103:420-429.
8. Maxwell DM. The specificity of carboxylesterase protecting against the toxicity of organophosphorus compounds. Toxicol Appl Pharmacol 1992; 114:306-312.
9. Chanda SM, Mortensen SR, Moser VC, Padilla S. Tissuespecific effects of chlorpyrifos on carboxylesterase and cholinesterase activity in adult rats: an in vitro and in vivo comparison. Fundam Appl Toxicol 1997; 38: 148-157.
10. Lauwerys RR, Murphy SD. Comparison of assay methods for studying O,O-diethyl, O-p-nitrophenyl phosphate (paraoxon) detoxication in vitro. Biochem Pharmacol 1969; 18: 789-800.