Design and characterization of gramicidin channels with side chain or backbone mutations

Novartis Foundation Symposium

Volumn 225, Issue , 1999, Pages 44-61

  Koeppe II, Roger E ^b   Greathouse, Denise V ^b   Providence, Lyndon L ^a   Shobana, S ^a   Andersen, Olaf S ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF ARKANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; GRAMICIDIN; ION CHANNEL;

AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; MOLECULAR GENETICS; MUTATION; PROTEIN SECONDARY STRUCTURE; REVIEW;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; DRUG DESIGN; GRAMICIDIN; ION CHANNELS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, SECONDARY;

EID: 0032601774     PISSN: None     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (7)

1. Andersen OS 1983 Ion movement through gramicidin A channels. Single-channel measurements at very high potentials. Biophys J 41:119-133
2. Andersen OS, Koeppe RE II 1992 Molecular determinants of channel function. Physiol Rev 72:S89-S158
3. Andersen OS, Greathouse DV, Providence LL, Becker MD, Koeppe RE II 1998 Importance of tryptophan dipoles for protein function: 5-fluorination of tryptophans in gramicidin A channels. J Am Chem Soc 120:5142-5146
4. Arseniev AS, Lomize AL, Barsukov IL, Bystrov VF 1986 Gramicidin A transmembrane ion-channel. Three-dimensional structure reconstruction based on NMR spectroscopy and energy refinement. Biol Membr (USSR) 3:1077-1104
5. Bamberg E, Apell HJ, Alpes HJ 1977 Structure of the gramicidin A channel: discrimination between the π-L,D and the beta-helix by electrical measurements with lipid bilayer membranes. Proc Natl Acad Sci USA 74:2402-2406
6. Becker MD, Greathouse DV, Koeppe RE II, Andersen OS 1991 Amino acid sequence modulation of gramicidin channel function: effects of tryptophan-to-phenylalanine substitutions on the single-channel conductance and duration. Biochemistry 30:8830-8839
7. Burkhart BM, Li N, Langs DA, Pangborn WA, Duax WL 1998 The conducting form of gramicidin A is a right-handed double-stranded double helix. Proc Natl Acad Sci USA 95:12950-12955