Production of [13N]NH3 with ultra-high specific activity

Applied Radiation and Isotopes

Volumn 50, Issue 3, 1999, Pages 497-503

  Suzuki, K ^a,b   Yoshida, Y ^a,c  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c Sumitomo Accelerator Service   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALLOY; AMMONIA; HYDROGEN; NITROGEN 13; OXYGEN; TITANIUM DERIVATIVE;

AQUEOUS SOLUTION; ARTICLE; ION PAIR CHROMATOGRAPHY; IRRADIATION; METHODOLOGY; PRIORITY JOURNAL;

CHROMATOGRAPHY; RADIOACTIVITY MEASUREMENT; SOLUTIONS; SYNTHESIS (CHEMICAL);

RADIO-IONCHROMATOGRAPHY; RADIOCHEMISTRY;

AMMONIA;

EID: 0032599742     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8043(98)00095-5     Document Type: Article

References (28)

1. 13N ]ammonia: Target design, products, and operating parameters Appl. Radiat. Isot. 44:1993;1433-1441.
2. 13N ]ammonia produced by using ethanol as a scavenger J. Label. Comp. Radiopharm. 37:1994;334-336.
3. Cooper A. L., Sheu K. F., Blass J. P. Normal glutamate metabolism in Alzheimer's disease fibroblasts deficient in alpha-ketoglutarate dehydrogenase complex activity. Developmental Neuroscience. 18:1996;499-504.
4. Conlon K. C., Bading J. R., Diresta G. R., Corbally M. T., Gelbard A. S., Brennan M. F. Validation of transport measurements in skeletal muscle with N-13 amino acids using a rabbit isolated hindlimb model. Life Sciences. 44:1989;847-859.
5. 16O target. Appl. Radiat. Isot. 42, 793 - 796.
6. 13N -glutamate J. Radioanal. Nucl. Chem. Letters. 155:1991;9-13.
7. 3 J. Labeled Comp. Radiopharm. 18:1981;244-246.
8. 13N -labeled adenosine and nicotinamide by ammonolysis Int. J. Appl. Radiat. Isot. 36:1985;345-347.
9. 13N ]glutamate in the normal human heart and in patients with coronary artery disease Eur. J. Nucl. Med. 7:1982;211-215.
10. Knapp W. H., Panzer M., Helus F., Layer K., Sinn H.-J., Ostertag H. Effect of methotrexate on perfusion and nitrogen-13 glutamate uptake in the Walker-256 carcinosarcoma. J. Nucl. Med. 29:1988;208-216.
11. 3 Radiokhimiya. 34:1992;70-76.
12. 3 upon irradiation of water and dilute aqueous solutions of ethanol under a pressure of various gases Radiokhimiya. 37:1995;369-373.
13. 13N reaction J. Nucl. Med. 14:1973;629-630.
14. 13N -labeled r-amino-butyric acid J. Label. Comp. Radiopharm. 23:1986;1114-1115.
15. Merck and Co. (1987) The Merck manual of diagnosis and therapy. Merck, Sharp and Dohme Research Laboratories, Rahway, NJ.
16. 18F ]fluoride ion by 26 MeV proton irradiation of a double chamber water target Appl. Radiat. Isot. 41:1990;1193-1199.
17. 13N labeled ammonia, dinitrogen, nitrite, and nitrate using a single cyclotron target system Int. J. Appl. Radiat. Isot. 29:1978;754-756.
18. 13N reaction using an ultra pure water target saturated with gases J. Label. Comp. Radiopharm. 37:1995;761-763.
19. 13N ]ammonia J. Label. Comp. Radiopharm. 37:1995;644-646.
20. 3 and L-(N-13) glutamate ready for intravenous injection Int. J. Appl. Radiat. Isot. 35:1984;771-777.
21. 13N species formed by proton irradiation of water Radiat. Res. 79:1979;22-33.
22. 13N -labeled amides Appl. Radiat. Isot. 37:1986;1209-1212.
23. 13N -labeling Appl. Radiat. Isot. 38:1987;437-445.
24. 13N-labeled ammonia. Int. J. Appl. Radiat. Isot. 26, 316 - 318.
25. 13N -labeled L-tyrosine Acta Radiol. Suppl. 376:1991;110-111.
26. 13N ]ammonia via proton irradiation of dilute aqueous ethanol and acetic acid mixtures Appl. Radiat. Isot. 42:1991;1095-1098.
27. Wu H. M., Hoh C. K., Buxton D. B., Kuhle W. G., Schelbert H. R., Choi Y., Hawkins R. A., Phelps M. E., Huang S. C. Quantification of myocardial blood flow using dynamic nitrogen-13-ammonia PET studies and factor analysis of dynamic structures. J. Nucl. Med. 36:1995;2087-2093.
28. Yoshida K., Mullani N., Gould K. L. Coronary flow and flow reserve by PET simplified for clinical applications using rubidium-82 or nitrogen-13-ammonia. J. Nucl. Med. 37:1996;1701-1712.