Similar localisation of α1- and β-adrenoceptors in rabbit heart in relation to sympathetic nerve endings

European Journal of Pharmacology

Volumn 381, Issue 2-3, 1999, Pages 135-140

  Dybvik, Terje ^a   Osnes, Jan Bjørn ^a   Skomedal, Tor ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

1 Adrenoceptor; Adrenoceptor; (Rabbit); Localisation; Myocardium; Noradrenaline; Uptake blockade

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; COCAINE; HYDROCORTISONE; NORADRENALIN; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ANTIINFLAMMATORY AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DOPAMINE UPTAKE INHIBITOR;

ANIMAL TISSUE; ARTICLE; DOSE RESPONSE; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RABBIT; SYMPATHETIC NERVE; TISSUE DISTRIBUTION; ADRENERGIC SYSTEM; ANIMAL; DRUG EFFECT; HEART; HEART CONTRACTION; HEART PAPILLARY MUSCLE; IN VITRO STUDY; INNERVATION; METABOLISM; SYNAPSE;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC BETA-AGONISTS; ANIMALS; ANTI-INFLAMMATORY AGENTS; COCAINE; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART; HYDROCORTISONE; MYOCARDIAL CONTRACTION; NERVE ENDINGS; NOREPINEPHRINE; PAPILLARY MUSCLES; RABBITS; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, BETA; SYMPATHETIC NERVOUS SYSTEM; SYNAPSES;

EID: 0032589584     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00568-3     Document Type: Article

References (31)

1. Aass, H., 1989. α- and β-adrenergic regulation of cardiac contraction and relaxation. Some physiological and pharmacological aspects. Thesis, University of Oslo, Norway.
2. Aass H., Skomedal T., Osnes J.-B. Demonstration of an α-adrenoceptor-mediated inotropic effect of norepinephrine in rabbit papillary muscles. J. Pharmacol. Exp. Ther. 226:1983;572-578.
3. Aass H., Skomedal T., Osnes J.-B., Fjeld N.B., Klingen G., Langslet A., Svennevig J., Semb G. Noradrenaline evokes an α-adrenoceptor-mediated inotropic effect in human ventricular myocardium. Acta Pharmacol. Toxicol. 58:1986;88-90.
4. Ariëns E.J., Simonis A.M., van Rossum J.M. Drug-receptor interactions: interaction of one or more drugs with one receptor system. Ariëns E.J. Molecular Pharmacology. 1:1964;119-286 Academic Press, New York.
5. Benfey B.G. Functions of myocardial α-adrenoceptors. J. Auton. Pharmacol. 13:1993;351-372.
6. Bennet M.R., Rogers D.C. A Study of the innervation of the Taenia coli. J. Cell Biol. 33:1967;573-596.
7. Bevan J.A., Verity M.A. Sympathetic nerve-free vasculature muscle. J. Pharmacol. Exp. Ther. 175:1967;117-124.
8. Böhm M., Diet F., Feiler G., Kemkes B., Erdmann E. α-Adrenoceptors and α-adrenoceptor-mediated positive inotropic effects in failing human myocardium. J. Cardiovasc. Pharmacol. 12:1988;357-364.
9. 1-adrenoceptors in the mammalian heart. J. Mol. Cell. Cardiol. 17:1985;639-645.
10. 1-adrenoceptors relative to β-adrenoceptors in rat myocardium. Eur. J. Pharmacol. 218:1995;21-27.
11. Ebner F., Waud D.R. The role of uptake of noradrenaline for its positive inotropic effect in relation to muscle geometry. Arch. Pharmacol. 303:1978;1-6.
12. 1-adrenoceptors. Cardiovasc. Res. 27:1993;1735-1742.
13. 3H-(-)noradrenaline in the perfused cat and rabbit heart. Arch. Pharmacol. 318:1981;71-82.
14. Hasenfuss G., Blanchard E.M., Holubarsch C., Mulieri L.A, Alpert R.N. Influence of α- and β-receptor stimulation on myocardial energetics in rabbit myocardium. Circulation. II:1989;153. Suppl.
15. Iversen L.L. Some aspects of the pharmacology of drugs which interfere with noradrenaline uptake and storage. The Uptake and Storage of Noradrenaline. 1967;151-198 Cambridge Univ. Press, London.
16. Iversen L.L. Catecholamine uptake and processes. Br. Med. Bull. 29:1973;130-135.
17. Kalsner S. Mechanism of hydrocortisone potentiation of responses to epinephrine and norepinephrine in rabbit aorta. Circ. Res. 24:1969;383-395.
18. Kenakin T.P. Errors in the measurement of the agonist potency-ratios produced by uptake processes: a general model applied to β-adrenoceptor agonists. Br. J. Pharmacol. 71:1980;407-417.
19. Osnes J.-B., Aass H., Skomedal T. On adrenergic regulation of the heart function; role of myocardial α-adrenoceptors. Refsum H., Mjøs O.D. α-Adrenoceptor Blockers in Cardivascular Disease. 1985;69-102 Churchill and Livingstone, Edinburgh, London.
20. Scholz H. Effects of beta- and alpha-adrenoceptor activators and adrenergic transmitter releasing agents on the mechanical activity of the heart. Szekeres L. Handbook of Experimental Pharmacology: Vol. 54/I. Adrenergic Activators and Inhibitors, Part I. 1980;651-733 Springer-Verlag, Berlin, Heidelberg.
21. Skomedal T., Osnes J.-B. Qualitative differences between the inotropic responses in rat papillary muscles to α-adrenoceptor and β-adrenoceptor stimulation by both noradrenaline and adrenaline. Acta Pharmacol. Toxicol. 52:1983;57-67.
22. Skomedal T., Osnes J.-B., Øye I. Competitive blockade of α-adrenergic receptors in rat heart by prazosin. Acta Pharmacol. Toxicol. 47:1980;217-222.
23. Skomedal T., Aass H., Osnes J.-B., Fjeld N., Klingen G., Langslet A., Semb G. Demonstration of an alpha adrenoceptor-mediated inotropic effect of norepinephrine in human atria. J. Pharmacol. Exp. Ther. 233:1985;441-446.
24. Skomedal T., Schiander I., Osnes J.-B. Both alpha and beta adrenoceptor-mediated components contribute to the final inotropic response to norepinephrine in rat heart. J. Pharmacol. Exp. Ther. 247:1988;1204-1210.
25. Skomedal T., Aass H., Osnes J.-B. Prazosin-sensitive component of the inotropic response to norepinephrine in rabbit heart. J. Pharmacol. Exp. Ther. 252:1990;853-858.
26. Skomedal T., Borthne K., Aass H., Geiran O., Osnes J.-B. Comparison between alpha-1 adrenoceptor-mediated and beta adrenoceptor-mediated inotropic components elicited by norepinephrine in failing ventricular muscle. J. Pharmacol. Exp. Ther. 280:1997;721-729.
27. 1- and β-adrenoceptors in relation to sympathetic nerve endings in failing human myocardium. Arch. Pharmacol. 358(2):1998;R633. Suppl.
28. 2-adrenoceptor as a common 'adrenaline'-receptor in the vertebrate hearts. Comp. Biochem. Physiol. 70c:1981;1-12.
29. Terzic A., Pucèat M., Vassort G., Vogel S.M. Cardiac α-adrenoceptors: an overview. Pharmacol. Rev. 45:1993;147-195.
30. Trendelenburg U. Supersensitivity by cocaine to dextro rotatory isomers of norepinephrine and epinephrine. J. Pharmacol. Exp. Ther. 148:1965;329-338.
31. Verity M.A. Morphologic studies of the vascular neuroeffector apparatus. Proc. Symp. Physiol. Pharmacol. Vasc. Neuroeffector Systems. 1971;2-12 Karger, Basel.