Thermolabile H-2Kb molecules expressed by transporter associated with antigen processing-deficient RMA-S cells are occupied by low-affinity peptides

Journal of Immunology

Volumn 163, Issue 8, 1999, Pages 4413-4420

  De Silva, A Dharshan ^a   Boesteanu, Alina ^a   Song, Rui ^b   Nagy, Nancy ^b   Harhaj, Edward ^a   Harding, Clifford V ^b   Joyce, Sebastian ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; ABC TRANSPORTER; H 2KB PROTEIN, MOUSE; H-2KB PROTEIN, MOUSE; H2 ANTIGEN; TAP1 PROTEIN, HUMAN; TAP1 PROTEIN, MOUSE;

ANTIGEN BINDING; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; BINDING AFFINITY; CELL SURFACE; MOLECULAR INTERACTION; MOLECULAR STABILITY; PRIORITY JOURNAL; TEMPERATURE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CHEMISTRY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY TEST; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DENATURATION;

ANIMALS; ANTIGEN PRESENTATION; ATP-BINDING CASSETTE TRANSPORTERS; CYTOTOXICITY TESTS, IMMUNOLOGIC; H-2 ANTIGENS; MICE; MICE, INBRED C57BL; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DENATURATION; T-LYMPHOCYTES, CYTOTOXIC; TEMPERATURE; TUMOR CELLS, CULTURED;

EID: 0032589379     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Joyce, S., and S. G. Nathenson. 1996. Alloreactivity, antigen recognition and T cell selection: three diverse T cell recognition problems with a common solution. Immunol. Rev. 154:59.
2. Townsend, A. R. M., and H. Bodmer. 1989. Antigen recognition by class I restricted T lymphocytes. Annu. Rev. Immunol. 7:601.
3. Heemels, M.-T., and H. L. Ploegh. 1995. Generation, translocation and presentation of MHC class I restricted peptides. Annu. Rev. Biochem. 64:463.
4. Degan, E., and D. Williams. 1991. Participation of a novel 88 kD protein in the biogenesis of the murine class I histocompatibilily molecules. J. Cell Biol. 112: 1099.
5. Hsu, V. W., L. C. Yuan, J. G. Nuchtern, J. Lippincott-Schwartz, G. J. Hammerling, and R. D. Klausner. 1991. A recycling pathway between the endoplasmic reticulum and the Golgi apparatus for the retention of unassembled MHC class I molecules. Nature 352:441.
6. Jackson, M. R., M. F. Cohen-Doyle, P. A. Peterson, and D. Williams. 1994. Regulation of MHC class I transport by the molecular chaperone, calnexin (p88, IP90). Science 263:384.
7. Rajagopalan, S., and M. B. Brenner. 1994. Calnexin retains unassembled major histocompatibility complex class I free heavy chains in the endoplasmic reticulum. J. Exp. Med. 180:407.
8. Townsend, A. R. M., C. Ohlen, J. Bastin, H. G. Ljunggren, L. Foster, and K. Karre. 1989. Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature 340:443.
9. Townsend, A. R. M., T. Elliott, V. Cerundolo, L. Foster, B. barber, and A. Tse. 1990. Assembly of MHC class I molecules analyzed in vitro. Cell 62:285.
10. Schumacher, T. N., D. B.M., L. N. Vernie, W. M. Kast, C. J. M. Melief, and H. L. Ploegh. 1990. Direct binding of peptide to empty MHC class I molecules. Cell 62:563.
11. Ljunggren, H. G., H.-G. Stam, N. J. Ohlen, J. J. Neefjes, P. Hoglund, M.-T. Heemels, J. Bastin, T. N. M. Schumacher, A. R. M. Townsend, K. Karre, and H. L. Ploegh. 1990. Empty MHC class I molecules come out in the cold. Nature 446:476.
12. Baas, E. J., H.-M. van Santen, M. J. Kleijmeer, H. J. Geuze, P. J. Peters, and H. L. Ploegh. 1992. Peptide induced stabilization and intracellular localization of empty HLA class I complexes. J. Exp. Med. 176:147.
13. Cerundolo, V., J. Alexander, C. Lamb, P. Cresswell, A. J. McMicheal, F. M. Gotch, and A. R. M. Townsend. 1990. Presentation of viral antigen controlled by a gene in the MHC. Nature 345:449.
14. Ortiz-Navarrete, V., and G. J. Hammerling. 1991. Surface appearance and stability of empty H-2 class I molecules under physiological conditions. Proc. Natl. Acad. Sci. USA 88:3594.
15. Joyce, S., T. P. J. Garrett, J. Geliebter, R. Sun, and S. G. Nathenson. 1991. Structural correlates of MHC class I-restricted, antigen-specific, and alloreactive immunity. In Antigen Processing and Recognition, Ch. 5. J. McCluskey, ed. CRC Press, Boca Raton, p. 109.
16. Esquivel, F., J. W. Yewdell, and J. R. Bennink. 1992. RMA/S cells present endogenously synthesized cytosolic proteins to class I restricted cytotoxic T lymphocytes. J. Exp. Med. 175:163.
17. Hosken, N. A., and M. J. Bevan. 1992. An endogenous antigenic peptide bypasses the class I antigen presentation defect in RMA-S. J. Exp. Med. 175:719.
18. 2-microglobulin in the processing of bacterial or particulate antigens via an alternate class I MHC processing pathway. J. Immunol. 156:4182.
19. Karre, K., H.-G. Ljunggren, G. Piontek, and R. Kiessling. 1986. Selective rejection of H-2 deficient lymphoma variants suggests alternate immune defence strategy. Nature 319:675.
20. Yang, Y., K. Fruh, J. Chambers, J. B. Waters, L. Wu, T. Spies, and P. A. Peterson. 1992. Major histocompatibility complex (MHC) encoded HAM2 is necessary for antigenic peptide loading onto class I MHC molecules. J. Biol. Chem. 276:11669.
21. b) associated with unusually long peptides: implications for antigen processing and presentation. Proc. Natl. Acad. Sci. USA 91:4145.
22. Ajitkumar, P., S. S. Geier, K. V. Kesari, F. Borriello, M. Nakagawa, J. A. Bluestone, M. A. Saper, D. C. Wiley, and S. G. Nathenson. 1988. Evidence that multiple residues on both the α-helices of the class I MHC molecule are simultaneously recognized by the T cell receptor. Cell 54:47.
23. Van Bleek, G. M., and S. G. Nathenson. 1991. The structure of the antigen binding groove of major histocompatibility complex class I molecules determines specific selection of peptides. Proc. Natl. Acad Sci. USA 88:11032.
24. Pfeifer, J. D., M. J. Wick, R. L. Roberts, K. F. Findley, S. J. Normark, and C. V. Harding. 1993. Phagocytic processing of bacterial antigens for class I presentation to T cells. Nature 361:359.
25. Harding, C. V. 1994. Techniques for studying phagocytic processing of bacteria for class I and II MHC-restricted antigen recognition by T lymphocytes. Methods Cell Biol. 45:307.
26. 3H]-thymidine incorporation assay. J. Immunol. Methods 170: 211.
27. b molecule. Nature 348:213.
28. Falk, K., O. Rotzschke, S. Stevanovic, G. Jung, and H.-G. Rammensee. 1991. Allele-specific motifs revealed by sequencing of self peptides eluted from MHC molecules. Nature 351:290.
29. Rammensee, H. G., J. Bachmann, and S. Stevanovic. 1998. MHC Ligands and Peptide Motifs. R.G. Landes Bioscience, Austin.
30. Jardetzky, T. S., W. S. Lane, R. A. Robinson, D. R. Madden, and D. C. Wiley. 1991. Identification of self peptides bound to purified HLA-B27. Nature 353:326.
31. Joyce, S., P. Tabaczewski, R. H. Angeletti, S. G. Nathenson, and I. Stroynowski. 1994. A non-polymorphic MHC class Ib molecule binds a large array of diverse self peptides. J. Exp. Med. 179:577.
32. Joyce, S., A. S. Woods, J. W. Yewdell, J. R. Bennink, A. D. De Silva, A. Boesteanu, S. P. Balk, R. J. Cotter, and R. R. Brutkiewciz. 1998. Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol. Science 279:1541.
33. Day, P. M., F. Esquivel, J. Lukszo, J. R. Bennink, and J. W. Yewdell. 1995. Effect of TAP on the generation and intracellular trafficking of peptide receptive major histocompatibility complex class I molecules. Immunity 2:137.
34. Machold, R. P., S. Andree, L. Van Kaer, H.-G. Ljunggren, and H. L. Ploegh. 1995. Peptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains. J. Exp. Med. 181:1111.
35. Fujiwara, T., K. Oda, S. Yokota, A. Takatsuki, and Y. Ikehara. 1988. Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum. J. Biol. Chem. 263:18545.
36. Doms, R. W., G. Russ, and J. W. Yewdell. 1989. Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulum. J. Cell Biol. 109:61.
37. Lippincott-Schwartz, J., J. Donaldson, A. Schweizer, E. G. Berger, H.-P. Hauri, L. C. Yuan, and R. D. Klausner. 1990. Microtubule dependent retrograde transport of proteins into the ER in the presence of brefeldin A suggests an ER recycling pathway. Cell 60:821.
38. Lippincott-Schwartz, J., L. C. Yuan, C. Tipper, M. Amherdt, L. Orci, and R. D. Klausner. 1991. Brefeldin A's effects on endosomes, lysosomes and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic. Cell 67:601.
39. Suh, W., M. Cohen-Doyle, K. Fruh, K. Wang, P. P.A., and D. Williams. 1994. Interaction of MHC class I molecules with the transporter associated with antigen processing. Science 264:1322.
40. 2-microglobulin regulation of cell surface MHC class I conformation and expression. J. Immunol. 148:3723.
41. Wei, M. L., and P. Cresswell. 1992. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence derived peptides. Nature 356:443.
42. Anderson, K. S., J. Alexander, M. Wei, and P. Cresswell. 1993. Intracellular transport of class I MHC molecules in antigen processing mutant cell lines. J. Immunol. 151:3407.
43. Mendoza, L. M., P. Paz, A. Zuberi, G. Christianson, D. Roopenian, and N. Shastri. 1997. Minors held by majors: the H13 minor histocompatibility locus defined as a peptide/MHC class I complex. Immunity 7:461.
44. Rotzschke, O., K. Falk, S. Faath, and H.-G. Rammensee. 1991. On the nature of peptides involved in T-cell alloreactivity. J. Exp. Med. 174:1059.
45. Schirmbeck, R., and J. Reimann. 1994. Peptide transporter-independent, stress protein-mediated endosomal processing of endogenous protein antigens for major histocompatibility complex class I presentation. Eur. J. Immunol 24:1478.
46. Ulmer, J. B., J. J. Donnelly, and M. J. Liu. 1994. Presentation of an exogenous antigen by major histocompatibility complex class I molecules. Eur J. Immunol. 24:1590.
47. Bachman, M. F., A. Oxenius, H. Pircher, H. Hengartner, P. A. Ashton-Richardt, S. Tonegawa, and R. M. Zinkernagel. 1995. TAP1-independent loading of class I molecules by exogenous viral proteins. Eur. J. Immunol. 25:1739.
48. Schirmbeck, R., K. Melber, and J. Reimann. 1995. Hepatitis B virus small surface antigen particles are processed in a novel endosomal pathway for major histocompatibility complex class I-restricted epitope presentation. Eur. J. Immunol 25:1063.
49. Liu, T., X. Zhou, C. Orvell, E. Lederer, H.-G. Ljunggren, and M. Jondal. 1995. Heat-inactivated Sendai virus can enter multiple MHC class I processing pathways and generate cytotoxic T lymphocytes in vivo. J. Immunol. 154:3147.
50. Day, P. A., J. W. Yewdell, A. Porgador, R. N. Germain, and J. R. Bennink. 1997. Direct delivery of exogenous MHC class I molecule-binding oligopeptides to the endoplasmic reticulum of viable cells. Proc. Natl. Acad. Sci. USA 94:8064.