Selective β1-adrenoceptor blockade enhances the activity of the stimulatory G-protein in human atrial myocardium

British Journal of Pharmacology

Volumn 128, Issue 1, 1999, Pages 135-141

  Wang, Tao ^a   Plumpton, Christopher ^b   Brown, Morris J ^b  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b NONE

Author keywords

G protein; Human; Receptor cross regulation; S49 cyc reconstitution; Two dimensional gel electrophoresis; 1 adrenoceptor blockade

Indexed keywords

ATENOLOL; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); ADENYLATE CYCLASE; BETA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; ISOPROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ADULT; AGED; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CELL MEMBRANE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HEART ATRIUM; HEART MUSCLE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOBLOTTING; ISOELECTRIC POINT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; TWO DIMENSIONAL GEL ELECTROPHORESIS; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; MIDDLE AGED; MOLECULAR WEIGHT; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ADRENERGIC BETA-ANTAGONISTS; AGED; ATENOLOL; CELL MEMBRANE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HEART ATRIA; HUMANS; ISOELECTRIC POINT; MALE; MIDDLE AGED; MOLECULAR WEIGHT; MYOCARDIUM; PHOSPHORYLATION; PROTEIN ISOFORMS; RECEPTOR CROSS-TALK; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; TUMOR CELLS, CULTURED;

EID: 0032589311     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702750     Document Type: Article

References (33)

1. 1-and β2adrenoreceptors in human heart: properties, function, and alterations in chronic heart failure. Pharmacol. Rev., 43, 203-242.
2. s protein α subunit after activation by the β-adrenergic receptor or cholera toxin. J. Biol. Chem., 268, 23769-23772.
3. 2-Adrenoreceptors in single myocytes from human ventricle. Circulation, 88, 854-863.
4. Ferro, A., Plumpton, C. & Brown, M.J. (1993). Is receptor cross-regulation in human heart caused by alterations in cardiac guanine nucleotide-binding proteins? Clin. Sci., 85, 393-399.
5. Gao, B. & Gilman, A.G. (1991). Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Proc. Natl. Acad. Sci. U.S.A., 88, 10178-10182.
6. Haga, T., Ross, E.M., Anderson, H.J. & Gilman, A.G. (1977). Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells. Proc. Natl. Acad. Sci. U.S.A., 74, 2016-2020.
7. Hall, J.A., Ferro, A., Dickerson, J.E. & Brown, M.J. (1993). Beta adrenoceptor subtype cross regulation in the human heart. Br. Heart J., 69, 332-337.
8. 2-adrenoreceptors in human atrial myocardium. Circ. Res., 66, 1610-1623.
9. 2-adrenoreceptor sensitisation by β1-antagonist treatment. Circ. Res., 9, 959-964.
10. Iaccarino, G., Tomhave, E.D., Lefkowitz, R.J. & Koch, W.J. (1998). Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by β-adrenergic receptor stimulation and blockade. Circulation, 98, 1783-1789.
11. Ishikawa, Y. & Homcy, C.J. (1997). The adenylyl cyclase as integrators of transmembrane signal transduction. Circ. Res., 80, 297-304.
12. Ishikawa, Y., Katsushika, S., Chen, L., Halnon, N.J., Kawabe, J. & Homcy, C. (1992). Isolation and characterisation of a novel cardiac adenylylcyclase cDNA. J. Biol. Chem., 267, 13553-13557.
13. s-stimulated adenylyl cyclases. FASEB J., 7, 768-775.
14. 1-adrenoreceptor-blocked and non-β-adrenoreceptor-blocked human atrium. Clin. Sci., 88, 571-580.
15. Katsushika, S., Chen, L., Kawabe, J., Nilakantan, R., Halnon, N.J., Homcy, C.J. & Ishikawa, Y. (1992). Cloning and characterisation of a sixth adenylyl cyclase isoform: Type V and VI constitute a subgroup within the mammalian adenylyl cyclase family. Proc. Natl. Acad. Sci. U.S.A., 89, 8774-8778.
16. 2-Adrenoreceptor-mediated positive inotropic effect of adrenaline in human ventricular myocardium. Quantitative discrepancies with binding and adenylate cyclase stimulation. Naunyn-Schmiedeberg's Arch. Pharmacol., 335, 403-411.
17. Krupinski, J., Coussen, F., Bakalyar, H.A., Tang, W.J., Feinstein, P.G., Orth, K., Slaughter, C., Reed, R.R. & Gilman, A.G. (1989). Adenylyl cyclase amino acid sequence: possible channel-or transporter-like structure. Science, 244, 1558-1564.
18. Linder, M.E., Middleton, P., Hepler, J.R., Taussig, R., Gilman, A.C. & Mumby, S.M. (1993). Lipid modification of G Proteins: α subunits are palmitoylated. Proc. Natl. Acad. Sci. U.S.A., 90, 3675-3679.
19. s promotes its removal from the plasma membrane. Biochem. J., 260, 837-841.
20. sα, the stimulatory G-protein, in human atrium. Clin. Sci., 89, 487-495.
21. O'Farrel, P.H. (1975). High resolution two-dimensional elcctrophoresis of proteins. J. Biol. Chem., 250, 4007-4021.
22. Ohisalo, J.J., Vikman, H.L., Ranta, S., Houslay, M.D. & Milligan, G. (1989). Adipocyte plasma-membrane Gi and Gs in insulinopenic diabetic patients. Biochem. J., 262, 289-292.
23. Ping, P., Gelzer-Bell, R., Roth, D.A., Kiel, D., Insel, P.A. & Hammond, H.K. (1995). Reduced β-adrenergic receptor activation decrease G-protein expression and β-adrenergic receptor kinase activity in porcine heart. J. Clin. Invest., 95, 1271-1280.
24. Premont, R.T., Chen, J., Ma., H., Ponnapalli, M. & Iyengar, R. (1992). Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases. Proc. Natl. Acad. Sci. U.S.A., 89, 9809-9813.
25. s by the catalytic sub-unit of protein kinase A. Biochem. Biophys. Res. Commun., 186, 1081-1086.
26. s and intracellular cyclic AMP. Br. J. Pharmacol., 108, 74.
27. Ross, E.M. & Gilman, A.G. (1977). Reconstitution of catecholamine-sensitive adenylate cyclase activity: interaction of solubilized components with receptor-replete membranes. Proc. Natl. Acad. Sci. U.S.A., 74, 3715-3719.
28. 4 receptors by chronic β-blocker treatment. Circulation, 92, 2526-2539.
29. 2 receptor systems in human atrium: role of cyclic nucleotides. Naunyn-Schmiedeberg's Arch. Pharmacol., 353, 611-670.
30. sα isoforms in human atrium and blood vessels. Clin. Sci., 35, 2.
31. Watson, P.A., Krupinski, J., Kempinski, A.M. & Frankenfield, C.D. (1994). Molecular cloning and characterisation of the Type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells. J. Biol. Chem., 269, 28893-28898.
32. Yamane, H.K. & Fung, B.K.K. (1993). Covalent modification of G-proteins. Annu. Rev. Pharmacol. Toxicol., 32, 201-241.
33. Zhou, Y.Y., Cheng, H., Bogdanov, K.Y., Hohl, C., Altschuld, R., Lakatta, E.G. & Xiao, R.P. (1997). Localized cAMP-dependent signaling mediates beta 2-adrenergic modulation of cardiac excitation-contraction coupling. Am. J. Physiol., 273, H1611-H1618.