Fcγ receptor-mediated inhibition of human B cell activation: The role of SHP-2 phosphatase

European Journal of Immunology

Volumn 29, Issue 6, 1999, Pages 1980-1989

  Koncz, Gábor ^a   Pecht, Israel ^b   Gergely, János ^a   Sármay, Gabriella ^a  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

B cell; Fc RIIb; Human; SHP 2

Indexed keywords

FC RECEPTOR; LYMPHOCYTE RECEPTOR; PROTEIN TYROSINE PHOSPHATASE; PEPTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; PTPN6 PROTEIN, HUMAN; PTPN6 PROTEIN, MOUSE; SIGNAL PEPTIDE; SRC HOMOLOGY 2 (SH2) DOMAIN CONTAINING PHOSPHATASES; SRC HOMOLOGY-2 (SH2) DOMAIN-CONTAINING PHOSPHATASES; TYROSINE;

ARTICLE; B LYMPHOCYTE ACTIVATION; DEPHOSPHORYLATION; HUMAN; HUMAN CELL; LYMPHOMA CELL LINE; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANIMAL; B LYMPHOCYTE; BINDING SITE; CELL LINE; ENZYMOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; MOUSE; PHOSPHORYLATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; ANIMALS; B-LYMPHOCYTES; BINDING SITES; CELL LINE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PEPTIDES; PHOSPHORYLATION; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTORS, IGG; SHP1 PROTEIN TYROSINE PHOSPHATASE; SRC-FAMILY KINASES; TYROSINE;

EID: 0032589057     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199906)29:06<1980::AID-IMMU1980>3.0.CO;2-B     Document Type: Article

References (30)

1. Chan, P. L. and Sinclair, N. R. S. C., Regulation of the immune response. V. An analysis of the function of the Fc portion of antibody in suppression of an immune response with respect to interaction with components of the lymphoid system. Immunology 1971. 21: 967-972.
2. Daeron, M., Fc receptor biology. Annu. Rev. Immunol. 1997. 15: 203-234.
3. Bijsterbosch, M. K. and Klaus, G. G. B., Crosslinking of surface immunoglobulin abd Fc receptors on B lymphocytes inhibits stimulation of inositol phospholipid breakdown via the antigen receptors. J. Exp. Med. 1985. 162: 1825-1836.
4. Muta, T., Kurosaki, T., Misulovin, Z., Sanchez, M., Nussenzweig, M. C. and Ravetch, J. V., A 13 amino-acid motif in the cytoplasmic domain of FcγRIIb modulates B cell receptor signalling. Nature 1994. 368: 70-73.
5. Amigorena, S., Bonnerot, C., Drake, J., Choquet, D., Hunziker, W., Guillet, J. G., Webster, P., Sautes, C., Mellman, I. and Fridman, W. H., Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes. Science 1992. 256: 1808-1812.
6. Scharenberg, A. M. and Kinet, J. P., The emerging field of receptor mediated inhibitory signaling: SHP or SHIP. Cell 1996. 87: 961-964.
7. D'Ambrosio, D., Hippen, K. H., Minskoff, S. A., Mellman, I., Pani, G., Siminovitch, K. A. and Cambier, J. C., Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling. Science 1995. 268: 293-296.
8. D'Ambrosio, D., Fong, D. C. and Cambier, J. C., The SHIP phosphatase becomes associated with Fc gammaRIIb1 and is tyrosine phosphorylated during negative signaling. Immunol. Lett. 1996. 54: 77-82.
9. Ono, M., Bolland, S., Tempst, P. and Ravetch, J. V., Role of inositol phosphatase SHIP in negative regulation of the immune system by FcγRIIb. Nature 1996. 383: 263-266.
10. Nadler, M. J. S., Chen, B., Anderson, J. S., Wortis, H. H. and Neel, B. G., Protein tyrosine phosphatase SHP-1 is dispensable for FcgammaRIIb-mediated inhibition of B cell antigen receptor activation. J. Biol. Chem. 1997. 272: 20083-20088.
11. Ono, M., Okada, H., Bolland, S., Yanagi, S., Kurosaki, T. and Ravetch, J. V., Deletion of SHIP or SHP-1 reveals two distinct pathways of inhibitory signaling. Cell 1997. 90: 293-301.
12. Fong, D. C., Malbec, O., Arock, M., Cambier, J. C., Fridman, W. H. and Daeron, M., Selective in vivo recruitment of the phosphatidyl inositol phosphatase SHIP by phosphorylated Fcgamma RIIb during negative regulation of IgE dependent mouse mast cell activation. Immunol. Lett. 1996. 54: 83-87.
13. Sármay, G., Recht, I. and Gergely, J., Protein tyrosine kinase activity tightly associated with human type II Fcgamma receptors. Proc. Natl. Acad. Sci. USA 1994. 91: 4140-4144.
14. Sármay, G., Koncz, G. and Gergely, J., Human type II Fc gamma receptors inhibit B cell activation by interacting with the p21 ras-dependent pathway. J. Biol. Chem. 1996. 271: 30499-30504.
15. Sármay, G., Koncz, G. and Gergely, J., Integration of activatory and inhibitory signals in human B cells. Immunol. Lett. 1996. 54: 93-100.
16. Sármay, G., Koncz, G., Pecht, I. and Gergely, J., Fcγreceptor IIb induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell. Immunol. Lett. 1997. 57: 159-164.
17. Crowley, M. T., Harmer, S. L. and DeFranco, A. L., Activation induced association of a 145 kDa tyrosine phosphorylated protein with Shc and Syk in B lymphocytes and macrophages. J. Biol. Chem. 1996. 271: 1145-1152.
18. Takai, T., Ono, M., Hikida, M., Ohmori, H. and Ravetch, J. V., Augmented humoral anaphylactic responses in Fcgamma RII-deficient mice. Nature 1996. 379: 346-349.
19. Phillips, N. E. and Parker, D. C., Fc-dependent inhibition of mouse B cell activation by whole anti-IgM antibodies. J. Immunol. 1983. 130: 602-606.
20. Bolland, S., Pearse, R. N., Kurosaki, T. and Ravetch, J. V., SHIP modulates immune receptor responses by regulating membrane association of Btk. Immunity 1998. 8: 509-516.
21. Wang, J., Koizumi, T. and Watanabe, T., Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B-cells in Lyn-deficient mice. J. Exp. Med. 1996. 184: 831-838.
22. Liu, L., Damen, J. E., Hughes, M. R., Babic, I., Jirik, S. R. and Krystal, G., The Src homology 2 (SH2) domain of SH2-domain containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP its association with Shc and its induction of apoptosis. J. Biol. Chem. 1997. 272: 8983-8988.
23. Liu, L., Damen, J. E., Ware, M. D. and Krystal, G., Interleukin-3 induces the association of inositol 5-phosphatase SHIP with SHP-2. J. Biol. Chem. 1997. 272: 10998-11001.
24. Sattler, M., Salgia, R., Shrikhande, G., Verma, S., Choi, J. L., Rohrschneider, L. R. and Griffin, J. D., The phosphatidyl inositol 5-phosphatase SHIP and the protein phosphatase SHP-2 form a complex in hematopietic cells which can be regulated by BCR/ABL and growth factors. Oncogene 1997. 15: 2379-2384.
25. Delibrias, C. C., Floetmann, J. E., Rowe, M. and Fearon, D. T., Downregulated expression of SHP-1 in Burkitt lymphomas and germinal center B lymphocytes. J. Exp. Med. 1997. 186: 1575-1583.
26. Hof, P., Pluskey, S., Dhe-Paganon, S., Eck, M. J. and Shoelson, S. E., Crystal structure of the tyrosine phosphatase SHP-2. Cell 1998. 92: 441-450.
27. Marengere, L. E., Waterhouse, P., Duncan, G. S., Mittrucker, H. W., Feng, G. S. and Mak, T. W., Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 1996. 272: 1170-1173.
28. Sármay, G., Koncz, G., Pecht, I. and Gergely, J., Cooperation between SHP-2, phosphatidyl 3-kinase and inositol 5-phosphatase in the FcγRIIb mediated B cell regulation. Immunol. Lett. 1999. 68: 25-34.
29. + mobilization is integrated by CD19 dephosphorylation. Immunity 1997. 7: 49-58.
30. Kiener, P. A., Lioubin, M. N., Rohrschneider, L. R., Ledbetter, J. A., Nadler, S. G. and Diegel, M. L., Coligation of the antigen and Fc receptors gives rise to the selective modulation of intracellular signaling in B cells Regulation of the association of phosphatidyl inositol 3-kinase and inositol 5-phosphatase with the antigen receptor complex. J. Biol. Chem. 1997. 272: 3838-3844.