[3H]gemcitabine uptake by nucleoside transporters in a human head and neck squamous carcinoma cell line

Journal of Pharmacology and Experimental Therapeutics

Volumn 288, Issue 3, 1999, Pages 1185-1191

  Hammond, James R ^a   Lee, Stephanie ^a   Ferguson, Peter J ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; DIPYRIDAMOLE; FORMYCIN B; GEMCITABINE; NITROBENZYLTHIOINOSINE; NUCLEOSIDE ANALOG; TRITIUM; URIDINE; ANTINEOPLASTIC ANTIMETABOLITE; DEOXYCYTIDINE; DRUG DERIVATIVE; FORMYCIN DERIVATIVE; MEMBRANE PROTEIN; NUCLEOSIDE TRANSPORTER;

ARTICLE; CANCER CELL CULTURE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG EFFICACY; DRUG TRANSPORT; DRUG UPTAKE; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; NUCLEOSIDE TRANSPORT; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; CELL CULTURE; COMPARATIVE STUDY; DRUG RESISTANCE; HEAD AND NECK TUMOR; METABOLISM; TIME;

ADENOSINE TRIPHOSPHATE; ANTIMETABOLITES, ANTINEOPLASTIC; CARCINOMA, SQUAMOUS CELL; CARRIER PROTEINS; DEOXYCYTIDINE; DRUG RESISTANCE; FORMYCINS; HEAD AND NECK NEOPLASMS; HUMANS; MEMBRANE PROTEINS; NUCLEOSIDE TRANSPORT PROTEINS; TIME FACTORS; TRITIUM; TUMOR CELLS, CULTURED; URIDINE;

EID: 0032588712     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Baer HP, Moorji A, Ogbunude POJ and Serignese V (1992) Sodium-dependent nucleoside transport in mouse lymphocytes, human monocytes, and hamster macrophages and peritoneal exudate cells. Can J Physiol Pharmacol 70:29-35.
2. Belt JA, Marina NM, Phelps DA and Crawford CR (1993) Nucleoside transport in normal and neoplastic cells. Adv Enzyme Regal 33:235-252.
3. Braakhuis BJ, van Dongen GA, Vermerken JB and Snow GB (1991) Preclinical in vivo activity of 2′ ,2′-difluorodeoxycytidine (Gemcitabine) against human head and neck cancer. Cancer Res 51:211-214.
4. +-dependent and -independent nucleoside transporters of Ehrlich ascites tumor cells. J Pharmacol Exp Ther 286:1333-1340.
5. Cass CE (1995a) Nucleoside transport, in Drug Transport in Antimicrobial Therapy and Anticancer Therapy (Georgopapadakou NH ed) pp 403-452, Marcel Dekker, New York.
6. Cass CE (1995b) Membrane transport of anticancer drugs and drug resistance, in Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s (Cuello AC and Collier B eds) pp 413-431, Birkhauser Verlag, Basel, Switzerland.
7. Dagnino L, Bennett LL Jr and Paterson ARP (1991) Sodium-dependent nucleoside transport in mouse leukemia L1210 cells. J Biol Chem 266:6308-6311.
8. +-dependent and -independent uridine uptake in an established renal epithelial cell line, OK, from the opossum kidney. Biochim Biophys Acta Bio-Membr 1147:214-222.
9. rat) by transient expression in cultured mammalian cells. Biochem J 317:457-465.
10. Griffith DA and Jarvis SM (1996) Nucleoside and nucleobase transport systems of mammalian cells. Biochim Biophys Acta Rev Biomembr 1286:153-181
11. Griffiths M, Beaumont N, Yao SYM, Sundaram M, Boumah CE, Davies A, Kwong FYP, Coe I, Cass CE, Young JD and Baldwin SA (1997) Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs. Nat Med 3:89-93.
12. Guchelaar HJ, Richel DJ and van Knapen A (1996) Clinical, toxicological and pharmacological aspects of gemcitabine. Cancer Treat Rev 22:15-31.
13. Hammond JR (1991) Comparative pharmacology of the nitrobenzylthioguanosinesensitive and -resistant nucleoside transport mechanisms of Ehrlich ascites tumor cells. J Pharmacol Exp Ther 259:799-807.
14. Hammond JR and Johnstone RM (1989) Solubilization and reconstitution of a nucleoside-transport system from Ehrlich ascites-tumour cells. Biochem J 262: 109-118.
15. Hammond JR, Williams EF and Clanachan AS (1985) Affinity of calcium channel inhibitors, benzodiazepines, and other vasoactive compounds for the nucleoside transport system. Can J Physiol Pharmacol 63:1302-1307.
16. Heinemann V, Hertel LW, Grindey GB and Plunkett W (1988) Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluorodeoxycytidine and 1-β-D-arabinofuranosykytosine. Cancer Res 48:4024-4031.
17. Hui YF and Reitz J (1997) Gemcitabine: A cytidine analog active against solid tumors. Am J Health Syst Pharm 54:162-170.
18. Jansen WJM, Pinedo HM, van der Wilt CL, Feller N, Bamberger U and Boven E (19951 The influence of BIBW22BS, a dipyridamole derivative, on the antiproliferative effects of 5-fluorouracil, methotrexate and gemcitabine in vitro and in human tumour xenografts. Eur J Cancer [A] 31:2313-2319.
19. Jarvis SM (1989) Characterization of sodium-dependent nucleoside transport in rabbit intestinal brush-border membrane vesicles. Biochim Biophys Acta 979:132-138.
20. Lapointe H, Lampe H and Banerjee D (1992) Head and neck squamous cell carcinoma cell line-induced suppression of in vitro lymphocyte proliferative responses. Otolaryngol Head Neck Surg 106:149-158.
21. Lund B, Kristjansen PEG and Hansen H (1993) Clinical and preclinical activity of 2′,2′-difluorodeoxycytidine (gemcitabine). Cancer Treat Rev 19:45-55.
22. Mackey JR, Mowles D, Selner M, Cass CE and Young J (1998) Gemcitabine plasma membrane uptake kinetics of three human nucleoside transporters. Proc Am Assoc Cancer Res 39:216-216.
23. Noble S and Goa KL (1997) Gemcitabine: A review of its pharmacology and clinical potential in non-small cell lung cancer and pancreatic cancer. Drags 54:447-472.
24. +-dependent, active nucleoside transport in rat and mouse peritoneal macrophages, a mouse macrophage cell line and normal rat kidney cells. Biochim Biophys Acta Bio-Membr 1028:289-298.
25. Plagemann PGW and Woffendin C (1989) Use of formycin B as a general substrate for measuring facilitated nucleoside transport in mammalian cells. Biochim Biophys Acta 1010:7-15.
26. Plunkett W, Haung P, Xu YZ, Heinemann V, Grunewald R and Gandhi V (1995) Gemcitabine: Metabolism, mechanisms of action, and self-potentiation. Semin Oncol 22:3-10.
27. Ross DD and Cuddy DP (1994) Molecular effects of 2′,2′-difluorodeoxycytidine (Gemcitabine) on DNA replication in intact HL-60 cells. Biochem Pharmacol 48:1619-1630.
28. Ruiz van Haperen VWT, Veerman G, Eriksson S, Stegmann APA and Peters GJ (1995) Induction of resistance to 2′,2′-difluorodeoxycytidine in the human ovarian cancer cell line A2780. Senim Oncol 22:35-41.
29. Spector R and Huntoon S (1984) Specificity and sodium dependence of the active nucleoside transport system in choroid plexus. J Neurochem 42:1048-1052.
30. Stein WD (1997) Kinetics of the multidrug transporter (P-glycoprotein) and its reversal. Physiol Rev 77:545-590.
31. Waud WR, Gilbert KS, Grindey GB and Worzalla JF (1996) Lack of in vivo cross-resistance with gemcitabine against drug-resistant murine P388 leukemias. Cancer Chemother Pharmacol 38:178-180.
32. White JC, Rathmell JP and Capizzi RL (1987) Membrane transport influences the rate of accumulation of cytosine arabinoside in human leukemia cells. J Clin Invest 79:380-387.
33. Williams TC and Jarvis SM (1991) Multiple sodium-dependent nucleoside transport systems in bovine renal brush-border membrane vesicles. Biochem J 274:27-33.