Involvement of phospholipase A2 activation in anthrax lethal toxin- induced cytotoxicity

Cell Biology and Toxicology

Volumn 15, Issue 1, 1999, Pages 19-29

  Shin, Sungho ^a   Kim, Y B ^a   Hur, G H ^a  

^a Agency for Defence Development   (South Korea)

Author keywords

Anthrax lethal toxin; Cytotoxicity; Macrophage; Phospholipase A2; Protein kinase

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 4 BROMOPHENACYL BROMIDE; ANTHRAX TOXIN; BUTACAINE; DNA FRAGMENT; GENISTEIN; MANOALIDE; MELATONIN; MEPACRINE; NITRIC OXIDE; PHOSPHOLIPASE A2; PRASTERONE; PROTEIN KINASE; STAUROSPORINE; 4 AMINOBENZOIC ACID; 4-BROMOPHENACYL BROMIDE; ACETOPHENONE DERIVATIVE; ANTIOXIDANT; BACTERIAL ANTIGEN; BACTERIAL TOXIN; DRUG DERIVATIVE; ENZYME INHIBITOR; PHOSPHODIESTERASE INHIBITOR; PHOSPHOLIPASE A; PROTEIN KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; TERPENE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BACILLUS ANTHRACIS; CELL CULTURE; CELL MEMBRANE; CELL VIABILITY; CHEMICAL ANALYSIS; CONCENTRATION RESPONSE; CYTOTOXICITY; DISEASE COURSE; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEPTOR BINDING; ANIMAL; ANTHRAX; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PERITONEUM MACROPHAGE;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; 4-AMINOBENZOIC ACID; ACETOPHENONES; ANIMALS; ANTHRAX; ANTIGENS, BACTERIAL; ANTIOXIDANTS; APOPTOSIS; BACTERIAL TOXINS; CELLS, CULTURED; DEHYDROEPIANDROSTERONE; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME INHIBITORS; MACROPHAGES, PERITONEAL; MELATONIN; MICE; MICE, INBRED ICR; NITRIC OXIDE; PHOSPHODIESTERASE INHIBITORS; PHOSPHOLIPASES A; PROTEIN KINASE INHIBITORS; QUINACRINE; REACTIVE OXYGEN SPECIES; STAUROSPORINE; TERPENES;

EID: 0032587791     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007546505528     Document Type: Article

References (42)

1. Akiyama T, Ishida J, Nagagawa S. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem. 1987;262:5592-5.
2. Albina JE, Cui S, Mateo RB, Reichner S. Nitric oxide-mediated apoptosis in murine peritoneal macrophages. J Immunol. 1993;150:5080-5.
3. Araghiniknam M, Chung S, Nelson-White T, Eskelson C, Watson RR. Antioxidant activity of dioscorea and dehydroepiandrosterone in older humans. Life Sci. 1996;59:147-57.
4. 1 macrophages. J Biol Chem. 1996;271:6758-65.
5. 2 enzymes. Proc Natl Acad Sci USA. 1994;91:1106-4.
6. Bhatnagar R, Friedlander AM. Protein synthesis is required for expression of anthrax lethal toxin cytotoxicity. Infect Immun. 1994;62:2958-62.
7. Bhatnagar R, Singh Y, Leppla SH, Friedlander AM. Calcium is required for the expression of anthrax lethal toxin activity in the macrophage-like cell line J774A.1. Infect Immun. 1989; 57:2107-14.
8. Bonfoco E, Kraine D, Ankarcrona M, Nicotera P, Lipton S. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA. 1995;92:7162-6.
9. Choi DS, Shin S, Kim YB, Cha SH, Sok DE. An additional mechanism for the cytotoxicity of 2-chlororthylethyl sulfide in spleen lymphocytes. J Biochem Mol Biol. 1995;28:79-82.
10. Danenberg HD, Ben-Yehuda A, Zakay-Rones Z, Friedman G. Dehydroepiandrosterone treatment reverses the impaired immune response of old mice to influenza vaccination and protects from influenza infection. Vaccine. 1995;13:1445-8.
11. 2. J Biol Chem. 1994;269:13057-60.
12. Duan H, Chinnaiyan AM, Hudson PL, Wing JP, He W, Dixit VM. ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis. J Biol Chem. 1996;271:1621-5.
13. Fink DW, Guroff G. Nerve growth factor stimulation of arachidonic acid release from PC12 cells: independence from phosphoinositide turnover. J Neurochem. 1990;55: 1716-26.
14. Friedlander AM. Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process. J Biol Chem. 1986;261:7123-6.
15. 1 macrophage-like cells for enhanced arachidonic acid metabolism. J Biol Chem. 1990;265:8658-64.
16. 2 activation. Biochem J. 1990;267:461-5.
17. 15N]-nitrate in biological fluids. Anal Biochem. 1982;126:131-8.
18. Hale AJ, Smith CA, Sutherland LC. Apoptosis: molecular regulation of cell death. Eur J Biochem. 1996;236:1-26.
19. Hanna PC, Acosta D, Collier RJ. On the role of macrophages in anthrax. Proc Natl Acad Sci USA. 1993;90:10198-201.
20. Hanna PC, Kruskal BA, Ezekowitz AB, Bloom BR, Collier RJ. Role of macrophage oxidative burst in the action of anthrax lethal toxin. Mol Med. 1994;1:7-18.
21. 2. J Biol Chem. 1991;266: 7227-32.
22. Hofmann SL, Prescott SM, Majerus PW. The effects of mepacrine and p-bromophenacyl bromide on arachidonic acid release in human platelets. Arch Biochem Biophys. 1982;215:237-44.
23. Kawamoto S, Hidaka H. 1-(-5-Isoquinolinesulfonyl)-2-methyl-piperazine (H-7) is a selective inhibitor of protein kinase C in rabbit platelet. Biochem Biophys Res Commun. 1984; 125:258-64.
24. Klimpel KR, Arora M, Leppla SH. Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity. Mol Microbiol. 1994;13: 1093-100.
25. Kolb H, Kolb-Bachofen V. Nitric oxide: a pathogenetic factor in autoimmunity. Immunol Today. 1992;13:157-62.
26. Leppla SH. Bacillus anthracis calmodulin dependent adenyl cyclase: chemical and enzymatic properties and interaction with eucaryotic cells. Cyclic Nucleo Protein Phosphoryl Res. 1984;19:189-98.
27. Leppla SH. Production and purification of anthrax toxin. Methods Enzymol. 1988;165:103-16.
28. Leppla SH. The anthrax toxin complex. In: Alouf J, ed. Source-book of bacterial protein toxins. New York: Academic Press; 1991:277-302.
29. 4 hydrolase and metallopeptidase inhibitors. Biochem J. 1996;320:687-91.
30. Meyer T, Regenass U, Fabbro D. A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity. Int J Cancer. 1989;43:851-6.
31. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev. 1991; 43:109-42.
32. 2 enzymes: regulation and physiological role. Biochem Pharmacol. 1994;48:1-10.
33. Nathan CF. Nitric oxide as a secretory product of mammalian cells. FASEB J. 1992;6:3051-64.
34. Poeggeler B, Reiter RJ, Tan DX, Chen LD, Manchester LC. Melatonin, hydroxyl radical-mediated oxidative damage and aging: a hypothesis. J Pineal Res. 1993;14:151-68.
35. Pozo D, Reiter RJ, Calvo JP, Guerrero JM. Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum. Life Sci. 1994;55:PL455-60.
36. Ray P, Berman JD, Middleton W, Brendle J. Botulinum toxin inhibits arachidonic acid release associated with acetylcholine release from PC12 cells. J Biol Chem. 1993;268: 11057-64.
37. Reiter RJ, Melchiorri D, Sewerynek E. A review of the evidence supporting melatonin's role as an antioxidant. J Pineal Res. 1995;18:1-11.
38. Segal AW, Abo A. The biochemical basis of the NADPH oxidase of phagocytes. Trends Biochem Sci. 1993;18:43-7.
39. Stephen J. Anthrax toxin. In: Doner F, Drews J, eds. Pharmacology of bacterial protein toxins. Oxford: Pergamon Press; 1986:381-95.
40. 2. Biochemistry. 1993;32:5935-40.
41. Ueda N, Shah S. Apoptosis. J Lab Clin Med. 1994;124:169-77.
42. Wheeler LA, Sachs G, DeVries G, Goodrum D, Woldemussie E, Muallen S. Manoalide, a natural sesterterpenoid that inhibits calcium channels. J Biol Chem. 1987;262:6531-8.