Loss of D2 receptor binding with age in rhesus monkeys: Importance of correction for differences in striatal size

Journal of Cerebral Blood Flow and Metabolism

Volumn 19, Issue 2, 1999, Pages 218-229

  Morris, Evan D ^a   Chefer, Svetlana I ^a   Lane, Mark A ^b   Muzic Jr , Raymond F ^c   Wong, Dean F ^d   Dannals, Robert F ^d   Matochik, John A ^a   Bonab, Ali A ^e   Villemagne, Victor L ^d   Grant, Steven J ^a   Ingram, Donald K ^b   Roth, George S ^b   London, Edythe D ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Aging; Dopamine; Partial volume; Positron emission tomography; Raclopride

Indexed keywords

DOPAMINE; DOPAMINE 2 RECEPTOR; RACLOPRIDE; RADIOLIGAND;

AGING; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CORPUS STRIATUM; DOPAMINERGIC SYSTEM; DOSE TIME EFFECT RELATION; MALE; MATHEMATICAL ANALYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECEPTOR BINDING; RHESUS MONKEY; SIMULATION; ANIMAL; COMPUTER ASSISTED EMISSION TOMOGRAPHY; HISTOLOGY; MACACA; METABOLISM; PUTAMEN; SCINTISCANNING;

AGING; ANIMALS; CORPUS STRIATUM; MACACA MULATTA; MAGNETIC RESONANCE IMAGING; MALE; PUTAMEN; RECEPTORS, DOPAMINE D2; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0032587502     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199902000-00013     Document Type: Article

References (14)

1. 11C-raclopride. Arch Neurol 50:474-480
2. Bendriem B, Dewey SL, Schlyer DJ, Wolf AP, Volkow ND (1991) Quantitation of human basal ganglia with positron emission tomography: a phantom study of the effect of contrast and axial positioning. IEEE Trans Med Imaging 10:216-222
3. Bowden DM, Williams DD (1984) Aging. Adv Vet Sci Comp Med 28:305-341
4. 11C]raclopride binding with continuous infusion. J Cereb Blood Flow Metab 17:437-447
5. 2 receptor ligands. J Labelled Comp Radiopharm 24:931-940
6. 2-dopamine receptors studied by PET: a comparison to the equilibrium analysis. J Cereb Blood Flow Metab 9:696-708
7. Huffman EJ, Huang SC, Phelps ME (1979) Quantitation in positron emission computed tomography. I. Effect of object size. J Comput Assist Tomogr 3:299-308
8. 11C]raclopride binding in rat striatum, quantified using PET. Synapse 21:45-53
9. 2 receptor binding with iodine-123-IBF SPECT. J Nucl Med 38:146P
10. Ingram DK, Cutler RG, Weindruch R, Renquist DM, Knapka JJ, April M, Belcher CT, Clark MA, Hatcherson CD, Marriott BM (1990) Dietary restriction and aging: the initiation of a primate study. J Gerontol 45:B148-163
11. Kessler RM, Ellis JR Jr, Eden M (1984) Analysis of emission tomographic scan data: limitations imposed by resolution and background. J Comput Assist Tomogr 8:514-522
12. Lai H, Bowden DM, Horita A (1987) Age-related decreases in dopamine receptors in the caudate nucleus and putamen of the Rhesus monkey (Macaca mulatta). Neurobiol Aging 8:45-49
13. Lane MA, Ingram DK, Cutler RG, Knapka JJ, Barnard DE, Roth GS (1992) Dietary restriction in nonhuman primates: progress report on the NIA study. Ann NY Acad Sci 673:36-45
14. Links JM, Zubieta JK, Meltzer CC, Stumpf MJ, Frost JJ (1996) Influence of spatially heterogeneous background activity on "hot object" quantitation in brain emission computed tomography. J Comput Assist Tomogr 20:680-687