Immunolocalization of the four prostaglandin E2 receptor proteins EP1, EP2, EP3, and EP4 in human kidney

Journal of the American Society of Nephrology

Volumn 10, Issue 9, 1999, Pages 1851-1860

  Morath, Ruta ^a   Klein, Thomas ^a   Seyberth, Hannsjörg W ^a   Nüsing, Rolf M ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CALCIUM ION; CYCLIC AMP; MESSENGER RNA; POLYCLONAL ANTIBODY; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROTEIN KINASE C; RECEPTOR PROTEIN; RECEPTOR SUBTYPE; RENIN; PEPTIDE FRAGMENT; PROSTAGLANDIN E2 RECEPTOR, EP4 SUBTYPE; PROSTAGLANDIN EP2 RECEPTOR; PROSTAGLANDIN EP3 RECEPTOR; PROSTANOID RECEPTOR EP1;

ARTERIOLE; ARTERY ENDOTHELIUM; ARTERY MEDIA; ARTICLE; GLOMERULUS; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KIDNEY BLOOD VESSEL; KIDNEY DISTAL TUBULE; KIDNEY MEDULLA; KIDNEY PARENCHYMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RENIN RELEASE; SODIUM ABSORPTION; WATER ABSORPTION; AMINO ACID SEQUENCE; ANIMAL; ANTIBODY SPECIFICITY; CHEMISTRY; HISTOLOGY; IMMUNOLOGY; KIDNEY; METABOLISM; MOLECULAR GENETICS; RABBIT; TISSUE DISTRIBUTION; VASCULARIZATION; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY SPECIFICITY; BLOTTING, WESTERN; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; RABBITS; RECEPTORS, PROSTAGLANDIN E; TISSUE DISTRIBUTION;

EID: 0032587053     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Breyer MD, Badr KF: Arachidonic acid metabolites and the kidney. In: The Kidney, edited by Brenner MB, Philadelphia, Saunders, 1996, pp 754-788
2. Coleman RA, Smith WL, Narumiya S: International Union of Pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 46: 205-229, 1994
3. Breyer MD, Jacobson HR, Breyer RM: Functional and molecular aspects of renal prostaglandin receptors. J Am Soc Nephrol 7: 8-17, 1996
4. Funk CD, Furci L, FitzGerald GA, Grygorczyk R, Rochette C, Bayne MA, Abramovitz M, Adam M, Metters KM: Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. J Biol Chem 268: 26767-26772, 1993
5. Regan JW, Bailey TJ, Pepperl DJ, Pierce KL, Bogardus AM, Donello JE, Fairbairn CE, Kedzie KM, Woodward DF, Gil DW: Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. Mol Pharmacol 46: 213-220, 1994
6. Bastien L, Sawyer N, Grygorczyk R, Metters KM, Adam M: Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype. J Biol Chem 269: 11873-11877, 1994
7. Kotani M, Tanaka I, Ogawa Y, Usui T, Mori K, Ichikawa A, Narumiya S, Yoshimi T, Nakao K: Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: Multiple second messenger systems and tissue-specific distributions. Mol Pharmacol 48: 869-879, 1995
8. An S, Yang J, So SW, Zeng L, Goetzl EJ: Isoforms of the EPS subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals. Biochemistry 33: 14496-14502, 1994
9. Schmid A, Thierauch KH, Schleuning WD, Dinter H: Splice variants of the human EP3 receptor for prostaglandin E2. Eur J Biochem 228: 23-30, 1995
10. Taniguchi S, Watanabe T, Nakao A, Seki G, Uwatoko S, Kurokawa K: Detection and quantitation of EP3 prostaglandin E2 receptor mRNA along mouse nephron segments by RT-PCR. Am J Physiol 266: C1453-C1458, 1994
11. Breyer MD, Jacobson HR, Davis LS, Breyer RM: In situ hybridization and localization of mRNA for the rabbit prostaglandin EP3 receptor. Kidney Int 44: 1372-1378, 1993
12. Takeuchi K, Abe T, Takahashi N, Abe K: Molecular cloning and intrarenal localization of rat prostaglandin E2 receptor EP3 subtype. Biochem Biophys Res Commun 194: 885-891, 1993
13. Sugimoto Y, Namba T, Shigemoto R, Negishi M, Ichikawa A, Narumiya S: Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney. Am J Physiol 266: F823-F828, 1994
14. Breyer MD, Davis L, Jacobson HR, Breyer RM: Differential localization of prostaglandin E receptor subtypes in human kidney. Am J Physiol 271: F912-F918, 1996
15. Tam JP: Synthetic peptide vaccine design: Synthesis and properties of a high-density multiple antigenic peptide system. Proc Natl Acad Sci USA 85: 5409-5413, 1988
16. Nüsing R, Wernet MP, Ullrich V: Production and characterization of polyclonal and monoclonal antibodies against human thromboxane synthase. Blood 76: 80-85, 1990
17. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970
18. Towbin H, Staehlin T, Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci USA 76: 4350-4354, 1979
19. Kyhse-Andersen J: Electroblotting of multiple gels: A simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J Biochem Biophys Methods 10: 203-209, 1984
20. McKenzie J, McQueen E: Immunofluorescent localization of Tamm-Horsfall mucoprotein in human kidney. J Clin Pathol 22: 334-339, 1969
21. Kotani M, Tanaka I, Ogawa Y, Usui T, Tamura N, Mori K, Narumiya S, Yoshimi T, Nakao K: Structural organization of the human prostaglandin EP(3) receptor subtype gene (PTGER3). Genomics 40: 425-434, 1997
22. Schagger H: Denaturing electrophoretic techniques. In: A Practical Guide to Membrane Protein Purification, edited by von Jagow G, Schagger H, San Diego, Academic Press, 1994, pp 59-79
23. Edwards RM: Effects of prostaglandins on vasoconstrictor action in isolated renal arterioles. Am J Physiol 248: F779-F784, 1985
24. Schor N, Brenner BM: Possible mechanism of prostaglandin-induced renal vasoconstriction in the rat. Hypertension 3: 81-85, 1981
25. Pallone TL: Vasoconstriction of outer medullary vasa recta by angiotensin II is modulated by prostaglandin E2. Am J Physiol 266: F850-F857, 1994
26. Lemley KV, Schmitt SL, Holliger C, Dunn MJ, Robertson CR, Jamison RL: Prostaglandin synthesis inhibitors and vasa recta erythrocyte velocities in the rat. Am J Physiol 247: F562-F567, 1984
27. Silldorff EP, Yang S, Pallone TL: Prostaglandin E2 abrogates endothelin-induced vasoconstriction in renal outer medullary descending vasa recta of the rat. J Clin Invest 95: 2734-2740, 1995
28. Kömhoff M, Gröne HJ, Klein T, Seyberth HW, Nüsing RM: Localization of cyclooxygenase-1 and -2 in adult and fetal human kidney: Implication for renal function. Am J Physiol 272: F460-F468, 1997
29. Schlondorff D, Ardaillou R: Prostaglandins and other arachidonic acid metabolites in the kidney. Kidney Int 29: 108-119, 1986
30. Henrich WL: Role of prostaglandins in renin secretion. Kidney Int 19: 822-830, 1981
31. Freidlander G, Chansel D, Draes J, Bens M, Ardaillou R: PGE2 binding sites and PG-stimulated cyclic AMP accumulation in rat isolated glomeruli and glomerular cultured cells. Mol Cell Endocrinol 30: 201-214, 1983
32. Scharschmidt LA, Lianos E, Dunn MJ: Arachidonate metabolites and the control of glomerular function. Fed Proc 42: 3058-3063, 1983
33. Stokes JB: Effect of prostaglandin E2 on chloride transport across the rabbit thick ascending limb of Henle. J Clin Invest 64: 495-502, 1979
34. Kaji DM, Chase HS, Eng JP, Diaz J: Prostaglandin E(2) inhibits Na-K-2Cl cotransport in medullary thick ascending limb cells. Am J Physiol 271: C354-C361, 1996
35. Hebert RL, Jacobson HR, Breyer MD: Prostaglandin E2 inhibits sodium transport in the rabbit CCD by increasing intracellular calcium. J Clin Invest 87: 1992-1998, 1991
36. Ling BN, Kokko KE, Eaton DC: Inhibition of apical Na+ channels in rabbit cortical collecting tubules by basolateral prostaglandin E2 is modulated by protein kinase C. J Clin Invest 90: 1328-1334, 1992
37. Hebert RL, Jacobson HR, Breyer MD: PGE2 inhibits AVP-induced water flow in cortical collecting ducts by protein kinase C activation. Am J Physiol 259: F318-F325, 1990
38. Sonnenburg WK, Smith WL: Regulation of cyclic AMP metabolism in rabbit cortical collecting tubule cells by prostaglandins. J Biol Chem 263: 6155-6160, 1988
39. Hebert RL, Jacobson HR, Fredin D, Breyer MD: Evidence that separate PGE2 receptors modulate water and sodium transport in rabbit cortical collecting duct. Am J Physiol 265: F643-F650, 1993
40. Nadler SP, Hebert SC, Brenner BM: PGE2, forskolin, and cholera toxin interaction in rabbit cortical collecting tubule. Am J Physiol 250: F127-F135, 1986
41. Hays S, Kokko JP, Jacobson HR: Hormonal regulation of proton secretion in rabbit medullary collecting duct. J Clin Invest 78: 1279-1286, 1986
42. Passmore JC, Hartupee DA, Jackson BA: Urinary and renal papillary solutes during cyclooxygenase inhibition with ibuprofen. J Lab Clin Med 110: 807-812, 1987
43. Jabs K, Zeidel ML, Siva P: Prostaglandin E2 inhibits Na+-K+-ATPase activity in the inner medullary collecting duct. Am J Physiol 257: F424-F430, 1989