Modulation of phospholipase A2 activity generated by molecular evolution

Cellular and Molecular Life Sciences

Volumn 56, Issue 5-6, 1999, Pages 384-397

  Betzel, C ^a   Genov, N ^b   Rajashankar, K R ^b   Singh, T P ^c  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b INSTITUTE OF ORGANIC CHEMISTRY   (Bulgaria)

^c ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Enzyme activity; Enzyme toxicity; Inhibitor; Molecular evolution; Pharmacological sites; Phospholipase A2

Indexed keywords

CALCIUM BINDING PROTEIN; NEUROTOXIN; PHOSPHOLIPASE A2; PROTEIN INHIBITOR; SNAKE VENOM; UNCLASSIFIED DRUG; VIPOXIN; PHOSPHOLIPASE A; VIPER VENOM;

AMINO ACID SEQUENCE; DISULFIDE BOND; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; HUMAN; MOLECULAR EVOLUTION; NONHUMAN; PROTEIN TERTIARY STRUCTURE; REVIEW; SEQUENCE HOMOLOGY; TOXIN STRUCTURE; ANIMAL; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; DRUG ANTAGONISM; ENZYME STABILITY; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SNAKE; X RAY CRYSTALLOGRAPHY;

VIPERA AMMODYTES;

AMINO ACID SEQUENCE; ANIMALS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; EVOLUTION, MOLECULAR; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEUROTOXINS; PHOSPHOLIPASES A; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; VIPER VENOMS; VIPERIDAE;

EID: 0032586407     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000180050440     Document Type: Review

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