Fish odour syndrome

Postgraduate Medical Journal

Volumn 75, Issue 886, 1999, Pages 451-452

  Rehman, H U ^a  

^a HULL ROYAL INFIRMARY   (United Kingdom)

Author keywords

Fish odour syndrome; Trimethylaminuria

Indexed keywords

CARNITINE; CHOLINE; LACTULOSE; METRONIDAZOLE; NEOMYCIN; TRIMETHYLAMINE; TRIMETHYLAMINE OXIDE; METHYLAMINE;

ARTICLE; BREATHING; DIET THERAPY; DIGESTION; FOOD COMPOSITION; HUMAN; INTESTINE FLORA; LIVER METABOLISM; METABOLIC DISORDER; ODOR; OXIDATION; PATIENT COUNSELING; PSYCHOLOGICAL ASPECT; SALIVA; SWEAT; URINARY EXCRETION; VAGINA SECRETION; ENTEROBACTERIACEAE; METABOLISM; OXIDATION REDUCTION REACTION; SYNDROME; URINE;

ENTEROBACTERIACEAE; HUMANS; METABOLIC DISEASES; METHYLAMINES; ODORS; OXIDATION-REDUCTION; SYNDROME;

EID: 0032585715     PISSN: 00325473     EISSN: None     Source Type: Journal    
DOI: 10.1136/pgmj.75.886.451     Document Type: Article

References (24)

1. Humbert JR, Hammond KB, Hathaway WE, Marcoux JG, O'Brien D. Trimethylaminuria: the fish-odour syndrome. Lancet 1970;ii:770-1.
2. Ayesh R, Mitchell SC, Zhang AQ, Smith RL. The fish odour syndrome: biochemical, familial and clinical aspects. BMJ 1993;307:655-7.
3. Willey GR. Trimethylaminea pungent experience. Educat Chem 1985;22:178-81.
4. Hadidi HF, Cholerton S, Atkinson S, Irshaid YM, Rawashdeh NM, Idle JR. The N-oxidation of trimethylamine in a Jordanian population. Br J Clin Pharmacol 1995;39(2):179-81.
5. Mitchell SC, Zhang AQ, Barrett T, Ayesh R, Smith RL. Studies on the discontinuous N-oxidation of trimethylamine among Jordanian, Ecuadorian and New Guinean populations. Pharmacogenetics 1997;7(1):45-50.
6. Zhang AQ, Mitchell SC, Smith RL. Discontinuous distribution of N-oxidation of dietary-derived trimethylamine in a British population. Xenobiotica 1996;26(9):957-61.
7. De La Huerga J, Popper H. Urinary excretion of choline metabolism following administration in normal and patients with hepatobiliary disease. J Clin Invest 1951;30:463-70.
8. Higgins T, Chaykin S, Hammond KB, et al. Trimethylamine N-oxide synthesis: a human variant. Biochem Med 1972;6:392-6.
9. Al-Waiz M, Ayesh R, Mitchell SC, Idle JR, Smith RL. A genetic polymorphism of the N-oxidation of trimethylamine in humans. Clin Pharmacol Ther 1987;42:588-94.
10. Growdon JH, Cohen EL, Wurtman RJ. Huntington's disease: clinical and chemical effects of choline administration. Ann Neurol 1977;1:418-22.
11. Marks R, Dudley F, Wan A. Trimethylamine metabolism in liver disease. Lancet 1978;i: 1106-7.
12. Fernandez MS, Gutierrez C, Vila JJ, et al. Congenital intrahepatic portocaval shunt associated with trimethylaminuria. Pediat Surg Inter 1997; 12:196-7.
13. Simenhoff ML, Ginn HE, Teschan PE. Toxicity of aliphatic amines in uremia. Trans Am Soc Artif Organs 1977;23:560-1.
14. Wills MR, Savory J. Biochemistry of renal failure. Ann Clin Lab Sci 1981;11:292-9.
15. McConnell HW, Mitchell SC, Smith RL, Brewster M. Trimethylaminuria associated with seizures and behavioural disturbance: a case report. Seizure 1997;6:317-21.
16. Brand JM, Galask RP. Trimethylamine: the substance mainly responsible for the fishy odour often associated with bacterial vaginosis. Obstet Gynecol 1986;68:682-5.
17. Pearson AW, Butler EJ, Curtis RF, et al. Effects of rapeseed meal on trimethylamine metabolism in the domestic fowl in relation to egg taint. J Sci Food Agr 1979;30:799-804.
18. Fenwick GR, Butler EJ, Brewster MA. Are brassica vegetables aggravating factors in trimethylaminuria (fish odour syndrome)? Lancet 1983;2:916.
19. Shelley ED, Shelley WB. The fish odour syndrome. JAMA 1984;251:253-5.
20. al-Waiz M, Ayesh R, Mitchell SC, Idle JR, Smith RL. Trimethylaminuria: the detection of carriers using a trimethylamine load test. J Inher Metab Dis 1989;12(1):80-5.
21. Zhang AQ, Mitchell S, Smith R. Fish odour syndrome: verification of carrier detection test. J Inher Metab Dis 1995;18(6):669-74.
22. Rithschild JG, Hansen RC. Fish odor syndrome: Trimethylaminuria with milk as chief dietary factor. Pediatr Dermatol 1985;3:38-9.
23. Pike MG, King GS, Pettit BR, Leonard JV, Atherton DJ. Lactulose in trimethylaminuria, the fish-odour syndrome. Helv Paediatr Acta 1988;43:345-8.
24. Wilcken B. Acid soaps in the fish odour syndrome. BMJ 1993;307:1497.