4-(trans-4-methylcyclohexyl)-4-oxobutyric acid (JTT-608). A new class of antidiabetic agent

Journal of Medicinal Chemistry

Volumn 41, Issue 27, 1998, Pages 5420-5428

  Shinkai, Hisashi ^a   Ozeki, Hidekazu ^a   Motomura, Takahisa ^a   Ohta, Takeshi ^a   Furukawa, Noboru ^a   Uchida, Itsuo ^a  

^a JT Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 METHYLCYCLOHEXYL) 4 OXOBUTYRIC ACID; ANTIDIABETIC AGENT; GLUCOSE; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; INSULIN RELEASE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANIMALS, NEWBORN; BLOOD GLUCOSE; BUTYRIC ACIDS; CYCLOHEXANES; DIABETES MELLITUS, EXPERIMENTAL; DRUG EVALUATION, PRECLINICAL; FASTING; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HYPOGLYCEMIC AGENTS; INSULIN; MALE; PANCREAS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032585591     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9804228     Document Type: Article

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