Antimalarial activities in vitro of homoprotoberberine derivatives. Design of novel antimalarials and structure-activity relationship analysis

Heterocycles

Volumn 49, Issue 1, 1998, Pages 101-104

  Miyata, Junji ^a   Nakashima, Hiromi ^a   Nemoto, Hideo ^a   Kim, Hye Sook ^b   Wataya, Yusuke ^b   Ihara, Masataka ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

9 HYDROXY 2,3,10 TRIMETHOXYHOMOPROTOBERBERINE; HYDROXYL GROUP; PROTOBERBERINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

EID: 0032585409     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/com-98-s46     Document Type: Article

References (9)

1. M. C. Murray and M. E. Perkins, Annual Reports in Medicinal Chemistry, 1996, 31, 141.
2. K. Iwasa, H.-S. Kim, Y. Wataya, and D.-U. Lee, Eur. J. Med. Chem., 1998, 33, 65.
3. J. L. Vennerstrom and D. L. Klayman, J. Med. Chem., 1988, 31, 1084.
4. a) T. Kametani and M. Ihara, J. Chem. Soc., 1967, 530;
5. b) A. Brossi, A. I. Rachlin, S. Teitel, M. Shamma, and M. J. Hillman, Experientia, 1968, 766;
6. A. Brossi and S. Teitel, Helv. Chim, Acta, 1969, 52, 1288;
7. T. Kametani, T. Terui, T. Ogino, and K. Fukumoto, J. Chem. Soc.(C), 1969, 1547;
8. e) T. Kametani, M. Ihara, M. Takemura, and Y. Satoh, Heterocycles, 1980, 14, 817.
9. W. Meise, C. Arth, D. Zlotos, M. Jansen, and C. Feldmann, Liebigs Ann. Chem., 1994, 1135.