Synthesis and cytotoxicity of various structual types of novel cyclopropapyrroloindole(CPI) derivatives

Heterocycles

Volumn 49, Issue 1, 1998, Pages 53-58

  Fukuda, Yasumichi ^a   Furuta, Hirosuke ^a   Kusama, Yoshie ^a   Ebisu, Hiroyuki ^a   Oomori, Yasuo ^a   Terashima, Shiro ^b  

^a KYORIN PHARMACEUTICAL CO LTD   (Japan)

^b SAGAMI CHEMICAL RESEARCH CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADOZELESIN; PYRROLE DERIVATIVE;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CYTOTOXICITY; SYNTHESIS;

EID: 0032585395     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/COM-98-S21     Document Type: Article

References (22)

1. This paper is dedicated to Dr. Bernhard Witkop by celebrating his 80th birthday.
2. B. K. Bhuyan, K. S. Smith, E. G. Adams, G. L. Petzold, and J. P. McGovren, Cancer Res., 1992, 52, 5687 and references therein.
3. L. H. Li, T. F. DeKoning, R. C. Kelly, W. C. Krueger, J. P. McGovren, G. E. Padbury, G. L. Petzold,T. L. Wallace, R. J. Ouding, M. D. Prairie, and I. Gebhard, Cancer Res., 1992, 52, 4904 .
4. A. Asai, S. Nagamura, and H. Saito, J. Am. Chem. Soc., 1994, 116, 4171.
5. a) Y. Fukuda, Y. Oomori, and S. Terashima, Bioorg. Med. Chem. Lett., 1997, 7, 749.
6. b) Y. Fukuda, H. Furuta, F. Shiga, Y. Oomori, Y. Kusama, H. Ebisu and S. Terashima, ibid., 1997, 13, 1683.
7. c) Y. Fukuda, H. Furuta, Y. Kusama, H. Ebisu, Y. Oomori and S. Terashima, in preparation.
8. a) Y. Fukuda, K. Nakatani, and S. Terashima, Bioorg. Med. Chem. Lett., 1992, 2, 755.
9. b) D. L. Boger, W. Yun, S. Terashima, Y. Fukuda, K. Nakatani, P. A. Kitos, and Q. Jin, ibid., 1992, 2, 759.
10. c) Y. Fukuda, K. Nakatani, and S. Terashima, Tetrahedron, 1994, 50, 2809.
11. d) K. Nakatani, Y. Fukuda, and S. Terashima, Pure & Appl. Chem., 1994, 66, 2255.
12. a) Y. Fukuda, K. Nakatani, Y. Ito, and S. Terashima, Tetrahedron, Lett., 1990, 31, 6699.
13. b) Y. Fukuda, Y. Ito, K. Nakatani, and S. Terashima, Tetrahedron, 1994, 50, 2793.
14. R. Krishnamurti, D. R. Bellew, and G. K. S. Prakash, J. Org. Chem., 1991, 56, 984.
15. M. A. Warpehoski, I. Gebhard, R. C. Kelly, W. C. Krueger, L. H. Li, J. P. McGovren, M. D. Prairie, N. Wicnienski, and W. Wierenga, J. Med. Chem., 1988, 31, 590.
16. a) M. Ichimura, T. Ogawa, K. Takahashi, E. Kobayashi, I. Kawamoto, T. Yasuzawa, I. Takahashi, and H. Nakano, J. Antibiot., 1990, 43, 1037.
17. b) T. Yasuzawa, Y. Saitoh, M. Ichimura, I. Takahashi, and H. Sano, ibid., 1991, 44, 445.
18. Y. Fukuda, H. Furuta, F. Shiga, Y. Asahina, and S. Terashima, Heterocycles, 1997, 45, 2303.
19. M. Yogo, C. Ito, and H. Furukawa, Chem. Pharm. Bull., 1991, 39, 328.
20. R. A. Abramovitch, D. H. R. Barton, and J.-P. Finet, Tetrahedron, 1988, 44, 3039 and references therein.
21. U-73,975 (adozelesin) (1) used as the standard compound was synthesized in our laboratories. See, ref. 11.
22. M. Ichimura, T. Ogawa, K. Takahashi, A. Mihara, I. Takahashi, and H. Nakano, Oncology Research, 1993, 5, 165. Also see, ref. 3. and 4.