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Volumn 8, Issue 6, 1998, Pages 758-763

Mutation Analysis of CYP2D6 Locus in the Korean Population: Identification of Rare Poor Metabolizer Alleles at the Nucleotide Level

Author keywords

CYP2D6; Korean; PM

Indexed keywords

CYTOCHROME P450 2D6; DNA; PRIMER DNA;

EID: 0032585361     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (11)

References (25)
  • 1
    • 0025729217 scopus 로고
    • Clinical consequences of polymorphic drug oxidation
    • Alvan, G. (1991) Clinical consequences of polymorphic drug oxidation. Fundam. Clin. Pharm. 5, 209-228.
    • (1991) Fundam. Clin. Pharm. , vol.5 , pp. 209-228
    • Alvan, G.1
  • 2
    • 0025572192 scopus 로고
    • Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations
    • Alvan, G., Bechtel, P., Iselius, L., and Reimy, U. G. (1990) Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations. Eur. J. Clin. Pharmacol. 39, 533-537.
    • (1990) Eur. J. Clin. Pharmacol. , vol.39 , pp. 533-537
    • Alvan, G.1    Bechtel, P.2    Iselius, L.3    Reimy, U.G.4
  • 4
    • 0029053644 scopus 로고
    • Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean. Japanese and Chinese subjects
    • Dahl, M. L., Yue, Q. Y., Roh, H. K., Johansson, I., Sawe, J., Sjoqvist, F., and Bertilsson, L. (1995) Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean. Japanese and Chinese subjects. Pharmacogenetics 5, 159-164.
    • (1995) Pharmacogenetics , vol.5 , pp. 159-164
    • Dahl, M.L.1    Yue, Q.Y.2    Roh, H.K.3    Johansson, I.4    Sawe, J.5    Sjoqvist, F.6    Bertilsson, L.7
  • 6
    • 0028829818 scopus 로고
    • Human CYP2D6 gene polymorphism in Slovene cancer patients and healthy controls
    • Dolzan, V., Rudolf, Z., and Breskvar, K. (1995) Human CYP2D6 gene polymorphism in Slovene cancer patients and healthy controls. Carcinogenesis 16, 2675-2678.
    • (1995) Carcinogenesis , vol.16 , pp. 2675-2678
    • Dolzan, V.1    Rudolf, Z.2    Breskvar, K.3
  • 7
    • 0023854270 scopus 로고
    • Characterization of the common genetic defect in humans deficient in dcbrisoquine metabolism
    • Gonzales, F. J., Skoda, R. C., and Kimura, S. (1988) Characterization of the common genetic defect in humans deficient in dcbrisoquine metabolism. Nature 331, 442-446.
    • (1988) Nature , vol.331 , pp. 442-446
    • Gonzales, F.J.1    Skoda, R.C.2    Kimura, S.3
  • 9
    • 0026811187 scopus 로고
    • Genetic aspects of drug disposition and therapeutics
    • Guttendorf, R. J. and Wedlund, P. J. (1992) Genetic aspects of drug disposition and therapeutics. J. Clin. Pharmacol. 32, 107-117.
    • (1992) J. Clin. Pharmacol. , vol.32 , pp. 107-117
    • Guttendorf, R.J.1    Wedlund, P.J.2
  • 10
    • 0025243460 scopus 로고
    • The human CYP2D locus associated with a common genetic defect in drug oxidation: A G1934fa base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3′ splice recognition site
    • Hanioka, N., Kimura, S., Meyer, U. A., and Gonzalez, F. J. (1990) The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934fA base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3′ splice recognition site. Am. J. Hum. Genet. 47, 994-1001.
    • (1990) Am. J. Hum. Genet. , vol.47 , pp. 994-1001
    • Hanioka, N.1    Kimura, S.2    Meyer, U.A.3    Gonzalez, F.J.4
  • 11
    • 0025830058 scopus 로고
    • Salivary analysis for determination of dextromethorphan metabolic phenotype
    • Hou, Z. Y., Pickle, L. W., Meyer, P.S., and Woosley, R. L. (1991) Salivary analysis for determination of dextromethorphan metabolic phenotype. Clin. Pharmacol. Ther. 49, 410-419.
    • (1991) Clin. Pharmacol. Ther. , vol.49 , pp. 410-419
    • Hou, Z.Y.1    Pickle, L.W.2    Meyer, P.S.3    Woosley, R.L.4
  • 12
    • 0022390883 scopus 로고
    • In vitro inhibition studies of two isozymes of human liver cytochrome P-450: Mephenytoin hydroxylase and Sparteine Monooxygenase
    • Inaba, T., Jurima, M., Mahon, W. A., and Kalow, W. (1985) In vitro inhibition studies of two isozymes of human liver cytochrome P-450: Mephenytoin hydroxylase and Sparteine Monooxygenase. Drug Metabolism and Disposition 4, 443-448.
    • (1985) Drug Metabolism and Disposition , vol.4 , pp. 443-448
    • Inaba, T.1    Jurima, M.2    Mahon, W.A.3    Kalow, W.4
  • 13
    • 0027965620 scopus 로고
    • Genetic analysis of Chinese cytochrome P4502D locus: Chatacterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation
    • Johansson, I., Oscarson, M., Yue, Q. Y., Bertilsson, L., Sjoqvist, F., and Magnus, I. S. (1994) Genetic analysis of Chinese cytochrome P4502D locus: chatacterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation. Mol. Pharmacol. 46, 452-459.
    • (1994) Mol. Pharmacol. , vol.46 , pp. 452-459
    • Johansson, I.1    Oscarson, M.2    Yue, Q.Y.3    Bertilsson, L.4    Sjoqvist, F.5    Magnus, I.S.6
  • 14
    • 0021399224 scopus 로고
    • Sparteine oxidation by the human liver: Absence of inhibition
    • Jurima, M., Inaba, T., and Kalow, W. (1983) sparteine oxidation by the human liver: Absence of inhibition, Clin. Pharmacol. Ther. 35, 426-428.
    • (1983) Clin. Pharmacol. Ther. , vol.35 , pp. 426-428
    • Jurima, M.1    Inaba, T.2    Kalow, W.3
  • 15
    • 0024796958 scopus 로고
    • The human debrisoquin 4-hydroxylase (CYP2D) locus: Sequence and isolation of the polymorphic CYP2D6 gene, a related gene, and a pseudogene
    • Kimura, S., Umeno, M., Skoda, R. C., Meyer, U. A., and Gonzalez, F. J. (1989) The human debrisoquin 4-hydroxylase (CYP2D) locus: sequence and isolation of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. Am. J. Hum. Genet. 45, 889-904.
    • (1989) Am. J. Hum. Genet. , vol.45 , pp. 889-904
    • Kimura, S.1    Umeno, M.2    Skoda, R.C.3    Meyer, U.A.4    Gonzalez, F.J.5
  • 17
    • 0022178173 scopus 로고
    • Interethnic differences in genetic polymorphism of debrisoquine and mephenytoin hydroxylation between Japanese and Caucasian populations
    • Nakamura, K., Goto, F. Ray, W. A., McAllister, C. B., Jacqz, E., Wilkinson, G. R., and Branch, R. A. (1985) Interethnic differences in genetic polymorphism of debrisoquine and mephenytoin hydroxylation between Japanese and Caucasian populations. Clin. Pharmacol. Ther. 38, 402-408.
    • (1985) Clin. Pharmacol. Ther. , vol.38 , pp. 402-408
    • Nakamura, K.1    Goto, F.2    Ray, W.A.3    McAllister, C.B.4    Jacqz, E.5    Wilkinson, G.R.6    Branch, R.A.7
  • 18
    • 0029963622 scopus 로고    scopus 로고
    • Human Drug-Metabolizing enzyme polymorphisms: Effects on Risk of toxicity and cancer
    • Nebert, D. W., Nckinnon, R. A., and Puga, A. (1996) Human Drug-Metabolizing enzyme polymorphisms: Effects on Risk of toxicity and cancer. DNA Cell Biol. 15, 273-280.
    • (1996) DNA Cell Biol. , vol.15 , pp. 273-280
    • Nebert, D.W.1    Nckinnon, R.A.2    Puga, A.3
  • 19
    • 0029824252 scopus 로고    scopus 로고
    • Debrisoquine and S-mephenytoin hydroxylation phenotypes and genotypes in a Korean population
    • Roh, H. K., Dahl, M. L., Johansson, I., Maguns, I. S., Cha, Y. N., and Bertilsson, L. (1996) Debrisoquine and S-mephenytoin hydroxylation phenotypes and genotypes in a Korean population. Pharmacogenetics 6, 441-447.
    • (1996) Pharmacogenetics , vol.6 , pp. 441-447
    • Roh, H.K.1    Dahl, M.L.2    Johansson, I.3    Maguns, I.S.4    Cha, Y.N.5    Bertilsson, L.6
  • 20
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
    • Sachse, C., Brockmoller, J., Bauer, S., and Roots, I. (1997) Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences. Am. J. Hum. Genes. 60, 284-295.
    • (1997) Am. J. Hum. Genes. , vol.60 , pp. 284-295
    • Sachse, C.1    Brockmoller, J.2    Bauer, S.3    Roots, I.4
  • 21
    • 0025358273 scopus 로고
    • Relationship between mephenytoin oxidation polymorphism and phenytoin, methylphenytoin and phenobarbitone hydroxylation assessed in a phenotyped panel of healthy subjects
    • Schellens, J. H. M., Vanderwart, J. H. F., and Breimer, D. D. (1990) Relationship between mephenytoin oxidation polymorphism and phenytoin, methylphenytoin and phenobarbitone hydroxylation assessed in a phenotyped panel of healthy subjects. Br. J. Clin. Pharmacol. 29, 665-671.
    • (1990) Br. J. Clin. Pharmacol. , vol.29 , pp. 665-671
    • Schellens, J.H.M.1    Vanderwart, J.H.F.2    Breimer, D.D.3
  • 22
    • 0345638787 scopus 로고
    • Two mutant alleles of the human cytochrome P450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs
    • Skoda, R. C., Gonzalez, F. J, Demierre, A., and Meyer, U. A. (1988) Two mutant alleles of the human cytochrome P450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs. Proc. Natl. Acad. Sci. USA 85, 5240-5243.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 5240-5243
    • Skoda, R.C.1    Gonzalez, F.J.2    Demierre, A.3    Meyer, U.A.4
  • 23
    • 0026091975 scopus 로고
    • Metoprolol oxidation polymorphism in a Korean population: Comparison with native Japanese and Chinese populations
    • Sohn, D. R, Shin, S. G., Park, C. W., Kusaka, M., and Ishizaki, T. (1991) Metoprolol oxidation polymorphism in a Korean population: comparison with native Japanese and Chinese populations. Br. J. Clin. Pharmacol. 32, 504-507.
    • (1991) Br. J. Clin. Pharmacol. , vol.32 , pp. 504-507
    • Sohn, D.R.1    Shin, S.G.2    Park, C.W.3    Kusaka, M.4    Ishizaki, T.5
  • 25
    • 0025758447 scopus 로고
    • Metabolism of paracetamol and phenacetin in relation to debrisoquine oxidation phenotype
    • Veronese, M. E. and McLean, S. (1991) Metabolism of paracetamol and phenacetin in relation to debrisoquine oxidation phenotype. Eur. J. Clin. Pharmacol. 40, 547-552.
    • (1991) Eur. J. Clin. Pharmacol. , vol.40 , pp. 547-552
    • Veronese, M.E.1    McLean, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.