Identification of a phosphate regulatory site and a low affinity binding site for glucose 6-phosphate in the N-terminal half of human brain hexokinase

Journal of Biological Chemistry

Volumn 273, Issue 31, 1998, Pages 19548-19553

  Fang, Tsuei Yun ^a,b   Alechina, Olga ^a   Aleshin, Alexander E ^a   Fromm, Herbert J ^a   Honzatko, Richard B ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE 6 PHOSPHATE; HEXOKINASE;

ALLOSTERISM; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; CRYSTAL STRUCTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL;

BINDING SITES; BRAIN; CIRCULAR DICHROISM; ENZYME INHIBITORS; GLUCOSE-6-PHOSPHATE; HEXOKINASE; HUMANS; KINETICS; MODELS, MOLECULAR; MUTATION; PHOSPHATES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY;

FELIS CATUS;

EID: 0032584604     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.31.19548     Document Type: Article

References (28)

1. Katzen, H. M., and Schimke, R. T. (1965) Proc. Natl. Acad. Sci. U. S. A. 54, 1218-1225
2. Katzen, H. M., Sodeman, D. D., and Wiley, C. E. (1970) J. Biol. Chem. 245, 4081-4096
3. Lowry, O. H., and Passonneau, J. V. (1964) J. Biol. Chem. 239, 31-42
4. Rapoport, S. (1968) Essays Biochem. 4, 69-103
5. Wilson, J. E. (1995) Rev. Physiol. Biochem. Pharmacol. 126, 65-198
6. Ureta, T. (ed) (1975) Isozymes III (Markert, C. L., ed) pp. 575-601, Academic Press, New York
7. Ellison, W. R., Lueck, J. D., and Fromm, H. J. (1975) J. Biol. Chem. 250, 1864-1871
8. Fromm, H. J. (ed) (1981) The Regulation of Carbohydrate Formation and Utilization in Mammals (Veneziezle, C. M., ed) pp. 45-68, University Park Press, Baltimore, MD
9. Easterby, J. S., and O'Brien, M. J. (1973) Eur. J. Biochem. 38, 201-211
10. Holroyde, M. J., and Trayer, I. P. (1976) FEBS Lett. 62, 215-219
11. Ureta, T. (1982) Comp. Biochem. Physiol. B Comp. Biochem. 71, 549-555
12. Manning, T. A., and Wilson, J. E, (1984) Biochem. Biophys. Res. Commun. 118, 90-96
13. White, T. K., and Wilson, J. E. (1989) Arch. Biochem. Biophys. 274, 375-393
14. Arora, K. K., Filburn, C. R., and Pedersen, P. L. (1991) J. Biol. Chem. 266, 5359-5362
15. Arora, K. K., Filburn, C. R., and Pedersen, P. L. (1993) J. Biol. Chem. 268, 18259-18266
16. Magnani, M., Bianchi, M., Casabianca, A., Stocchi, V., Daniele, A., Altruda, F., Ferrone, M., and Silengo, L. (1992) Biochem. J. 285, 193-199
17. Zeng, C., and Fromm, H. J. (1995) J. Biol. Chem. 270, 10509-10513
18. Tsai, H. J., and Wilson, J. E. (1995) Arch. Biochem. Biophys. 316, 206-214
19. Aleshin, A. E., Zeng, C., Bartunik, H. D., Fromm, H. J., and Honzatko, R. B. (1998) J. Mol. Biol, in press
20. Aleshin, A. E., Zeng, C., Bourenkov, G. P., Bartunik, H. D., Fromm, H. J., and Honzatko, R. B. (1998) Structure 6, 39-50
21. Liu, F., Dong, Q., Myers, A. M., and Fromm, H. J. (1991) Biochem. Biophys. Res. Commun. 177, 305-311
22. Zeng, C., Aleshin, A. E., Hardie, J. B., Harrison, R. W., and Fromm, H. J. (1996) Biochemistry 35, 13157-13164
23. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
24. Ferrari, R. A., Mandelstam, P., and Crane, R. K. (1959) Arch. Biochem. Biophys. 80, 372-377
25. Chakrabarti, U., and Kenkare, U. W. (1974) J. Biol. Chem. 249, 5984-5988
26. Baijal, M., and Wilson, J. E. (1995) Arch. Biochem. Biophys. 321, 413-420
27. Zeng, C., Aleshin, A. E., Chen, G., Honzatko, R. B., and Fromm, H. J. (1998) J. Biol. Chem. 273, 700-704
28. Kraulis, J. (1991) J. Appl. Crystallogr. 24, 946-950