Production and characterization of monoclonal antibodies to oxidized LDL

Experimental and Molecular Medicine

Volumn 30, Issue 1, 1998, Pages 41-45

  Chung, Hong Keun ^a  

^a Seoul National University   (South Korea)

Author keywords

Atherosclerosis; Monoclonal antibodies; Oxidized LDL; Renal glomerular injury

Indexed keywords

ANTIGEN; COPPER SULFATE; EPITOPE; MALONALDEHYDE; MONOCLONAL ANTIBODY; OXIDIZED LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HUMAN; HYBRIDOMA; IMMUNOBLOTTING; MOUSE; MYELOMA CELL; NONHUMAN; SPLEEN CELL;

ANIMALIA;

EID: 0032584129     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.1998.6     Document Type: Article

References (10)

1. Bjorkham, I., Henriksson-Freyschuss, A., Breuer, O., Diezfalusy, U., Berglund, L and Henriksson, P. (1991) The antioxidant butylated hydroxytoluene protects against atherosclerosis. Arteiosclerosis Thromb. 11: 15-22
2. Brown, M. S. and Goldstein, J. L. (1983) Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu. Rev. Biochem. 52: 223-261
3. Carew, T. E., Schwenke, D. C. and Steinberg, D. (1987) Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage- rich fatty streaks slowing the progression of therosclerosis in the WHHL rabbit. Proc. Natl. Acad. Sci. USA. 84: 7725-7729
4. Carlos, T. M. and Marian, J. M. (1990) Membrane proteins involved in phagocyte adherence to endothelium. Immunol. Rev. 114: 5-28
5. Chin, J. H., Azhar, S. and Huffman B. B. (1992) Inactivation of endothelial derived relaxing factor by oxidized lipoproteins. J. Clin. Invest. 89: 10-18
6. Chung, H. K., Kim, S. S. and Suh, P. G. (1984) Development and evaluation of two site binding radioimmunoassay for human alpha fetoprotein using monoclonal antibodies. Korean J. Biochem. 16: 97-103
7. Fogelman, A. M., Schechter, J. S., Hokom, M., Child, J. S. and Edward, P. A., (1980) Malondialdehyde alteration of low density lipoproteins leads to cholesterol accumulation in human monocyte-macrophage. Proc. Natl. Acad. Sci. USA. 77: 2214-2218
8. Goldstein, J. L, Ho, Y. K., Basu, S. K. and Brown, M. S. (1979) Binding site on macrophages that mediates uptake and degradation of actetylated low density lipoprotein, producing massive cholesterol deposition. Proc. Natl. Acad. Sci. USA. 76: 333-337
9. Goldstein, J. L, Basu, S. K. and Brown, M. S. (1983) Receptor-mediated endocytosis of low-density lipoproteins in cultured cells. Meth. Enzymol. 98: 241-260
10. Harberland, M. E., Fong, D. and Cheng, L (1988) Malondialdehydealtered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits. Science. 241: 215-218