Toxicokinetics of trimethyltin in four inbred strains of mice

Toxicology Letters

Volumn 95, Issue 1, 1998, Pages 41-46

  Ekuta, Jethro E ^a,c   Hikal, Ahmed H ^a,b   Matthews, John C ^a,b  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c MEHARRY MEDICAL COLLEGE   (United States)

Author keywords

AKR J; Balb cByJ; C57B1 6J; Convulsion; DBA 2J; Genetic linkage analysis; Toxicodynamic; Toxicokinetic

Indexed keywords

TRIMETHYLTIN;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ARTICLE; CONVULSION; DEATH; DRUG BLOOD LEVEL; GENETIC LINKAGE; INTRAPERITONEAL DRUG ADMINISTRATION; LETHAL DOSE; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; PARESIS; PRIORITY JOURNAL; TONIC CLONIC SEIZURE; TOXICOKINETICS; TREMOR; WEIGHT REDUCTION;

ANIMALS; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HALF-LIFE; INJECTIONS, INTRAPERITONEAL; MALE; MICE; MICE, INBRED STRAINS; PARESIS; SEIZURES; SPECIES SPECIFICITY; TREMOR; TRIMETHYLTIN COMPOUNDS; WEIGHT LOSS;

EID: 0032584040     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00019-8     Document Type: Article

References (17)

1. Aldridge, W.N., Brown, A.W., Briefly, J.B., Verschoyle, R.D., Street, B.W., 1981. Brain damage due to trimethyltin compounds. Lancet 8248, 692-693.
2. Besser, R., Kramer, G., Thumler, R., Bohl, J., Gutman, L., Hopf, H.C., 1987. Acute trimethyltin limbic-cerebellar syndrome. Neurology 37, 945-950.
3. Brown, A.W., Aldridge, W.N., Street, B.W., Verschoyle, R.D., 1979. The behavioral and neuropathologic sequelae of intoxication by trimethyltin compounds in the rat. Am. J. Pathol. 97, 59-82.
4. Chang, L.W., 1986. Neuropathology of trimethyltin: A proposed pathogenetic mechanism. Fundam. Appl. Toxicol. 6, 217-232.
5. Chang, L.W., Wenger, G.R., McMillan, D.E., Dyer, R.S., 1983. Species and strain comparison of acute neurotoxic effects of trimethyltin in mice. Neurobehav. Toxicol. Teratol. 5, 337-350.
6. Davis, W.M., King, W.T., 1967. Pharmacogenetic factor in the convulsive response of mice to flurothyl. Experientia 23, 214-219.
7. Davis, W.M., Webb, O.L., 1964. Chemoconvulsive thresholds in mice of differing audioconvulsive susceptibilities. Experientia 20, 291-293.
8. Dyer, R.S., Walsh, T.J., Wonderlin, W.F., Bercegeay, M., 1982. The trimethyltin syndrome in rats. Neurobehav. Toxicol. Teratol. 4, 127-133.
9. Ekuta, J.E., Allgood, J.C., O'Neal, J.M., Matthews, J.C., 1998. Detection and analysis of methyltins in extracts from mouse tissues following injection of trimethyltin. Anal. Lett, (submitted).
10. Fuller, J.L., Sjursen, F.H., 1967. Audiogenic seizures in eleven mouse strains. J. Hered. 58, 135-140.
11. Matthews, J.C., Scallet, A.C., 1991. Nutrition, neurotoxicants and age-related neurodegeneration. Neurotoxicology 112, 547-558.
12. Mcmillan, D.E., Wenger, G.R., 1985. Neurobehavioral toxicology of trialkyltins. Pharmacol. Rev. 37, 365-379.
13. Michelmore, R., Paran, I., Kesseli, R.V., 1991. Identification of markers linked to disease resistant genes by bulked segregant analysis: A rapid method to detect markers in specific genomic regions by using segregating populations. Proc. Natl. Acad. Sci. USA 88, 9828-9832.
14. Staats, J., 1981. Inbred and segregating inbred strains. In: Foster, H.L., Small, J.D., Fox, J.G. (Eds.), The Mouse in Biomedical Research, vol. 1. Academic Press, New York, pp. 177-213.
15. Welling, P.G., 1986. Pharmacokinetics: Processes and Mathematics, ACS Monograph, vol. 185, Am. Chem. Soc., Washington D.C.
16. Wenger, G.R., McMillan, D.E., Chang, L.W., 1984a. Behavioral effects of trimethyltin in two strains of mice. I. Spontaneous motor activity. Toxicol. Appl. Pharmacol. 73, 78-88.
17. Wenger, G.R., McMillan, D.E., Chang, L.W., 1984b. Behavioral effects of trimethyltin in two strains of mice. II. Multiple fixed ratio, fixed interval. Toxicol. Appl. Pharmacol. 73, 89-96.